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The map label for this gene is pyrD [H]

Identifier: 160903178

GI number: 160903178

Start: 1908398

End: 1909489

Strand: Direct

Name: pyrD [H]

Synonym: Pmob_1743

Alternate gene names: 160903178

Gene position: 1908398-1909489 (Clockwise)

Preceding gene: 160903177

Following gene: 160903179

Centisome position: 87.96

GC content: 38.64

Gene sequence:

>1092_bases
ATGGCTGATATATCTGTTGATTTACTGGGAATGTTGTTAAAAACACCTGTAATGCCTGCGGCTGGACCACCTATTAAAGA
TGGAGAGAGTGCTCACAAAGCCAAAGAAGGAGGAGCTGGTGCGATCGTTACCAAAACGGTTTCCGCCAGAGCAGCAAAAG
TTCCAAAACCAAACATGGCTCAAGTAAAAGGAGGGTTTATCAATACCGAACTTTGGTCTGAGTTATCCTTAGAACAATGG
ATTGAAAAAGAATATCCTCAGGTAGTTGAAACAGGGTTGCCGGTGATAATAGGCGTTGGGTATACCTCTGAAGACATAAA
AGAAGTAATACCAAAAGTAGAACGGTTCGCTGATGCTTTTGAACTGTCTACACATTACCTTGGTAATGATCCAACCCCCA
TGATTAATAGTATAAGAGCAGCGAAAGAAACTACAGATCTTCCCGTTATGGTAAAACTTAGTCCACAAGTAGATATTCCA
AAGTTCGCTAAAGAGGCTGAAAACGCCGGTGCAGATGGTTTAGTCTTAATAAACTCTTTCGGTCCTACCTTAGATATTGA
TTTAGAAAGCGGTAAGCCTTTATTAGGAAGTGAGAATGGTTTTGGATGGTTATCAGGTCAAGCAATATTCCCTTTAGCTT
TGAGATCCGTTTTTGAAGCTGTAAGATCGGTTAATATTCCAGTAGTTGGAGTAGGTGGGATCAATACGGGTAAAGAAGCC
ATAAAGATGATAATGGCAGGAGCCCAAGCTGTACAAGTTTGTACCGCCGCTATTTTGAATGGACCTCAAATATATAAAAA
GATTACCAATGAAATTGAAAAGTATTTGGACGACCATGATTTTAAGTCTTTAGAGGAAATTAGGGGTATTGCTCAAAAAA
ATATTGTTAATGAGGCAAATTATAATTTGATATTTCCAGCCGTAAACGATGAAAAATGTACAGAATGTGCGCTATGTGTC
AAAAGCTGTGTTTACGATGCGATCCATCTCATAAAAGAACTTCACAGTGTAAGAATAGATACAAACAAATGCGCTGGTTG
TGGATTATGTGTGACAAGATGTAATTTCAATGCTCTGTCCTTATCTTTATAA

Upstream 100 bases:

>100_bases
GATGTTCAAATATTTAGAGTCCTCCCAGATAACCGTGAAGAAGTTTACAAAAAGGTGCTAAGCCAGATAAAACTAATACT
TTCAATAAAGGAGTGAATTT

Downstream 100 bases:

>100_bases
AGGGGGAAAATACTATTGTCAAACAAAGATCTTTTACCAATAGCTTTAGGAAAGGAAAAAGCGGATCTAGTATTCAAAAA
CGGGAAAATAATTGATGTTT

Product: dihydroorotate dehydrogenase family protein

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAKVPKPNMAQVKGGFINTELWSELSLEQW
IEKEYPQVVETGLPVIIGVGYTSEDIKEVIPKVERFADAFELSTHYLGNDPTPMINSIRAAKETTDLPVMVKLSPQVDIP
KFAKEAENAGADGLVLINSFGPTLDIDLESGKPLLGSENGFGWLSGQAIFPLALRSVFEAVRSVNIPVVGVGGINTGKEA
IKMIMAGAQAVQVCTAAILNGPQIYKKITNEIEKYLDDHDFKSLEEIRGIAQKNIVNEANYNLIFPAVNDEKCTECALCV
KSCVYDAIHLIKELHSVRIDTNKCAGCGLCVTRCNFNALSLSL

Sequences:

>Translated_363_residues
MADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAKVPKPNMAQVKGGFINTELWSELSLEQW
IEKEYPQVVETGLPVIIGVGYTSEDIKEVIPKVERFADAFELSTHYLGNDPTPMINSIRAAKETTDLPVMVKLSPQVDIP
KFAKEAENAGADGLVLINSFGPTLDIDLESGKPLLGSENGFGWLSGQAIFPLALRSVFEAVRSVNIPVVGVGGINTGKEA
IKMIMAGAQAVQVCTAAILNGPQIYKKITNEIEKYLDDHDFKSLEEIRGIAQKNIVNEANYNLIFPAVNDEKCTECALCV
KSCVYDAIHLIKELHSVRIDTNKCAGCGLCVTRCNFNALSLSL
>Mature_362_residues
ADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAKVPKPNMAQVKGGFINTELWSELSLEQWI
EKEYPQVVETGLPVIIGVGYTSEDIKEVIPKVERFADAFELSTHYLGNDPTPMINSIRAAKETTDLPVMVKLSPQVDIPK
FAKEAENAGADGLVLINSFGPTLDIDLESGKPLLGSENGFGWLSGQAIFPLALRSVFEAVRSVNIPVVGVGGINTGKEAI
KMIMAGAQAVQVCTAAILNGPQIYKKITNEIEKYLDDHDFKSLEEIRGIAQKNIVNEANYNLIFPAVNDEKCTECALCVK
SCVYDAIHLIKELHSVRIDTNKCAGCGLCVTRCNFNALSLSL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=293, Percent_Identity=27.3037542662116, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI87082059, Length=398, Percent_Identity=28.1407035175879, Blast_Score=141, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71984108, Length=469, Percent_Identity=23.8805970149254, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322633, Length=311, Percent_Identity=24.7588424437299, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640763, Length=290, Percent_Identity=29.6551724137931, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18858217, Length=290, Percent_Identity=29.6551724137931, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 39010; Mature: 38879

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00028 ZINC_FINGER_C2H2_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAKVPKPNMA
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEHHHHHHHCCCCCCHH
QVKGGFINTELWSELSLEQWIEKEYPQVVETGLPVIIGVGYTSEDIKEVIPKVERFADAF
HHCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
ELSTHYLGNDPTPMINSIRAAKETTDLPVMVKLSPQVDIPKFAKEAENAGADGLVLINSF
HHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEECC
GPTLDIDLESGKPLLGSENGFGWLSGQAIFPLALRSVFEAVRSVNIPVVGVGGINTGKEA
CCEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHH
IKMIMAGAQAVQVCTAAILNGPQIYKKITNEIEKYLDDHDFKSLEEIRGIAQKNIVNEAN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
YNLIFPAVNDEKCTECALCVKSCVYDAIHLIKELHSVRIDTNKCAGCGLCVTRCNFNALS
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEE
LSL
ECC
>Mature Secondary Structure 
ADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAKVPKPNMA
CCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEHHHHHHHCCCCCCHH
QVKGGFINTELWSELSLEQWIEKEYPQVVETGLPVIIGVGYTSEDIKEVIPKVERFADAF
HHCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
ELSTHYLGNDPTPMINSIRAAKETTDLPVMVKLSPQVDIPKFAKEAENAGADGLVLINSF
HHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEECC
GPTLDIDLESGKPLLGSENGFGWLSGQAIFPLALRSVFEAVRSVNIPVVGVGGINTGKEA
CCEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHH
IKMIMAGAQAVQVCTAAILNGPQIYKKITNEIEKYLDDHDFKSLEEIRGIAQKNIVNEAN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
YNLIFPAVNDEKCTECALCVKSCVYDAIHLIKELHSVRIDTNKCAGCGLCVTRCNFNALS
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEE
LSL
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]