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The map label for this gene is argH

Identifier: 160903136

GI number: 160903136

Start: 1864152

End: 1865477

Strand: Direct

Name: argH

Synonym: Pmob_1701

Alternate gene names: 160903136

Gene position: 1864152-1865477 (Clockwise)

Preceding gene: 160903135

Following gene: 160903137

Centisome position: 85.92

GC content: 34.01

Gene sequence:

>1326_bases
ATGAAATTATGGGGAGGTCGGTTTAAAGAAAAAATTGCAGAAGACATGGAAATATTTAATTCGTCAATAAATGTTGATAT
CAGATTATTGCCCTACGATATAGAAGCGTCATTAGCCCATGCGGAAGGGTTGAAAAAGGCAAAAATTATTTCTGAAGAAG
AGTTTGAACAAATTGAAAGGGCGTTAAGAGAAATAAAAGAAGAAAAATTTGAAGAGATTCCAAAGGTAGAAGATGTGCAC
ACATTGGTAGAGCAAATGTTGGTTGAAAAGATAGGGGATGTGGGCAAAAAGATTCATACAGCAAGAAGTAGGAACGATCA
AATAGCAACAGATGAAAGGATGTACTTACGAAATGAAATATTCAAAATTATAGATTTATTAGAACAATTGAATGTCGTTT
TAGTGGAACTTTCAAAAAAATACAAAAACAAAATTATGCCCGGTTACACACATATGCAAAGAGCTCAACCTATCACATTT
TCTCATCATTTGTTGGCATACGTAGAGATGTTTAAAAGGGATATAGATCGGTTGAAAGATTCTTTGAAAAGAGTGAATGT
TTCGGTTTTAGGTTCAGGAGCATTAGCTGGGACATCGTACGATATAGATAGAACATATGTAGCTTCGTTGTTGGGCTTTA
ATGAGGTTTCACTAAACAGTATTGACGGAGTAAGCGATAGGGATTTCATCGTTGAATTTTTATCAATAGCTTCTTTGATA
ATGATGCATTTGAGTAGATTTTCTGAGGAGATAGTACTTTGGTCTAGCCAAGAGTTCAATTTTGTTGAACTGAGCGATGA
ATATTCGACTGGAAGTAGTATAATGCCACAAAAGAAAAATCCAGACTCTGCTGAATTAATCAGGGGTAAAACGGGTAGGG
TATATGGAAATTTGCTTAGCCTTTTAACAACTATGAAAGGTTTACCCCTTGCGTATAACAAAGATATGCAAGAAGATAAA
GAACCACTGTTTGATACAGTTGATACATTAAAAGTTTGTTTAAAGGTATTTATAGGTATGTTGAAAACGATGAGTGTGAA
CGAAGAAAAAATGAAACAGGCAGTAAAATTTGGTTATCTCAATGCAACGGATTTGGCAGATTATTTGGTCAAAAAAGGGA
TCCCTTTTAGAAACGCTCACGATATAGTTGGAAAATTAGTTGCGTACGCTATAACAAAAAAAGTTCCAATAGAAGAGTTG
AATATTTCAGAATTTAAAAATTTTTGTCAGTCGATAGATGAGGATGTATATGAAGTTTTAAACATAAAAAATATTCTAAA
AAGCCGTAAAACAATTGGGGCAGCCAGATGGGAGGAAGATGTATGA

Upstream 100 bases:

>100_bases
TTATAAACTTGTTTGGACTACCTTTGAAGATGAGAGCTTATCAGATGAAGCATTTTGTTGAAAATCAAAAATACGACAAA
ACGACTGTAGGAGGAGAACA

Downstream 100 bases:

>100_bases
ATGTAGGTATACTTGGTGCAACAGGATACACAGGTATTGAATTAATCAGAATTCTTTCTAAACACCCAAATGCTAAAATA
ACTTATCTGTCATCAAAACA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKLWGGRFKEKIAEDMEIFNSSINVDIRLLPYDIEASLAHAEGLKKAKIISEEEFEQIERALREIKEEKFEEIPKVEDVH
TLVEQMLVEKIGDVGKKIHTARSRNDQIATDERMYLRNEIFKIIDLLEQLNVVLVELSKKYKNKIMPGYTHMQRAQPITF
SHHLLAYVEMFKRDIDRLKDSLKRVNVSVLGSGALAGTSYDIDRTYVASLLGFNEVSLNSIDGVSDRDFIVEFLSIASLI
MMHLSRFSEEIVLWSSQEFNFVELSDEYSTGSSIMPQKKNPDSAELIRGKTGRVYGNLLSLLTTMKGLPLAYNKDMQEDK
EPLFDTVDTLKVCLKVFIGMLKTMSVNEEKMKQAVKFGYLNATDLADYLVKKGIPFRNAHDIVGKLVAYAITKKVPIEEL
NISEFKNFCQSIDEDVYEVLNIKNILKSRKTIGAARWEEDV

Sequences:

>Translated_441_residues
MKLWGGRFKEKIAEDMEIFNSSINVDIRLLPYDIEASLAHAEGLKKAKIISEEEFEQIERALREIKEEKFEEIPKVEDVH
TLVEQMLVEKIGDVGKKIHTARSRNDQIATDERMYLRNEIFKIIDLLEQLNVVLVELSKKYKNKIMPGYTHMQRAQPITF
SHHLLAYVEMFKRDIDRLKDSLKRVNVSVLGSGALAGTSYDIDRTYVASLLGFNEVSLNSIDGVSDRDFIVEFLSIASLI
MMHLSRFSEEIVLWSSQEFNFVELSDEYSTGSSIMPQKKNPDSAELIRGKTGRVYGNLLSLLTTMKGLPLAYNKDMQEDK
EPLFDTVDTLKVCLKVFIGMLKTMSVNEEKMKQAVKFGYLNATDLADYLVKKGIPFRNAHDIVGKLVAYAITKKVPIEEL
NISEFKNFCQSIDEDVYEVLNIKNILKSRKTIGAARWEEDV
>Mature_441_residues
MKLWGGRFKEKIAEDMEIFNSSINVDIRLLPYDIEASLAHAEGLKKAKIISEEEFEQIERALREIKEEKFEEIPKVEDVH
TLVEQMLVEKIGDVGKKIHTARSRNDQIATDERMYLRNEIFKIIDLLEQLNVVLVELSKKYKNKIMPGYTHMQRAQPITF
SHHLLAYVEMFKRDIDRLKDSLKRVNVSVLGSGALAGTSYDIDRTYVASLLGFNEVSLNSIDGVSDRDFIVEFLSIASLI
MMHLSRFSEEIVLWSSQEFNFVELSDEYSTGSSIMPQKKNPDSAELIRGKTGRVYGNLLSLLTTMKGLPLAYNKDMQEDK
EPLFDTVDTLKVCLKVFIGMLKTMSVNEEKMKQAVKFGYLNATDLADYLVKKGIPFRNAHDIVGKLVAYAITKKVPIEEL
NISEFKNFCQSIDEDVYEVLNIKNILKSRKTIGAARWEEDV

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=437, Percent_Identity=44.8512585812357, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303542, Length=437, Percent_Identity=44.8512585812357, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303549, Length=437, Percent_Identity=42.5629290617849, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI68303547, Length=437, Percent_Identity=42.1052631578947, Blast_Score=352, Evalue=5e-97,
Organism=Escherichia coli, GI1790398, Length=439, Percent_Identity=48.9749430523918, Blast_Score=451, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17553882, Length=302, Percent_Identity=25.4966887417219, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32565146, Length=212, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=441, Percent_Identity=44.8979591836735, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI221473854, Length=437, Percent_Identity=41.4187643020595, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI78706858, Length=437, Percent_Identity=41.4187643020595, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_PETMO (A9BIA3)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568717.1
- ProteinModelPortal:   A9BIA3
- SMR:   A9BIA3
- GeneID:   5757416
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1701
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   PMOB403833:PMOB_1701-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50503; Mature: 50503

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFKEKIAEDMEIFNSSINVDIRLLPYDIEASLAHAEGLKKAKIISEEEFEQIER
CCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCHHHHHHCCHHHHHHHHH
ALREIKEEKFEEIPKVEDVHTLVEQMLVEKIGDVGKKIHTARSRNDQIATDERMYLRNEI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FKIIDLLEQLNVVLVELSKKYKNKIMPGYTHMQRAQPITFSHHLLAYVEMFKRDIDRLKD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SLKRVNVSVLGSGALAGTSYDIDRTYVASLLGFNEVSLNSIDGVSDRDFIVEFLSIASLI
HHHHHHHHEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MMHLSRFSEEIVLWSSQEFNFVELSDEYSTGSSIMPQKKNPDSAELIRGKTGRVYGNLLS
HHHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHH
LLTTMKGLPLAYNKDMQEDKEPLFDTVDTLKVCLKVFIGMLKTMSVNEEKMKQAVKFGYL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
NATDLADYLVKKGIPFRNAHDIVGKLVAYAITKKVPIEELNISEFKNFCQSIDEDVYEVL
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHH
NIKNILKSRKTIGAARWEEDV
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLWGGRFKEKIAEDMEIFNSSINVDIRLLPYDIEASLAHAEGLKKAKIISEEEFEQIER
CCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCHHHHHHCCHHHHHHHHH
ALREIKEEKFEEIPKVEDVHTLVEQMLVEKIGDVGKKIHTARSRNDQIATDERMYLRNEI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FKIIDLLEQLNVVLVELSKKYKNKIMPGYTHMQRAQPITFSHHLLAYVEMFKRDIDRLKD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SLKRVNVSVLGSGALAGTSYDIDRTYVASLLGFNEVSLNSIDGVSDRDFIVEFLSIASLI
HHHHHHHHEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MMHLSRFSEEIVLWSSQEFNFVELSDEYSTGSSIMPQKKNPDSAELIRGKTGRVYGNLLS
HHHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHH
LLTTMKGLPLAYNKDMQEDKEPLFDTVDTLKVCLKVFIGMLKTMSVNEEKMKQAVKFGYL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
NATDLADYLVKKGIPFRNAHDIVGKLVAYAITKKVPIEELNISEFKNFCQSIDEDVYEVL
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHH
NIKNILKSRKTIGAARWEEDV
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA