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The map label for this gene is gyaR [H]

Identifier: 160902965

GI number: 160902965

Start: 1646640

End: 1647602

Strand: Direct

Name: gyaR [H]

Synonym: Pmob_1522

Alternate gene names: 160902965

Gene position: 1646640-1647602 (Clockwise)

Preceding gene: 160902964

Following gene: 160902966

Centisome position: 75.9

GC content: 38.11

Gene sequence:

>963_bases
ATGAAAAAAGTTTCAATAACCTACAAAATCCCTGAAGCAGGTATAGATTTGCTAAAAGGTAAGTACGATATTTGGATCAA
TCCAAAGGATAAGCTACTCACCAAAGAAGAATTAAAAGAAATAGCGAAAGAATCTGATGCATTAATTACGATGTTGGCAG
ATCCGATTGATAGTGAAGTGTTAGAAGCAGGAAAGGATAGGTTGAAAATCGTTGCAAACTACGCTGTTGGATACAACAAC
ATCGATATCCAAAAGGCAAAAGAGTTAGGGATATATGTAACTAATACCCCTGATGTATTAACCGAAACAACCGCTGATTT
AGCCTGGGCGTTGATGTTGGTTGTTGCCAGACGAATCGTCGAATCTGATGCCTTTACAAGAGAAGGTAAATTTGATGGCT
GGAAGCCTGAATTGTTTCTGGGAACCGATGTGTACGGTAAAACCTTGGGTATCATAGGATTTGGAAGTATTGGTCAAGCA
GTTGCCCGAAGGGCAATAGGGTTCAATATGAAGGTTTATTACTATCAGAGACATCGTCTCTCCAGTGAAAAAGAAAAGGC
CTTGAATGCCACTTATTTAAACTTGGATGAGCTTTTGAAGGTTTCTGATTATGTAAGCTTACATGTGCCTTTGACTGACG
AGACTTATCATATGTTGGATCGAGAAAAACTATCGCTATTGAAGAAATCTGCCTTTGTTATTAACACAGCAAGAGGTCCA
GTGATAGATGAAGAAGCGTTATACGAAAAACTAAAAAGTAAAGAGATTTCAGGAGCTGCTTTAGATGTGTATGAGAATGA
ACCTCAATTAACACCAGATTTAAAAGATTTGGATAACGTAGTACTAACACCACATATTGGTTCTGCTTCACACGAAACAA
GAAGCCGAATGGCTCAGATGGTAGCAAAAGATATAATACAAGCTTTGGATGGAGAAACACCTGAACATTTAATTTGGAGG
TAG

Upstream 100 bases:

>100_bases
ATTCATTTTTTTATAGGTGGGCAGCGGGGCGGAAGGGTGCTAAAAACTTTTATAGTCTAAGGGCATTAAAAATACCCAAT
CCCAATTAGGAGGTCCAAAA

Downstream 100 bases:

>100_bases
AAATTAAATATTGAATAAAGTTTATGAAATATACAAGGATCTTTACGGGTTTTATGGTCCGCAGCATTGGTGGCCCGCAG
ATAATTGGTTTGAAGTAACT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKKVSITYKIPEAGIDLLKGKYDIWINPKDKLLTKEELKEIAKESDALITMLADPIDSEVLEAGKDRLKIVANYAVGYNN
IDIQKAKELGIYVTNTPDVLTETTADLAWALMLVVARRIVESDAFTREGKFDGWKPELFLGTDVYGKTLGIIGFGSIGQA
VARRAIGFNMKVYYYQRHRLSSEKEKALNATYLNLDELLKVSDYVSLHVPLTDETYHMLDREKLSLLKKSAFVINTARGP
VIDEEALYEKLKSKEISGAALDVYENEPQLTPDLKDLDNVVLTPHIGSASHETRSRMAQMVAKDIIQALDGETPEHLIWR

Sequences:

>Translated_320_residues
MKKVSITYKIPEAGIDLLKGKYDIWINPKDKLLTKEELKEIAKESDALITMLADPIDSEVLEAGKDRLKIVANYAVGYNN
IDIQKAKELGIYVTNTPDVLTETTADLAWALMLVVARRIVESDAFTREGKFDGWKPELFLGTDVYGKTLGIIGFGSIGQA
VARRAIGFNMKVYYYQRHRLSSEKEKALNATYLNLDELLKVSDYVSLHVPLTDETYHMLDREKLSLLKKSAFVINTARGP
VIDEEALYEKLKSKEISGAALDVYENEPQLTPDLKDLDNVVLTPHIGSASHETRSRMAQMVAKDIIQALDGETPEHLIWR
>Mature_320_residues
MKKVSITYKIPEAGIDLLKGKYDIWINPKDKLLTKEELKEIAKESDALITMLADPIDSEVLEAGKDRLKIVANYAVGYNN
IDIQKAKELGIYVTNTPDVLTETTADLAWALMLVVARRIVESDAFTREGKFDGWKPELFLGTDVYGKTLGIIGFGSIGQA
VARRAIGFNMKVYYYQRHRLSSEKEKALNATYLNLDELLKVSDYVSLHVPLTDETYHMLDREKLSLLKKSAFVINTARGP
VIDEEALYEKLKSKEISGAALDVYENEPQLTPDLKDLDNVVLTPHIGSASHETRSRMAQMVAKDIIQALDGETPEHLIWR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=315, Percent_Identity=33.968253968254, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI23308577, Length=281, Percent_Identity=33.8078291814947, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=37.2093023255814, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=37.2093023255814, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=36.5758754863813, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=36.5758754863813, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI145580575, Length=295, Percent_Identity=34.5762711864407, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=39.5638629283489, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1787645, Length=305, Percent_Identity=33.1147540983607, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789279, Length=284, Percent_Identity=33.4507042253521, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=26.615969581749, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=307, Percent_Identity=34.8534201954397, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI25147481, Length=296, Percent_Identity=30.7432432432432, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=257, Percent_Identity=35.7976653696498, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320925, Length=283, Percent_Identity=33.9222614840989, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=283, Percent_Identity=32.1554770318021, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=263, Percent_Identity=27.7566539923954, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=31.9526627218935, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=180, Percent_Identity=27.2222222222222, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=186, Percent_Identity=29.5698924731183, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571528, Length=302, Percent_Identity=38.4105960264901, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI45551003, Length=314, Percent_Identity=35.6687898089172, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=35.6687898089172, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574284, Length=314, Percent_Identity=35.6687898089172, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24585514, Length=314, Percent_Identity=35.6687898089172, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574282, Length=314, Percent_Identity=35.6687898089172, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574286, Length=305, Percent_Identity=35.4098360655738, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI19921140, Length=320, Percent_Identity=34.0625, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=37.4517374517375, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=37.4517374517375, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=37.4517374517375, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=37.4517374517375, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=37.4517374517375, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24585516, Length=316, Percent_Identity=28.1645569620253, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35989; Mature: 35989

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVSITYKIPEAGIDLLKGKYDIWINPKDKLLTKEELKEIAKESDALITMLADPIDSEV
CCEEEEEEECCHHHHHHHCCCEEEEECCHHHCCCHHHHHHHHHHCCCEEEEHHCCCCHHH
LEAGKDRLKIVANYAVGYNNIDIQKAKELGIYVTNTPDVLTETTADLAWALMLVVARRIV
HHCCCHHEEEEEEEEECCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ESDAFTREGKFDGWKPELFLGTDVYGKTLGIIGFGSIGQAVARRAIGFNMKVYYYQRHRL
HHCCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECHHC
SSEKEKALNATYLNLDELLKVSDYVSLHVPLTDETYHMLDREKLSLLKKSAFVINTARGP
CCHHHHHHCCEEECHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHEEEECCCCC
VIDEEALYEKLKSKEISGAALDVYENEPQLTPDLKDLDNVVLTPHIGSASHETRSRMAQM
CCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHCCCEEEECCCCCCCHHHHHHHHHH
VAKDIIQALDGETPEHLIWR
HHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MKKVSITYKIPEAGIDLLKGKYDIWINPKDKLLTKEELKEIAKESDALITMLADPIDSEV
CCEEEEEEECCHHHHHHHCCCEEEEECCHHHCCCHHHHHHHHHHCCCEEEEHHCCCCHHH
LEAGKDRLKIVANYAVGYNNIDIQKAKELGIYVTNTPDVLTETTADLAWALMLVVARRIV
HHCCCHHEEEEEEEEECCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ESDAFTREGKFDGWKPELFLGTDVYGKTLGIIGFGSIGQAVARRAIGFNMKVYYYQRHRL
HHCCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECHHC
SSEKEKALNATYLNLDELLKVSDYVSLHVPLTDETYHMLDREKLSLLKKSAFVINTARGP
CCHHHHHHCCEEECHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHEEEECCCCC
VIDEEALYEKLKSKEISGAALDVYENEPQLTPDLKDLDNVVLTPHIGSASHETRSRMAQM
CCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHCCCEEEECCCCCCCHHHHHHHHHH
VAKDIIQALDGETPEHLIWR
HHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA