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The map label for this gene is uppS [H]

Identifier: 160902093

GI number: 160902093

Start: 669398

End: 670135

Strand: Direct

Name: uppS [H]

Synonym: Pmob_0617

Alternate gene names: 160902093

Gene position: 669398-670135 (Clockwise)

Preceding gene: 160902092

Following gene: 160902094

Centisome position: 30.85

GC content: 33.06

Gene sequence:

>738_bases
GTGGAAAATATAAGTATGAAACTTTCAAAAGTACCTGCCCATGTTGGTATAATTATGGATGGAAACGGAAGATGGGCAAC
TAAAAGTGGCTATGACAGAAACTATGGACATCAAAGGGGTGCTGAAACTGCCCTCAAAGTTATTGAGTGGTCTAAAGAAT
TTGGAATTAATTATCTTACCTTATACACCTTTTCAGAAGAAAATTGGAAGAGACCACAAAATGAAATAGAATTTTTATTT
GATTTACTCATAAGATACTTTGAAGATAACCTTAAACGTATCATAGAAAATGGGGTAAATGTTAGATTTTTGGGAAGGAT
CAATAAACTGCCAGAAAGTCTCATAAAGACTTGTAAAGAAATCGAGGACATAAGTAAAAATAACAAAGATTTCAATTTGA
TCTTCGCCTTGAATTACAGTGGAAGACAAGAGATTGTAGATGCAGTAAATAAAATCTTGAAAGAAAAGAAGACAACAATA
ACAAAAGAAGATATTGACAGCAACCTTTATTTACCAGATGTTCCTTATCCTGATTTAATAATAAGAACAGCAGGTGAAGA
AAGACTAAGTAACTTCTTACTTTGGCAATCTGCTTATTCTGAACTGTATTTTACAGAAACTCTATGGCCTGATTTTTCCT
ATGATGATTACTTCAACGCCCTTTTAGATTATTCTAAAAGAGAGAGACGATTCGGGGGTATAAGCAGTAAGTCTAAAGAT
ATGGAGGAAAACCTTTGA

Upstream 100 bases:

>100_bases
AAAAATTCGAAGAAGAAATCCAAGAGATTTTAAAAGAAAATGAAGATGAAGCAGAAAAAATATTCCAAAGAAAAGAAAAA
GAGATCATGGAGTCATAAAT

Downstream 100 bases:

>100_bases
ATAAAAAAGAACTCTGGACAAGAGTAATATCAGGGGTAATTATTGGACCTATAGTTGTTTTTTCTTATTTAACGTATCCC
ACTCTTTTAGGATTGGTTAC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MENISMKLSKVPAHVGIIMDGNGRWATKSGYDRNYGHQRGAETALKVIEWSKEFGINYLTLYTFSEENWKRPQNEIEFLF
DLLIRYFEDNLKRIIENGVNVRFLGRINKLPESLIKTCKEIEDISKNNKDFNLIFALNYSGRQEIVDAVNKILKEKKTTI
TKEDIDSNLYLPDVPYPDLIIRTAGEERLSNFLLWQSAYSELYFTETLWPDFSYDDYFNALLDYSKRERRFGGISSKSKD
MEENL

Sequences:

>Translated_245_residues
MENISMKLSKVPAHVGIIMDGNGRWATKSGYDRNYGHQRGAETALKVIEWSKEFGINYLTLYTFSEENWKRPQNEIEFLF
DLLIRYFEDNLKRIIENGVNVRFLGRINKLPESLIKTCKEIEDISKNNKDFNLIFALNYSGRQEIVDAVNKILKEKKTTI
TKEDIDSNLYLPDVPYPDLIIRTAGEERLSNFLLWQSAYSELYFTETLWPDFSYDDYFNALLDYSKRERRFGGISSKSKD
MEENL
>Mature_245_residues
MENISMKLSKVPAHVGIIMDGNGRWATKSGYDRNYGHQRGAETALKVIEWSKEFGINYLTLYTFSEENWKRPQNEIEFLF
DLLIRYFEDNLKRIIENGVNVRFLGRINKLPESLIKTCKEIEDISKNNKDFNLIFALNYSGRQEIVDAVNKILKEKKTTI
TKEDIDSNLYLPDVPYPDLIIRTAGEERLSNFLLWQSAYSELYFTETLWPDFSYDDYFNALLDYSKRERRFGGISSKSKD
MEENL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=247, Percent_Identity=34.412955465587, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI45580738, Length=247, Percent_Identity=34.412955465587, Blast_Score=147, Evalue=8e-36,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=39.7435897435897, Blast_Score=188, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=35.1111111111111, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=210, Percent_Identity=36.1904761904762, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=232, Percent_Identity=29.7413793103448, Blast_Score=108, Evalue=9e-25,
Organism=Drosophila melanogaster, GI18857969, Length=237, Percent_Identity=35.0210970464135, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28780; Mature: 28780

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENISMKLSKVPAHVGIIMDGNGRWATKSGYDRNYGHQRGAETALKVIEWSKEFGINYLT
CCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEE
LYTFSEENWKRPQNEIEFLFDLLIRYFEDNLKRIIENGVNVRFLGRINKLPESLIKTCKE
EEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHH
IEDISKNNKDFNLIFALNYSGRQEIVDAVNKILKEKKTTITKEDIDSNLYLPDVPYPDLI
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCE
IRTAGEERLSNFLLWQSAYSELYFTETLWPDFSYDDYFNALLDYSKRERRFGGISSKSKD
EECCCHHHHHHHHHHHHHHHHHEEHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
MEENL
HHHCC
>Mature Secondary Structure
MENISMKLSKVPAHVGIIMDGNGRWATKSGYDRNYGHQRGAETALKVIEWSKEFGINYLT
CCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEE
LYTFSEENWKRPQNEIEFLFDLLIRYFEDNLKRIIENGVNVRFLGRINKLPESLIKTCKE
EEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHH
IEDISKNNKDFNLIFALNYSGRQEIVDAVNKILKEKKTTITKEDIDSNLYLPDVPYPDLI
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCE
IRTAGEERLSNFLLWQSAYSELYFTETLWPDFSYDDYFNALLDYSKRERRFGGISSKSKD
EECCCHHHHHHHHHHHHHHHHHEEHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
MEENL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]