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The map label for this gene is mutL

Identifier: 160902075

GI number: 160902075

Start: 650083

End: 651948

Strand: Direct

Name: mutL

Synonym: Pmob_0599

Alternate gene names: 160902075

Gene position: 650083-651948 (Clockwise)

Preceding gene: 160902058

Following gene: 160902079

Centisome position: 29.96

GC content: 32.15

Gene sequence:

>1866_bases
ATGAGAATAAAAGTGCTTAACCCTGAAGTGGTAATGAAAATAGCGGCTGGAGAAGTTGTATCCGGCCCAAGCTCCGTAGT
TAAAGAATTGGTAGAAAATTCTTTAGATGCCCAAGCAGATAGTATCACCGTTGAAATACTTGATGGTGGCAAATCGTTAA
TAAAAGTCGATGATAACGGAATTGGGATGGAAGAAGAAGAATTAGAATTATCTATACTTCCTCATACCACAAGCAAAATT
TTCTCCATTGAGGATCTTTATAAACTAAAAACATTTGGTTTTAGAGGTGAGGCCCTTTCTTCAATTTCAAGGGTTTCTAG
AATGAAAATGACCTCCAAACCACCCGAAAAAGAAGTTGGAACAATGTTGGAAATATTAGGTGGAAAAATAATAGAAAAAA
AGAGAGTTAATTCATCAAATGGAACGAAAATAGAGATTATGGATCTTTTTTTCAACATTCCTGCACGCCGAAAATTTCTT
AAAAGTGATTCTGCAGAAGGGAGATACGTTACAGAGATTATAGAAAAGTTTGCTTTTACGAACAACATTAACTTAACATA
CATCAGAGACCACAAAGAAATCTACAAATTCTCTTCAGATATGGATCTCATTACAAAATGTTTAAAAATATATCCTGAAT
TAAAAAGAGATGATCTTATAGAAATTGAACACAACGATTCATTGTGCAAAATATCTGGAGTTATTTCGCAACCAAAAGTT
GGAAGAAATAACAGAACCGCCCAACACTTTTTTGTAAACAACAGGTATATTAAGGTAGCTTCACTCTACTCCGTCTTAGA
GACGGGTTACGGCGAGATACTTGAAAAATCAATTCATCCTTATGGAATAATATTCATAGAAATACCACCAGATATGGTAG
ATGTAAATGTCCATCCTCAAAAACTGGAAGTAAAATTCACTGACGAACAGATGGTAGCTTCTTTACTGAAAAAAGTTGTA
AGAGAGTCCCTAAAGAAGAATACTCATTTTACCATGGAATTCATAAATAGTAACGATACAATTGATTTAAATAAAAAAAC
TTCTTCATTTTCTGTTCAAAATTTATACAACAAGAACGAAAGTTCACAAAAAGTTGATTTTTCACAAAACCCTACAAATA
CAGATTATTTTGAAAACACAGACGAATTTTTCAATAACTCTGAAATAGAAGATCTTCAAGAAGAACAAAATCATTTTGAT
AATAGTTATAAACTTTATGAACCATCAAAAACCTTTGATTTTAAAGGTTTTGAATATCAAAAGAATCAGACGTTTACTCC
TGTTGAAAAAATAAATTCTTTAGAAAAATTAAGAATTTTGGGAATAGTTGCTGAAAGATATCTCGTCGTTGAAGGAGAAG
ACAAACTACTTTTAGTAGATTTTCATGCCGCACATGAACGTTATATATACGAAATTTTAAGGGAAAACGTATACGAAAAA
GGCGGACTTACTTCCGATCTTCTACTTACCCCTGTTATAATAGCTTTAGATGAAGTAAGAAAAGGAATAATTTTAGAAAA
TAAAGATCACTTAGAAAAATTGGGTATAAAATTAGAAGAAGATGAAAAAGAAATTATTGTGAAAGGGCTCCCTTCCCTTG
TGAAAATTGATGATGCCGAAAGATTGATATTTGAAATAGCGGATGATCTAAGAATATCAAATTTTGATCAGCAACCAAAC
ATACTTGATAAGAACTTAGCCACTATGGCATGTAGAGCGGCTGTAAAAACTAGAGATAATCCTACCGGTATGGAAACACT
TTTAAACACCATTTTCGAGAAAAAATTACTAACCTGTCCACATGGTAGGCCAATAATGATCCAAATCACCTTTAAAACTT
TAGATAAATACTTTGGAAGAATCTAA

Upstream 100 bases:

>100_bases
ATGTATTTATTATAACAAAAATTCGCTATTTTTTGAGGTTGAGTTTTTTAAAGATGATATAATAATATATGAACTGTTAT
ACTTTGAAGAGGTGTTCTTT

Downstream 100 bases:

>100_bases
AAGGGGTGTAGATTTTACTCACACCCCTTTTTGTTTGTTTATTTATTTATTTAGTTACATTACCACTCTGAAACATTATT
TCCGTTTATCTGGACGACTC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MRIKVLNPEVVMKIAAGEVVSGPSSVVKELVENSLDAQADSITVEILDGGKSLIKVDDNGIGMEEEELELSILPHTTSKI
FSIEDLYKLKTFGFRGEALSSISRVSRMKMTSKPPEKEVGTMLEILGGKIIEKKRVNSSNGTKIEIMDLFFNIPARRKFL
KSDSAEGRYVTEIIEKFAFTNNINLTYIRDHKEIYKFSSDMDLITKCLKIYPELKRDDLIEIEHNDSLCKISGVISQPKV
GRNNRTAQHFFVNNRYIKVASLYSVLETGYGEILEKSIHPYGIIFIEIPPDMVDVNVHPQKLEVKFTDEQMVASLLKKVV
RESLKKNTHFTMEFINSNDTIDLNKKTSSFSVQNLYNKNESSQKVDFSQNPTNTDYFENTDEFFNNSEIEDLQEEQNHFD
NSYKLYEPSKTFDFKGFEYQKNQTFTPVEKINSLEKLRILGIVAERYLVVEGEDKLLLVDFHAAHERYIYEILRENVYEK
GGLTSDLLLTPVIIALDEVRKGIILENKDHLEKLGIKLEEDEKEIIVKGLPSLVKIDDAERLIFEIADDLRISNFDQQPN
ILDKNLATMACRAAVKTRDNPTGMETLLNTIFEKKLLTCPHGRPIMIQITFKTLDKYFGRI

Sequences:

>Translated_621_residues
MRIKVLNPEVVMKIAAGEVVSGPSSVVKELVENSLDAQADSITVEILDGGKSLIKVDDNGIGMEEEELELSILPHTTSKI
FSIEDLYKLKTFGFRGEALSSISRVSRMKMTSKPPEKEVGTMLEILGGKIIEKKRVNSSNGTKIEIMDLFFNIPARRKFL
KSDSAEGRYVTEIIEKFAFTNNINLTYIRDHKEIYKFSSDMDLITKCLKIYPELKRDDLIEIEHNDSLCKISGVISQPKV
GRNNRTAQHFFVNNRYIKVASLYSVLETGYGEILEKSIHPYGIIFIEIPPDMVDVNVHPQKLEVKFTDEQMVASLLKKVV
RESLKKNTHFTMEFINSNDTIDLNKKTSSFSVQNLYNKNESSQKVDFSQNPTNTDYFENTDEFFNNSEIEDLQEEQNHFD
NSYKLYEPSKTFDFKGFEYQKNQTFTPVEKINSLEKLRILGIVAERYLVVEGEDKLLLVDFHAAHERYIYEILRENVYEK
GGLTSDLLLTPVIIALDEVRKGIILENKDHLEKLGIKLEEDEKEIIVKGLPSLVKIDDAERLIFEIADDLRISNFDQQPN
ILDKNLATMACRAAVKTRDNPTGMETLLNTIFEKKLLTCPHGRPIMIQITFKTLDKYFGRI
>Mature_621_residues
MRIKVLNPEVVMKIAAGEVVSGPSSVVKELVENSLDAQADSITVEILDGGKSLIKVDDNGIGMEEEELELSILPHTTSKI
FSIEDLYKLKTFGFRGEALSSISRVSRMKMTSKPPEKEVGTMLEILGGKIIEKKRVNSSNGTKIEIMDLFFNIPARRKFL
KSDSAEGRYVTEIIEKFAFTNNINLTYIRDHKEIYKFSSDMDLITKCLKIYPELKRDDLIEIEHNDSLCKISGVISQPKV
GRNNRTAQHFFVNNRYIKVASLYSVLETGYGEILEKSIHPYGIIFIEIPPDMVDVNVHPQKLEVKFTDEQMVASLLKKVV
RESLKKNTHFTMEFINSNDTIDLNKKTSSFSVQNLYNKNESSQKVDFSQNPTNTDYFENTDEFFNNSEIEDLQEEQNHFD
NSYKLYEPSKTFDFKGFEYQKNQTFTPVEKINSLEKLRILGIVAERYLVVEGEDKLLLVDFHAAHERYIYEILRENVYEK
GGLTSDLLLTPVIIALDEVRKGIILENKDHLEKLGIKLEEDEKEIIVKGLPSLVKIDDAERLIFEIADDLRISNFDQQPN
ILDKNLATMACRAAVKTRDNPTGMETLLNTIFEKKLLTCPHGRPIMIQITFKTLDKYFGRI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=341, Percent_Identity=33.4310850439883, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI4505913, Length=349, Percent_Identity=30.3724928366762, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI310128478, Length=349, Percent_Identity=30.3724928366762, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI4505911, Length=418, Percent_Identity=26.0765550239234, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI189458898, Length=418, Percent_Identity=26.0765550239234, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI310128480, Length=314, Percent_Identity=27.7070063694268, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI189458896, Length=409, Percent_Identity=26.6503667481663, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI263191589, Length=247, Percent_Identity=28.3400809716599, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI91992162, Length=272, Percent_Identity=27.5735294117647, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=272, Percent_Identity=27.5735294117647, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=566, Percent_Identity=29.3286219081272, Blast_Score=214, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=31.6614420062696, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562796, Length=432, Percent_Identity=28.2407407407407, Blast_Score=138, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=325, Percent_Identity=32.6153846153846, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=27.6243093922652, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325093, Length=726, Percent_Identity=24.3801652892562, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=148, Percent_Identity=31.7567567567568, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136968, Length=550, Percent_Identity=27.8181818181818, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=25.9776536312849, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_PETMO (A9BJB9)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001567656.1
- ProteinModelPortal:   A9BJB9
- SMR:   A9BJB9
- GeneID:   5757308
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_0599
- HOGENOM:   HBG520262
- OMA:   DEVINKD
- ProtClustDB:   CLSK2541123
- BioCyc:   PMOB403833:PMOB_0599-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 71151; Mature: 71151

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKVLNPEVVMKIAAGEVVSGPSSVVKELVENSLDAQADSITVEILDGGKSLIKVDDNG
CEEEEECHHHEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEEECCCC
IGMEEEELELSILPHTTSKIFSIEDLYKLKTFGFRGEALSSISRVSRMKMTSKPPEKEVG
CCCCCCCCEEEEECCCCHHHEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
TMLEILGGKIIEKKRVNSSNGTKIEIMDLFFNIPARRKFLKSDSAEGRYVTEIIEKFAFT
HHHHHHCCHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHC
NNINLTYIRDHKEIYKFSSDMDLITKCLKIYPELKRDDLIEIEHNDSLCKISGVISQPKV
CCCEEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCC
GRNNRTAQHFFVNNRYIKVASLYSVLETGYGEILEKSIHPYGIIFIEIPPDMVDVNVHPQ
CCCCCCEEEEEECCCEEEHHHHHHHHHCCHHHHHHHCCCCEEEEEEEECCCEEEECCCCC
KLEVKFTDEQMVASLLKKVVRESLKKNTHFTMEFINSNDTIDLNKKTSSFSVQNLYNKNE
EEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCHHHHHHCCCC
SSQKVDFSQNPTNTDYFENTDEFFNNSEIEDLQEEQNHFDNSYKLYEPSKTFDFKGFEYQ
CCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEC
KNQTFTPVEKINSLEKLRILGIVAERYLVVEGEDKLLLVDFHAAHERYIYEILRENVYEK
CCCCCCHHHHHCHHHHHHHHEEEEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHC
GGLTSDLLLTPVIIALDEVRKGIILENKDHLEKLGIKLEEDEKEIIVKGLPSLVKIDDAE
CCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHCCEEECCCHHHHHHCCCCCEEECCHH
RLIFEIADDLRISNFDQQPNILDKNLATMACRAAVKTRDNPTGMETLLNTIFEKKLLTCP
HHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
HGRPIMIQITFKTLDKYFGRI
CCCEEEEEEEHHHHHHHHCCC
>Mature Secondary Structure
MRIKVLNPEVVMKIAAGEVVSGPSSVVKELVENSLDAQADSITVEILDGGKSLIKVDDNG
CEEEEECHHHEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEEECCCC
IGMEEEELELSILPHTTSKIFSIEDLYKLKTFGFRGEALSSISRVSRMKMTSKPPEKEVG
CCCCCCCCEEEEECCCCHHHEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
TMLEILGGKIIEKKRVNSSNGTKIEIMDLFFNIPARRKFLKSDSAEGRYVTEIIEKFAFT
HHHHHHCCHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHC
NNINLTYIRDHKEIYKFSSDMDLITKCLKIYPELKRDDLIEIEHNDSLCKISGVISQPKV
CCCEEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCC
GRNNRTAQHFFVNNRYIKVASLYSVLETGYGEILEKSIHPYGIIFIEIPPDMVDVNVHPQ
CCCCCCEEEEEECCCEEEHHHHHHHHHCCHHHHHHHCCCCEEEEEEEECCCEEEECCCCC
KLEVKFTDEQMVASLLKKVVRESLKKNTHFTMEFINSNDTIDLNKKTSSFSVQNLYNKNE
EEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCHHHHHHCCCC
SSQKVDFSQNPTNTDYFENTDEFFNNSEIEDLQEEQNHFDNSYKLYEPSKTFDFKGFEYQ
CCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEC
KNQTFTPVEKINSLEKLRILGIVAERYLVVEGEDKLLLVDFHAAHERYIYEILRENVYEK
CCCCCCHHHHHCHHHHHHHHEEEEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHC
GGLTSDLLLTPVIIALDEVRKGIILENKDHLEKLGIKLEEDEKEIIVKGLPSLVKIDDAE
CCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHCCEEECCCHHHHHHCCCCCEEECCHH
RLIFEIADDLRISNFDQQPNILDKNLATMACRAAVKTRDNPTGMETLLNTIFEKKLLTCP
HHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
HGRPIMIQITFKTLDKYFGRI
CCCEEEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA