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The map label for this gene is argH [H]

Identifier: 160877311

GI number: 160877311

Start: 4974450

End: 4975817

Strand: Reverse

Name: argH [H]

Synonym: Sbal195_4209

Alternate gene names: 160877311

Gene position: 4975817-4974450 (Counterclockwise)

Preceding gene: 160877312

Following gene: 160877309

Centisome position: 93.05

GC content: 49.71

Gene sequence:

>1368_bases
ATGGCTTTATGGGGTGGAAGATTTCAGGGCGAAACGAGCGCGCTATTCAAATTATTCAACGATTCGCTACCCGTGGATTA
TCGCCTGTTCGAACAGGATGTGGTCGGCTCTATCGCTTGGGCTGATGCGATTGCTAGCGTGGGTATTATCACAGCCACTG
AATGCAGCGACTTGAAAAAAGCACTCAATGATTTGCTAGTGGAAGTGAATGGCGATCCAGCGATTATTCTCGCGTCGGGC
GCTGAAGATATTCACAGTTTCGTCGAGTCGGCCTTGATTGCCAAAGTGGGCGATCTCGGTAAGAAATTGCACACCGGCCG
TAGCCGTAACGATCAAGTCGCCACCGATTTAAAGCTTTGGTGTCAATCCGAAGGGGCAGCACTACTCGCGCGCCTTCACA
GCTTACATGCTGAATTACTGGCGTTGGCTGAACGTGAATTTGATGCGGTAATGCCAGGTTACACTCACTTGCAGCGCGCC
CAACCTGTGACTTTTGGCCACTGGTGTTTAGCATATGTGGAAATGTATGAGCGGGATATCAGCCGTTTAGCCGATGCGTT
AACCCGCGCTAACACCTGTCCATTAGGTTCAGGCGCCCTTGCGGGCACTGCCTATAAAATGGATCGGCATGCACTGGCTG
CTGCGCTTAATTTTGCCTCGCCGACGCTCAATAGCTTAGACAGTGTGTCAGACAGAGATCACGTGGTAGAACTGTGTTCA
ACGGCATCGATCAGCATGATGCATTTAAGCCGTATGGCCGAAGATTTGATTTTCTTTAACTCGGGCGAAGCCAACTTTAT
CTCTCTGAGTGATGAAGTGACCTCGGGTTCATCCCTGATGCCACAGAAGAAAAATCCTGATGCATTAGAGCTTATCCGTG
GTAAAACGGGTCGGGTTTATGGCAGTTTAGTGGGCATTCTCACCACCATGAAAGCACTGCCTTTGGCGTATAACAAAGAT
ATGCAGGAAGATAAAGAAGGCCTGTTTGACGTAGTTGATAGCTGGGCAATTTGCCTCGATATGGCGGCGTTAGTGTTATC
GGGTCTGAAAGTTAATCGTCCTAATGCGCTGTTAGCTGCGCAGCAAGGTTATGCCAACTCTACTGAGTTAGCTGATTATC
TAGTTTCTAAGGGTATGCCTTTCCGTGAGGCGCACCACGTTGTGGGTGAAGTGGTGGTTGCCGCGATAGCGAAGCAAATT
CCGCTGGAGGAATTCTCCTTGGCCGAGTTAAAAACCTTTGCCGCCATCATTGAAGATGACGTTTATCCTAACCTCACCAT
TGAAGCCTGTTTAGCGAAACGCGATGTGCTTGGTGGGACAGCTCTGCCGCAAATTCAGCAGGCGATCGCGGCTAAAAAAG
CCCGCTAA

Upstream 100 bases:

>100_bases
TAACAGGGCGCCTAGCGCCCTTTTTTGTTTCTAGGTTTTGATCAAGTTTTTTGATTCAGATGAGTCGATTTCAAATCAGC
AGTGAGTAAGGGGAGTTAGC

Downstream 100 bases:

>100_bases
GGCAAGTTGTTCAAATCAACAAGCCAATAAAAAACGCGACGTTAAGTCGCGTTTTTTATTGGGTCATTATCCGTATGGGC
AATGACTTTCTATGAGTCGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MALWGGRFQGETSALFKLFNDSLPVDYRLFEQDVVGSIAWADAIASVGIITATECSDLKKALNDLLVEVNGDPAIILASG
AEDIHSFVESALIAKVGDLGKKLHTGRSRNDQVATDLKLWCQSEGAALLARLHSLHAELLALAEREFDAVMPGYTHLQRA
QPVTFGHWCLAYVEMYERDISRLADALTRANTCPLGSGALAGTAYKMDRHALAAALNFASPTLNSLDSVSDRDHVVELCS
TASISMMHLSRMAEDLIFFNSGEANFISLSDEVTSGSSLMPQKKNPDALELIRGKTGRVYGSLVGILTTMKALPLAYNKD
MQEDKEGLFDVVDSWAICLDMAALVLSGLKVNRPNALLAAQQGYANSTELADYLVSKGMPFREAHHVVGEVVVAAIAKQI
PLEEFSLAELKTFAAIIEDDVYPNLTIEACLAKRDVLGGTALPQIQQAIAAKKAR

Sequences:

>Translated_455_residues
MALWGGRFQGETSALFKLFNDSLPVDYRLFEQDVVGSIAWADAIASVGIITATECSDLKKALNDLLVEVNGDPAIILASG
AEDIHSFVESALIAKVGDLGKKLHTGRSRNDQVATDLKLWCQSEGAALLARLHSLHAELLALAEREFDAVMPGYTHLQRA
QPVTFGHWCLAYVEMYERDISRLADALTRANTCPLGSGALAGTAYKMDRHALAAALNFASPTLNSLDSVSDRDHVVELCS
TASISMMHLSRMAEDLIFFNSGEANFISLSDEVTSGSSLMPQKKNPDALELIRGKTGRVYGSLVGILTTMKALPLAYNKD
MQEDKEGLFDVVDSWAICLDMAALVLSGLKVNRPNALLAAQQGYANSTELADYLVSKGMPFREAHHVVGEVVVAAIAKQI
PLEEFSLAELKTFAAIIEDDVYPNLTIEACLAKRDVLGGTALPQIQQAIAAKKAR
>Mature_454_residues
ALWGGRFQGETSALFKLFNDSLPVDYRLFEQDVVGSIAWADAIASVGIITATECSDLKKALNDLLVEVNGDPAIILASGA
EDIHSFVESALIAKVGDLGKKLHTGRSRNDQVATDLKLWCQSEGAALLARLHSLHAELLALAEREFDAVMPGYTHLQRAQ
PVTFGHWCLAYVEMYERDISRLADALTRANTCPLGSGALAGTAYKMDRHALAAALNFASPTLNSLDSVSDRDHVVELCST
ASISMMHLSRMAEDLIFFNSGEANFISLSDEVTSGSSLMPQKKNPDALELIRGKTGRVYGSLVGILTTMKALPLAYNKDM
QEDKEGLFDVVDSWAICLDMAALVLSGLKVNRPNALLAAQQGYANSTELADYLVSKGMPFREAHHVVGEVVVAAIAKQIP
LEEFSLAELKTFAAIIEDDVYPNLTIEACLAKRDVLGGTALPQIQQAIAAKKAR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=452, Percent_Identity=44.2477876106195, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=452, Percent_Identity=44.2477876106195, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI68303549, Length=452, Percent_Identity=42.2566371681416, Blast_Score=334, Evalue=9e-92,
Organism=Homo sapiens, GI68303547, Length=452, Percent_Identity=41.8141592920354, Blast_Score=328, Evalue=5e-90,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=65.7142857142857, Blast_Score=612, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6321806, Length=444, Percent_Identity=44.1441441441441, Blast_Score=365, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221473854, Length=445, Percent_Identity=42.0224719101124, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI78706858, Length=445, Percent_Identity=42.0224719101124, Blast_Score=335, Evalue=5e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 49154; Mature: 49023

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFQGETSALFKLFNDSLPVDYRLFEQDVVGSIAWADAIASVGIITATECSDLKK
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHH
ALNDLLVEVNGDPAIILASGAEDIHSFVESALIAKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CQSEGAALLARLHSLHAELLALAEREFDAVMPGYTHLQRAQPVTFGHWCLAYVEMYERDI
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
SRLADALTRANTCPLGSGALAGTAYKMDRHALAAALNFASPTLNSLDSVSDRDHVVELCS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHH
TASISMMHLSRMAEDLIFFNSGEANFISLSDEVTSGSSLMPQKKNPDALELIRGKTGRVY
HHHHHHHHHHHHHHHHEEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLVGILTTMKALPLAYNKDMQEDKEGLFDVVDSWAICLDMAALVLSGLKVNRPNALLAA
HHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
QQGYANSTELADYLVSKGMPFREAHHVVGEVVVAAIAKQIPLEEFSLAELKTFAAIIEDD
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
VYPNLTIEACLAKRDVLGGTALPQIQQAIAAKKAR
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALWGGRFQGETSALFKLFNDSLPVDYRLFEQDVVGSIAWADAIASVGIITATECSDLKK
CCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHH
ALNDLLVEVNGDPAIILASGAEDIHSFVESALIAKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CQSEGAALLARLHSLHAELLALAEREFDAVMPGYTHLQRAQPVTFGHWCLAYVEMYERDI
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
SRLADALTRANTCPLGSGALAGTAYKMDRHALAAALNFASPTLNSLDSVSDRDHVVELCS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHH
TASISMMHLSRMAEDLIFFNSGEANFISLSDEVTSGSSLMPQKKNPDALELIRGKTGRVY
HHHHHHHHHHHHHHHHEEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLVGILTTMKALPLAYNKDMQEDKEGLFDVVDSWAICLDMAALVLSGLKVNRPNALLAA
HHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
QQGYANSTELADYLVSKGMPFREAHHVVGEVVVAAIAKQIPLEEFSLAELKTFAAIIEDD
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
VYPNLTIEACLAKRDVLGGTALPQIQQAIAAKKAR
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA