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The map label for this gene is lysA [H]

Identifier: 160877194

GI number: 160877194

Start: 4822794

End: 4824038

Strand: Reverse

Name: lysA [H]

Synonym: Sbal195_4090

Alternate gene names: 160877194

Gene position: 4824038-4822794 (Counterclockwise)

Preceding gene: 160877195

Following gene: 160877193

Centisome position: 90.21

GC content: 50.76

Gene sequence:

>1245_bases
TTGGATCACTTTCTCTACCAACAAAATGCCCTGCACGCCGAAGGCTGCCAGGTTGCCGATTTAGCTCAAACCTATGGCAC
ACCGCTGTATATCTATTCCCGCGCCACGCTAGAGCGCCATTGGCATGCTTTTAATAATGCCGTGGCAGATCATCCACATT
TGATTTGTTACGCGGTTAAAGCCAATGCGAACTTGGCTGTACTGAATGTGCTGGCACGTTTAGGCAGTGGTTTTGATATC
GTGTCGGGCGGTGAGTTAGCAAGAGTGATGGAAGCGGGCGGCGATCCCGCCAAAGTGGTGTTCTCTGGCGTGGGTAAAAC
TGCGGCTGAAATGGAACAGGCACTTAATCTGGGCATTTATTGCTTTAACGTTGAATCGAGCGCTGAGCTTGAGCTGTTAA
ATCTGGTCGCAGGTCGTTTAGGTAAAGTCGCGCCTGTGTCCCTGCGGATTAATCCCGATGTGGATGCGGGAACTCATCCC
TACATTTCGACTGGCCTTAAAGAAAACAAATTCGGTATTGCTATGGATGAGGCTGAAATCGTTTTCGCCCGTGCCCATGC
GTTGCCACATTTAAAAGTGAAAGGTGTCGATTGCCATATCGGCTCACAACTGACTGAAATCAAACCATTCCTCGATGCGA
TGGATCGTATGCTTGCGTTAATCGACCGTTTGGCCGAGCAGGGTATTGTTATTGAGCATTTCGATGTGGGTGGTGGTTTA
GGGGTGACCTATGATGCCGAAACGCCGCCGCATCCTGATGTGTATGCCGCCGCCATATTGGCGCGTTTGGGCGACCGTCA
ACTGAAGCTAATCTTCGAGCCGGGCCGTGCGATTGCCGCCAATGCGGGGATTTTTGTTACTCAAGTGCTGTATCTTAAAG
AAAACAGCGACAAACGTTTTGCGATTGTCGATGGCGCGATGAATGACTTGATTCGTCCCGCACTCTACAGTGCATGGCAA
AATATTATCCCAGTCGTGCCAAGGGACTCAGAGGCCTATGAGTTTGATATTGTTGGCCCAGTGTGCGAAACCGGTGACTT
TTTAGGTAAAAATCGCCAGCTCGCGTTAGCCGCGGGTGATTTACTGGCGGTGCGTTCGAGTGGTGCCTATGGTTTTGCCA
TGGCCTCTAACTACAACACGCGTCCTCGTGCGGCTGAAGTTATGGTGGATGGTGAGCAGGCTTTCTTAGTGCGTGAGCGA
GAAAAATTGTCTCAGCTCTGGCAAGGTGAGCAACTCCTGCCGTAA

Upstream 100 bases:

>100_bases
AATTAGAGCCATCGAAGCACAAAAAACACAACAATAACAATCGCTATAACTACAACGACCATCACTATAGCAGCGATAAA
GCGCAGTAAGGAATCAGACA

Downstream 100 bases:

>100_bases
ACTAGAAAATTATATTGATTCAGGCGCTTGGTTTCATACTTTATGAGCGGCGCCTCGGCTTAAAGGATAAGTATCTTGAT
CCAATTCACTAAGATGCACG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDHFLYQQNALHAEGCQVADLAQTYGTPLYIYSRATLERHWHAFNNAVADHPHLICYAVKANANLAVLNVLARLGSGFDI
VSGGELARVMEAGGDPAKVVFSGVGKTAAEMEQALNLGIYCFNVESSAELELLNLVAGRLGKVAPVSLRINPDVDAGTHP
YISTGLKENKFGIAMDEAEIVFARAHALPHLKVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYDAETPPHPDVYAAAILARLGDRQLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVVPRDSEAYEFDIVGPVCETGDFLGKNRQLALAAGDLLAVRSSGAYGFAMASNYNTRPRAAEVMVDGEQAFLVRER
EKLSQLWQGEQLLP

Sequences:

>Translated_414_residues
MDHFLYQQNALHAEGCQVADLAQTYGTPLYIYSRATLERHWHAFNNAVADHPHLICYAVKANANLAVLNVLARLGSGFDI
VSGGELARVMEAGGDPAKVVFSGVGKTAAEMEQALNLGIYCFNVESSAELELLNLVAGRLGKVAPVSLRINPDVDAGTHP
YISTGLKENKFGIAMDEAEIVFARAHALPHLKVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYDAETPPHPDVYAAAILARLGDRQLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVVPRDSEAYEFDIVGPVCETGDFLGKNRQLALAAGDLLAVRSSGAYGFAMASNYNTRPRAAEVMVDGEQAFLVRER
EKLSQLWQGEQLLP
>Mature_414_residues
MDHFLYQQNALHAEGCQVADLAQTYGTPLYIYSRATLERHWHAFNNAVADHPHLICYAVKANANLAVLNVLARLGSGFDI
VSGGELARVMEAGGDPAKVVFSGVGKTAAEMEQALNLGIYCFNVESSAELELLNLVAGRLGKVAPVSLRINPDVDAGTHP
YISTGLKENKFGIAMDEAEIVFARAHALPHLKVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYDAETPPHPDVYAAAILARLGDRQLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVVPRDSEAYEFDIVGPVCETGDFLGKNRQLALAAGDLLAVRSSGAYGFAMASNYNTRPRAAEVMVDGEQAFLVRER
EKLSQLWQGEQLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=361, Percent_Identity=26.5927977839335, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI22538418, Length=356, Percent_Identity=24.7191011235955, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI21361583, Length=356, Percent_Identity=24.7191011235955, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI16506287, Length=348, Percent_Identity=24.7126436781609, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789203, Length=433, Percent_Identity=29.3302540415704, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17562780, Length=357, Percent_Identity=23.8095238095238, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6322664, Length=389, Percent_Identity=25.4498714652956, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24586474, Length=370, Percent_Identity=25.6756756756757, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44955; Mature: 44955

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFLYQQNALHAEGCQVADLAQTYGTPLYIYSRATLERHWHAFNNAVADHPHLICYAVK
CCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCCEEEEEEEE
ANANLAVLNVLARLGSGFDIVSGGELARVMEAGGDPAKVVFSGVGKTAAEMEQALNLGIY
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCHHHHEECCCHHHHHHHHHHCCCEE
CFNVESSAELELLNLVAGRLGKVAPVSLRINPDVDAGTHPYISTGLKENKFGIAMDEAEI
EEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCEEEECCHHE
VFARAHALPHLKVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
EEEEHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GVTYDAETPPHPDVYAAAILARLGDRQLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEECCCEEEEEEEEEEECCCCEE
AIVDGAMNDLIRPALYSAWQNIIPVVPRDSEAYEFDIVGPVCETGDFLGKNRQLALAAGD
EEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHCCCCCEEEEEECC
LLAVRSSGAYGFAMASNYNTRPRAAEVMVDGEQAFLVREREKLSQLWQGEQLLP
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCHHEEHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDHFLYQQNALHAEGCQVADLAQTYGTPLYIYSRATLERHWHAFNNAVADHPHLICYAVK
CCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCCEEEEEEEE
ANANLAVLNVLARLGSGFDIVSGGELARVMEAGGDPAKVVFSGVGKTAAEMEQALNLGIY
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCHHHHEECCCHHHHHHHHHHCCCEE
CFNVESSAELELLNLVAGRLGKVAPVSLRINPDVDAGTHPYISTGLKENKFGIAMDEAEI
EEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCEEEECCHHE
VFARAHALPHLKVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
EEEEHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GVTYDAETPPHPDVYAAAILARLGDRQLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEECCCEEEEEEEEEEECCCCEE
AIVDGAMNDLIRPALYSAWQNIIPVVPRDSEAYEFDIVGPVCETGDFLGKNRQLALAAGD
EEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHCCCCCEEEEEECC
LLAVRSSGAYGFAMASNYNTRPRAAEVMVDGEQAFLVREREKLSQLWQGEQLLP
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCHHEEHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]