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The map label for this gene is hemE [H]

Identifier: 160877146

GI number: 160877146

Start: 4758400

End: 4759464

Strand: Reverse

Name: hemE [H]

Synonym: Sbal195_4042

Alternate gene names: 160877146

Gene position: 4759464-4758400 (Counterclockwise)

Preceding gene: 160877147

Following gene: 160877145

Centisome position: 89.01

GC content: 47.61

Gene sequence:

>1065_bases
ATGGCAGAATTAAAGAATGATCGTTATTTACGCGCCCTACTAAAAGAGCCAGTCGATGTGACCCCTGTGTGGATGATGCG
TCAAGCTGGCCGTTATCTTCCTGAATATAAAGCTACGCGCGCACAAGCGGGTGACTTTATGTCTTTGTGTAAAAACCACG
AGCTTGCCTGTGAAGTCACGCTGCAACCTCTACGCCGATATGATCTTGATGCGGCGATTCTGTTTTCCGATATTTTAACT
GTGCCTGATGCTATGGGTTTAGGTTTGTATTTTGAGGCGGGTGAAGGCCCACGTTTCGAGCGCCCTACAGACACTATCGA
TGCAATTAAAAAGCTATCAATCCCAGATCCAGAAGATGAGCTTGGCTATGTGATGAAAGCCGTGAGCACTATTCGCCGTG
AGCTTAATGGCGCAGTGCCGTTAATTGGCTTTTCTGGCTCGCCATGGACCTTAGCCACTTATATGGTTGAAGGTGGCTCG
AGCAAAACTTTCGAAAAAATTAAAAAGATGGCTTACGCTGAGCCAATGGCATTACACATGCTGTTAGACAAGCTAGCTGA
TTCAGTGATCTTATACCTGAATGCCCAAGTCGCCAACGGCGCACAATCTTTGATGATTTTTGACTCATGGGGCGGCGCGT
TATCGCACTCAGCTTATCGTGAGTTCTCTTTGCGTTACATGCAGAAGATTATTGATGGTCTGACACGCTTTGCCGATGGA
CGTAAAGTGCCTGTGACGCTGTTCACTAAAGGCGGCGGTTTATGGTTAGAAGCCATGGCAGAAACAGGTTGTGATGCGCT
CGGTTTAGATTGGACGGTAGACATTGCCGATGCTCGTCGCCGTGTAGGCCATAAAGTGGCCCTGCAAGGCAACATGGACC
CTTCAATGTTGTATGCACCTATTCCACGCATCGAAGAAGAAGTGGGCCATATCCTCGCGGGTTATGGTGAAGGTACTGGT
CATGTATTTAACTTAGGCCATGGTATACATCAGCATGTCGATCCAGAGCATGCTGGCGCCTTTATTAAGGCGGTTCACGC
ACAATCAAAGCAATACCATAAGTAA

Upstream 100 bases:

>100_bases
GGGAATAGCTCACATAAATTAGCACATAAAGGTTACATTATTCGCGTAAATGCTAAACTACCGACCCAGCGGATCTCAAT
AAGACTAGGAACCAAGCCCA

Downstream 100 bases:

>100_bases
TTTTTGGATTCGCGAAAACAGGCCCGCTTGCGGGCCTGTTTTATTTCTGACATTTAGAGTTGATAAAATTGAAAACTTCT
CTCGCAGCTATCTTCATGGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAELKNDRYLRALLKEPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYDLDAAILFSDILT
VPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLSIPDPEDELGYVMKAVSTIRRELNGAVPLIGFSGSPWTLATYMVEGGS
SKTFEKIKKMAYAEPMALHMLLDKLADSVILYLNAQVANGAQSLMIFDSWGGALSHSAYREFSLRYMQKIIDGLTRFADG
RKVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVGHILAGYGEGTG
HVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK

Sequences:

>Translated_354_residues
MAELKNDRYLRALLKEPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYDLDAAILFSDILT
VPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLSIPDPEDELGYVMKAVSTIRRELNGAVPLIGFSGSPWTLATYMVEGGS
SKTFEKIKKMAYAEPMALHMLLDKLADSVILYLNAQVANGAQSLMIFDSWGGALSHSAYREFSLRYMQKIIDGLTRFADG
RKVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVGHILAGYGEGTG
HVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK
>Mature_353_residues
AELKNDRYLRALLKEPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYDLDAAILFSDILTV
PDAMGLGLYFEAGEGPRFERPTDTIDAIKKLSIPDPEDELGYVMKAVSTIRRELNGAVPLIGFSGSPWTLATYMVEGGSS
KTFEKIKKMAYAEPMALHMLLDKLADSVILYLNAQVANGAQSLMIFDSWGGALSHSAYREFSLRYMQKIIDGLTRFADGR
KVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVGHILAGYGEGTGH
VFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=357, Percent_Identity=47.8991596638655, Blast_Score=318, Evalue=4e-87,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=80.7909604519774, Blast_Score=593, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=39.031339031339, Blast_Score=258, Evalue=7e-70,
Organism=Drosophila melanogaster, GI19921920, Length=346, Percent_Identity=42.7745664739884, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI221330099, Length=346, Percent_Identity=42.7745664739884, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39216; Mature: 39084

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELKNDRYLRALLKEPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYDLDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLSIPDPEDE
HHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHH
LGYVMKAVSTIRRELNGAVPLIGFSGSPWTLATYMVEGGSSKTFEKIKKMAYAEPMALHM
HHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLADSVILYLNAQVANGAQSLMIFDSWGGALSHSAYREFSLRYMQKIIDGLTRFADG
HHHHHHHHEEEEEECHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RKVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAP
CCCEEEEEECCCCHHHHHHHHCCCCEECCCEEEEHHHHHHHCCCEEEEECCCCCHHEECC
IPRIEEEVGHILAGYGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK
CCHHHHHHHHEEECCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AELKNDRYLRALLKEPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYDLDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLSIPDPEDE
HHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHH
LGYVMKAVSTIRRELNGAVPLIGFSGSPWTLATYMVEGGSSKTFEKIKKMAYAEPMALHM
HHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLADSVILYLNAQVANGAQSLMIFDSWGGALSHSAYREFSLRYMQKIIDGLTRFADG
HHHHHHHHEEEEEECHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RKVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAP
CCCEEEEEECCCCHHHHHHHHCCCCEECCCEEEEHHHHHHHCCCEEEEECCCCCHHEECC
IPRIEEEVGHILAGYGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK
CCHHHHHHHHEEECCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA