Click here to switch to the map view.

The map label for this gene is prs [H]

Identifier: 160876845

GI number: 160876845

Start: 4407578

End: 4408525

Strand: Direct

Name: prs [H]

Synonym: Sbal195_3741

Alternate gene names: 160876845

Gene position: 4407578-4408525 (Clockwise)

Preceding gene: 160876844

Following gene: 160876847

Centisome position: 82.43

GC content: 48.95

Gene sequence:

>948_bases
GTGCCCGACATCAAGCTCTTTGCTGGGAACGCCACCCCCAGTCTCGCTAAAAAGATAGCCGATCGTCTATTTTGCAAACT
CGGAGACGCAGTGGTTGGTCGTTTCAGCGATGGTGAAATCAGTGTCCAAATTAACGAAAATGTACGTGGTGCCGATGTGT
TCATCATCCAATCCACTTGCGCGCCGACAAACGACAACCTGATGGAACTCATCGTGATGGTTGACGCGCTGCGCCGTGCA
TCTGCTGGCCGTATCACAGCCGTTATTCCTTACTTTGGTTATGCTCGTCAAGACCGTCGCGTTCGTAGCGCCCGTGTACC
TATTACTGCAAAAGTCGTTGCCGATTTCCTGTCTAGCGTGGGTGTTGACCGCGTTCTGACCTGTGACCTGCACGCTGAGC
AAATCCAAGGTTTCTTCGACGTTCCCGTTGATAACGTATTCGGTAGCCCAGTGCTGCTAGAAGATATGTTAGCGAAGAAC
TTAGATAATCCAGTCGTTGTTTCTCCAGACATCGGTGGTGTTGTTCGCGCTCGCGCAGTAGCAAAACTGTTGGATGATTC
TGATTTAGCGATCATTGATAAACGTCGCCCACAAGCAAACGTTGCTCAAGTTATGCACATCATTGGTGATGTTCAAGGTC
GTGACTGCATTATCGTTGACGATATGATCGACACAGGCGGCACTCTGTGTAAAGCGGCTGAAGCCTTAAAAGAACATGGT
GCGAACCGCGTATTTGCTTACGCAACTCACCCAGTGTTCTCTGGCAAAGCGGCTGAAAATATCGCTAACTCAGTGATTGA
TGAAGTGATTGTGACTGACACTGTTCCTTTAAGCCCAGAAATGTTGAAAGTGGCTAAAGTGACTCAGTTAACTATGTCTG
CGGTACTGGCTGAGGCAATTCGTCGCGTAAGCAACGAAGAGTCTATTTCTGCCATGTTCCGCCACTAA

Upstream 100 bases:

>100_bases
TAGAGTAACCACTTAACGATAACGCCTCGGGTTCCTCCCGTCCCTATATCGTCGTTACTCTAGCCACTAAAATATAAAGC
AAACGCCTGAGGTTCATACA

Downstream 100 bases:

>100_bases
TAGTTACGTCGCTAACAGTTCCGTTACTGAACGTTCTGACTAATCTGAGTGGTTCCGATGCACAGTGTGCTGTTTTAACG
AATCACTAAGCTTGCAGAGC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKN
LDNPVVVSPDIGGVVRARAVAKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHG
ANRVFAYATHPVFSGKAAENIANSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAIRRVSNEESISAMFRH

Sequences:

>Translated_315_residues
MPDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKN
LDNPVVVSPDIGGVVRARAVAKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHG
ANRVFAYATHPVFSGKAAENIANSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAIRRVSNEESISAMFRH
>Mature_314_residues
PDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKNL
DNPVVVSPDIGGVVRARAVAKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHGA
NRVFAYATHPVFSGKAAENIANSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAIRRVSNEESISAMFRH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=318, Percent_Identity=48.7421383647799, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI4506129, Length=318, Percent_Identity=47.7987421383648, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI84875539, Length=320, Percent_Identity=47.5, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI28557709, Length=318, Percent_Identity=47.4842767295598, Blast_Score=294, Evalue=8e-80,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=37.3913043478261, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=37.3913043478261, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=32.4137931034483, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=32.4137931034483, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=32.4137931034483, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=32.4137931034483, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=83.8095238095238, Blast_Score=551, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI25149168, Length=317, Percent_Identity=46.0567823343849, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17554702, Length=317, Percent_Identity=46.0567823343849, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=317, Percent_Identity=46.0567823343849, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=45.5128205128205, Blast_Score=283, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=34.7181008902077, Blast_Score=197, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=46.6666666666667, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=46.5189873417722, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321776, Length=319, Percent_Identity=47.9623824451411, Blast_Score=269, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=40.5797101449275, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=44.3478260869565, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21355239, Length=316, Percent_Identity=46.8354430379747, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=43.7869822485207, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI281362873, Length=357, Percent_Identity=34.733893557423, Blast_Score=200, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24651454, Length=357, Percent_Identity=34.733893557423, Blast_Score=200, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24651458, Length=357, Percent_Identity=34.733893557423, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651456, Length=357, Percent_Identity=34.733893557423, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651462, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24651464, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45552010, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34011; Mature: 33879

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTC
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKNLDNPVVVSPDIGGVVRARAV
CCCEEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
AKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHG
HHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCC
ANRVFAYATHPVFSGKAAENIANSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAI
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RRVSNEESISAMFRH
HHHCCHHHHHHHHCC
>Mature Secondary Structure 
PDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTC
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKNLDNPVVVSPDIGGVVRARAV
CCCEEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
AKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHG
HHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCC
ANRVFAYATHPVFSGKAAENIANSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAI
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RRVSNEESISAMFRH
HHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]