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The map label for this gene is pepA1 [H]

Identifier: 160876743

GI number: 160876743

Start: 4286291

End: 4287823

Strand: Direct

Name: pepA1 [H]

Synonym: Sbal195_3637

Alternate gene names: 160876743

Gene position: 4286291-4287823 (Clockwise)

Preceding gene: 160876742

Following gene: 160876744

Centisome position: 80.16

GC content: 51.14

Gene sequence:

>1533_bases
ATGAAAAATAAGCACAAATTTATGTTAAGCGTTATGGCTCTGGCGTGCCTTAACTCTCTCAATGCTAACGCCGAGATTTT
TAGTTTTGACACTCGTAGCTCACTGAATTCAGATACATTAGTGCTATTCCAAAGCGCTGATTCTACTACCTATGGGATCG
ATTTTTTACCTCAGTCGACCCAAGACCAATTAAACCTAGCGACAGCAGATAACAGCTTTTCCGGTAAGCAAGGTGAAATC
CTCGAGATTTTAGTGCCGAGCGAAATCGATGCTAAGCGAGTCTTACTGGTCGGCATTGGCGATGCAAAAACCCTAACGCC
CGGTGATATCAATACAATCGGCGGTAATGTTGCTGCCAAACTCGATACGGTTCCCCAAGCTACAGTACGCGTACTCACCC
AAGGTTTAACGGCCGCGCCGTTATTTGCCTCAGAGCTGGCCCACGGTATTGAACTGCGCAGTTATCGCTACACTCAGTTC
AAGGCGAGTACCCATGCCGAGAAGAACTACCAAATCGCCGTCGATGATTTAAGTGGCAACCAGAAACACCATAAAAATCT
GCAAGCGGTTGAAGCAGGTGTGTTTTTAGCCCGCGATCTTACTAACGCGCCCGCGGGCATTATGTATCCCGACAGCTTTG
CCAATGAGGCGAGAAAACTCAAATCCCTCGGCGTTAAAGTCACAGTATTAGAAGCCAAAGATATCGAACGCCTACAACTG
GGCGCCTTGGCGGCAGTAGGTAAAGGCAGCGAACGCCCACCTAAGTTAGTGGTCGCCCATTGGCCGGGCAGCAAAGATGC
GCCAATCGCACTGGTCGGTAAAGGTATCACCTTCGACTCTGGCGGTTACAACATTAAGGCGACGGGCACTTCTATCGCAC
GGATGAAGTCAGACATGGCGGGCGCAGCCACTGTGCTTGGCACCATCAAAGCCATGGCACTCCAAAAGGCGCCAGTCAAC
GTAGTCGCGATTATGCCGATGGCGGAGAACATGATCTCTGGCCACGCGATGATCCCAGGGGACGTGATTAAAACTGCCCA
AGGGCTCACCGTTGAAGTGCTCAATACCGATGCCGAAGGTCGCTTAGTGCTGGCCGATGGTCTCTGGTATGCCAGAGAAA
ACTATAAGCCTTCCATCATAGTGGATGTCGCGACCTTAACGGGTTCTAAAGTCGGCGCACTCGGCAGCGTGTATGCGGGA
TTGTTTACCGACTCAGAAACCTTGGTTCAGCAGTTAACCTATGCGGGACAACAGGTTGGCGAGAAAGTGTGGCGTCTACC
CTTAGATCAAGCCTACGATGATGAGCTTAAATCCACTATCGCGGATCTGAAAAACACCGGAAAAGAAGGCAGCGCAGGCG
CTTCCTCTGCGGCCATGTTCTTAAAACGCTTTGCGGGCGAACAGCCTTGGGCACATCTCGATATCGCGGGTAATGCCTTA
ACCGCCACCGATACCGCCGTTGTTCCTGCGGGCGCCACAGGTTACGGCGTGCGCTTGCTAAGCACTTGGTTAACTCAACC
TAAAGCTAAGTAA

Upstream 100 bases:

>100_bases
CTTGGATTTAATATTAATATCAGCAAAATAGCTTAAATTAGTTAACCCTAAGGCTGAGCTTTGATATTCTTCTCACACTC
CTATGATATGAGCTGTCACC

Downstream 100 bases:

>100_bases
CCTGAGCTCGGGATAAGCAGAGCCGCTGAATAGGCATCTTTTCGGGCCTCTCTGCGTTGCTCTGTCTAACCATAGCTCGC
TATGGCGTACGACAGAGCGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase 1; LAP 1; Leucyl aminopeptidase 1 [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKNKHKFMLSVMALACLNSLNANAEIFSFDTRSSLNSDTLVLFQSADSTTYGIDFLPQSTQDQLNLATADNSFSGKQGEI
LEILVPSEIDAKRVLLVGIGDAKTLTPGDINTIGGNVAAKLDTVPQATVRVLTQGLTAAPLFASELAHGIELRSYRYTQF
KASTHAEKNYQIAVDDLSGNQKHHKNLQAVEAGVFLARDLTNAPAGIMYPDSFANEARKLKSLGVKVTVLEAKDIERLQL
GALAAVGKGSERPPKLVVAHWPGSKDAPIALVGKGITFDSGGYNIKATGTSIARMKSDMAGAATVLGTIKAMALQKAPVN
VVAIMPMAENMISGHAMIPGDVIKTAQGLTVEVLNTDAEGRLVLADGLWYARENYKPSIIVDVATLTGSKVGALGSVYAG
LFTDSETLVQQLTYAGQQVGEKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
TATDTAVVPAGATGYGVRLLSTWLTQPKAK

Sequences:

>Translated_510_residues
MKNKHKFMLSVMALACLNSLNANAEIFSFDTRSSLNSDTLVLFQSADSTTYGIDFLPQSTQDQLNLATADNSFSGKQGEI
LEILVPSEIDAKRVLLVGIGDAKTLTPGDINTIGGNVAAKLDTVPQATVRVLTQGLTAAPLFASELAHGIELRSYRYTQF
KASTHAEKNYQIAVDDLSGNQKHHKNLQAVEAGVFLARDLTNAPAGIMYPDSFANEARKLKSLGVKVTVLEAKDIERLQL
GALAAVGKGSERPPKLVVAHWPGSKDAPIALVGKGITFDSGGYNIKATGTSIARMKSDMAGAATVLGTIKAMALQKAPVN
VVAIMPMAENMISGHAMIPGDVIKTAQGLTVEVLNTDAEGRLVLADGLWYARENYKPSIIVDVATLTGSKVGALGSVYAG
LFTDSETLVQQLTYAGQQVGEKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
TATDTAVVPAGATGYGVRLLSTWLTQPKAK
>Mature_510_residues
MKNKHKFMLSVMALACLNSLNANAEIFSFDTRSSLNSDTLVLFQSADSTTYGIDFLPQSTQDQLNLATADNSFSGKQGEI
LEILVPSEIDAKRVLLVGIGDAKTLTPGDINTIGGNVAAKLDTVPQATVRVLTQGLTAAPLFASELAHGIELRSYRYTQF
KASTHAEKNYQIAVDDLSGNQKHHKNLQAVEAGVFLARDLTNAPAGIMYPDSFANEARKLKSLGVKVTVLEAKDIERLQL
GALAAVGKGSERPPKLVVAHWPGSKDAPIALVGKGITFDSGGYNIKATGTSIARMKSDMAGAATVLGTIKAMALQKAPVN
VVAIMPMAENMISGHAMIPGDVIKTAQGLTVEVLNTDAEGRLVLADGLWYARENYKPSIIVDVATLTGSKVGALGSVYAG
LFTDSETLVQQLTYAGQQVGEKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
TATDTAVVPAGATGYGVRLLSTWLTQPKAK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=336, Percent_Identity=42.2619047619048, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI47155554, Length=317, Percent_Identity=38.1703470031546, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1790710, Length=463, Percent_Identity=35.4211663066955, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=43.5736677115987, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=315, Percent_Identity=38.7301587301587, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17565172, Length=339, Percent_Identity=28.6135693215339, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24661038, Length=320, Percent_Identity=35, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI21355725, Length=320, Percent_Identity=35, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24662227, Length=382, Percent_Identity=32.9842931937173, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI161077148, Length=352, Percent_Identity=34.0909090909091, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20130057, Length=352, Percent_Identity=34.0909090909091, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20129969, Length=366, Percent_Identity=33.0601092896175, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21355645, Length=380, Percent_Identity=32.6315789473684, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24662223, Length=380, Percent_Identity=32.6315789473684, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21357381, Length=316, Percent_Identity=37.0253164556962, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI221379063, Length=316, Percent_Identity=37.0253164556962, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI221379062, Length=316, Percent_Identity=37.0253164556962, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI20129963, Length=344, Percent_Identity=33.7209302325581, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI19922386, Length=363, Percent_Identity=30.5785123966942, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646701, Length=258, Percent_Identity=31.7829457364341, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24646703, Length=258, Percent_Identity=31.7829457364341, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21358201, Length=258, Percent_Identity=31.7829457364341, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54005; Mature: 54005

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKHKFMLSVMALACLNSLNANAEIFSFDTRSSLNSDTLVLFQSADSTTYGIDFLPQST
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCC
QDQLNLATADNSFSGKQGEILEILVPSEIDAKRVLLVGIGDAKTLTPGDINTIGGNVAAK
CCCEEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEE
LDTVPQATVRVLTQGLTAAPLFASELAHGIELRSYRYTQFKASTHAEKNYQIAVDDLSGN
ECCCCHHHHHHHHCCCCCCHHHHHHHHCCEEEEEEEEEEEECCCCCCCCCEEEEECCCCC
QKHHKNLQAVEAGVFLARDLTNAPAGIMYPDSFANEARKLKSLGVKVTVLEAKDIERLQL
HHHHCCHHHHHHHHHEEHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
GALAAVGKGSERPPKLVVAHWPGSKDAPIALVGKGITFDSGGYNIKATGTSIARMKSDMA
HHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEECCEEECCCCCEEEECCCHHHHHHHHHH
GAATVLGTIKAMALQKAPVNVVAIMPMAENMISGHAMIPGDVIKTAQGLTVEVLNTDAEG
HHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCC
RLVLADGLWYARENYKPSIIVDVATLTGSKVGALGSVYAGLFTDSETLVQQLTYAGQQVG
CEEEECCEEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCEE
TATDTAVVPAGATGYGVRLLSTWLTQPKAK
ECCCCEEECCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKNKHKFMLSVMALACLNSLNANAEIFSFDTRSSLNSDTLVLFQSADSTTYGIDFLPQST
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCC
QDQLNLATADNSFSGKQGEILEILVPSEIDAKRVLLVGIGDAKTLTPGDINTIGGNVAAK
CCCEEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEE
LDTVPQATVRVLTQGLTAAPLFASELAHGIELRSYRYTQFKASTHAEKNYQIAVDDLSGN
ECCCCHHHHHHHHCCCCCCHHHHHHHHCCEEEEEEEEEEEECCCCCCCCCEEEEECCCCC
QKHHKNLQAVEAGVFLARDLTNAPAGIMYPDSFANEARKLKSLGVKVTVLEAKDIERLQL
HHHHCCHHHHHHHHHEEHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
GALAAVGKGSERPPKLVVAHWPGSKDAPIALVGKGITFDSGGYNIKATGTSIARMKSDMA
HHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEECCEEECCCCCEEEECCCHHHHHHHHHH
GAATVLGTIKAMALQKAPVNVVAIMPMAENMISGHAMIPGDVIKTAQGLTVEVLNTDAEG
HHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCC
RLVLADGLWYARENYKPSIIVDVATLTGSKVGALGSVYAGLFTDSETLVQQLTYAGQQVG
CEEEECCEEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCEE
TATDTAVVPAGATGYGVRLLSTWLTQPKAK
ECCCCEEECCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]