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The map label for this gene is mazG [H]

Identifier: 160876387

GI number: 160876387

Start: 3862540

End: 3863451

Strand: Reverse

Name: mazG [H]

Synonym: Sbal195_3281

Alternate gene names: 160876387

Gene position: 3863451-3862540 (Counterclockwise)

Preceding gene: 160876390

Following gene: 160876386

Centisome position: 72.25

GC content: 49.01

Gene sequence:

>912_bases
ATGACTTCCCACACTGAGCCATTAACTTCATTTTCGACCTCGGGACTTTCTGCGACGAGCCTTTCTGTAACGGGCCTTTC
TGCTACAGATGTTGAGCCGCTGCTTAAGATCATGGAAAAATTGCGCGACCCACAAACAGGTTGCCCGTGGGATAAAGCGC
AAACGTTTCAAACCATAGTGCCTTTTACCTTAGAGGAAGCCTATGAGGTTGCCGATACCATAGAGCGCTTAGCCTGGGAT
GAGTTACCCGATGAACTTGGGGATTTATTATTTCAAATCGTATTCTATTGTCAGCTCGGTAAAGAGCAGGGGCTGTTTGA
TTTTGCCACAGTGATAGAGAAAATCAGCGACAAGTTAACCCGCCGTCATCCCCATGTGTTTGGCGAGAAAAATCCGCAAA
TAGGCGATAGCGCCCAAGCAATGAAAGCCAATTGGGAGGCGATTAAAGCGACTGAGCGTGAACAAAAGGCGCAGCAAGTG
GCGGGTGAAACCCAAGCTGATACTGTGGTTTCTGCGTTAGACAATATTCCGCGTACCCAACCTGCGCTGTCGCGCTCAAT
CAAAATTCAGCAAAGGGTGGCGCGAGTCGGTTTCGATTGGGCCGAACTTGAGCCCGTGGTCGCTAAAATCCACGAAGAAA
TCGATGAAGTCTTGCATGAAGTGAATCAACCCGAGCAAGACCAAGCGAAAGTGCAGTCCGAAATGGGCGACTTGCTATTT
GCCGTAGTGAATCTAGCCCGTCATCTTAAGGTCGATCCAGAGCAAGCGCTGCGCCAAGCCAATCTTAAATTTGAACGCCG
TTTTCGCGGTGTAGAACAGTTGGCGAGTGAGAGCGGTAAAAGCATGCAAGAGCACACATTAATGGAGCTTGATGCCTATT
GGGACCAAGTAAAAGCGACAGAGACGAGATAA

Upstream 100 bases:

>100_bases
CGTTATTATTGCCTTTTACTAACAAGCACTGCTGAGGCGTATTCTTTTGTTCATCCTCAGCACTAGCCCGTTTAAATATT
TATCTTTTAAGGATATCAGC

Downstream 100 bases:

>100_bases
ACGGCAAATTATCCCGATTGGTGTTTGTCGAATCGCGCCGCCTTTGGTATACTACTGCCCCGTCCTAGTGCTTTCTTACA
AGCACGTATTTTCAAACTCA

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTSHTEPLTSFSTSGLSATSLSVTGLSATDVEPLLKIMEKLRDPQTGCPWDKAQTFQTIVPFTLEEAYEVADTIERLAWD
ELPDELGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLTRRHPHVFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQV
AGETQADTVVSALDNIPRTQPALSRSIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLF
AVVNLARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKATETR

Sequences:

>Translated_303_residues
MTSHTEPLTSFSTSGLSATSLSVTGLSATDVEPLLKIMEKLRDPQTGCPWDKAQTFQTIVPFTLEEAYEVADTIERLAWD
ELPDELGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLTRRHPHVFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQV
AGETQADTVVSALDNIPRTQPALSRSIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLF
AVVNLARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKATETR
>Mature_302_residues
TSHTEPLTSFSTSGLSATSLSVTGLSATDVEPLLKIMEKLRDPQTGCPWDKAQTFQTIVPFTLEEAYEVADTIERLAWDE
LPDELGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLTRRHPHVFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQVA
GETQADTVVSALDNIPRTQPALSRSIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLFA
VVNLARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKATETR

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=271, Percent_Identity=54.2435424354244, Blast_Score=288, Evalue=3e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 34161; Mature: 34030

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHTEPLTSFSTSGLSATSLSVTGLSATDVEPLLKIMEKLRDPQTGCPWDKAQTFQTIV
CCCCCCCHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
PFTLEEAYEVADTIERLAWDELPDELGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLT
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RRHPHVFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQVAGETQADTVVSALDNIPRTQ
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
PALSRSIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AVVNLARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKAT
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
ETR
CCC
>Mature Secondary Structure 
TSHTEPLTSFSTSGLSATSLSVTGLSATDVEPLLKIMEKLRDPQTGCPWDKAQTFQTIV
CCCCCCHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
PFTLEEAYEVADTIERLAWDELPDELGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLT
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RRHPHVFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQVAGETQADTVVSALDNIPRTQ
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
PALSRSIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AVVNLARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKAT
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
ETR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]