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The map label for this gene is mmuM [H]

Identifier: 160876349

GI number: 160876349

Start: 3816778

End: 3817680

Strand: Reverse

Name: mmuM [H]

Synonym: Sbal195_3243

Alternate gene names: 160876349

Gene position: 3817680-3816778 (Counterclockwise)

Preceding gene: 160876350

Following gene: 160876348

Centisome position: 71.39

GC content: 55.48

Gene sequence:

>903_bases
ATGGATAAGCAGCAACTGTGGGTTTTGGATGGCGGCATGGGGCGTGAGTTGGCAAGACGGGGCGCACCCTTTCGCCAACC
TGAGTGGTCGGCATTGGCATTGATAGAAGCGCCGCAAACCGTGACTGAGGTACATCAAGCTTACGTAGCCAGCGGTGCCA
AAGTCATCACCACCAACAGTTATGCACTCGTGCCATTTCATATCGGCGATGAGCGTTTTGCCGCCGAGGGTGAAGTACTG
GCTGCATTGGCGGGCAAACTGGCACGGGATGTCGTGGATGAACACGCAAATGCGGTTCGCGTCGCGGGCTCATTGCCACC
CTTGTTTGGCTCTTACCGTGCCGATTTATTTGATGCCGCGAGGGTGAGTGAGTTGGCGCTCCCACTCATTCGAGCGTTGT
CGCCCAGTATCGATCTCTGGTTAGCCGAAACCATGAGTTTGATTGCCGAGCCTTTAGCCATCAAGGCCTTGCTGCCAGAA
GATGGCAAACCATTTTGGGTTTCTTTTACCTTAGAGGACGAGACGTTAGGTAGCGAACCGACACTTCGCTCCGGTGAGCG
GGTGGCAGATGCTATCGACGCGTTAGTAGCAGTCGGTGTGGATGCGATTCTGTTCAACTGTTGTCAGCCTGAGGTGATTG
AGGCGGCATTACAGGTGGCCAGCGATAGATTGAGTGCTCTGGGGCGTGCCGATATTCGACTCGGTGCCTATGCCAATGCA
TTTCCTCCTCAGCCGAAAGAGGCAACGGCTAACGATGGTCTGGATGAGATCCGTGCCGATCTTGGGCCGCTTGATTATCT
CGGTTGGGCTGAGCGTTGGCGCGCGGTAGGGGCTTCGCTTATCGGTGGTTGCTGCGGCATTGGTCCCGAACACATTCAGG
CTCTTTCTACTCGTTTGCGCTAA

Upstream 100 bases:

>100_bases
TGTCGTCATCGAACGCAGCAAGGTGCTAGGTCGCAGGATTCTCATTAACTATGAGTGCTTTAGTAAAACGAAGTCGCATA
AAAAGATTGAGGTAAGCAAG

Downstream 100 bases:

>100_bases
GGATTTTGTATGAAAGAGAACAGGATAGGTCTCTGGTCACTCACAGCCCTAGTGTTCAGCTCTATGGTAGGTGCGGGGAT
TTTTAGCCTGCCGCAAAACA

Product: homocysteine S-methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MDKQQLWVLDGGMGRELARRGAPFRQPEWSALALIEAPQTVTEVHQAYVASGAKVITTNSYALVPFHIGDERFAAEGEVL
AALAGKLARDVVDEHANAVRVAGSLPPLFGSYRADLFDAARVSELALPLIRALSPSIDLWLAETMSLIAEPLAIKALLPE
DGKPFWVSFTLEDETLGSEPTLRSGERVADAIDALVAVGVDAILFNCCQPEVIEAALQVASDRLSALGRADIRLGAYANA
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALSTRLR

Sequences:

>Translated_300_residues
MDKQQLWVLDGGMGRELARRGAPFRQPEWSALALIEAPQTVTEVHQAYVASGAKVITTNSYALVPFHIGDERFAAEGEVL
AALAGKLARDVVDEHANAVRVAGSLPPLFGSYRADLFDAARVSELALPLIRALSPSIDLWLAETMSLIAEPLAIKALLPE
DGKPFWVSFTLEDETLGSEPTLRSGERVADAIDALVAVGVDAILFNCCQPEVIEAALQVASDRLSALGRADIRLGAYANA
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALSTRLR
>Mature_300_residues
MDKQQLWVLDGGMGRELARRGAPFRQPEWSALALIEAPQTVTEVHQAYVASGAKVITTNSYALVPFHIGDERFAAEGEVL
AALAGKLARDVVDEHANAVRVAGSLPPLFGSYRADLFDAARVSELALPLIRALSPSIDLWLAETMSLIAEPLAIKALLPE
DGKPFWVSFTLEDETLGSEPTLRSGERVADAIDALVAVGVDAILFNCCQPEVIEAALQVASDRLSALGRADIRLGAYANA
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALSTRLR

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786456, Length=321, Percent_Identity=32.398753894081, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 32117; Mature: 32117

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQQLWVLDGGMGRELARRGAPFRQPEWSALALIEAPQTVTEVHQAYVASGAKVITTNS
CCCCEEEEEECCCCHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECC
YALVPFHIGDERFAAEGEVLAALAGKLARDVVDEHANAVRVAGSLPPLFGSYRADLFDAA
EEEEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHH
RVSELALPLIRALSPSIDLWLAETMSLIAEPLAIKALLPEDGKPFWVSFTLEDETLGSEP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEEECCCCCCCC
TLRSGERVADAIDALVAVGVDAILFNCCQPEVIEAALQVASDRLSALGRADIRLGAYANA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALSTRLR
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDKQQLWVLDGGMGRELARRGAPFRQPEWSALALIEAPQTVTEVHQAYVASGAKVITTNS
CCCCEEEEEECCCCHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECC
YALVPFHIGDERFAAEGEVLAALAGKLARDVVDEHANAVRVAGSLPPLFGSYRADLFDAA
EEEEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHH
RVSELALPLIRALSPSIDLWLAETMSLIAEPLAIKALLPEDGKPFWVSFTLEDETLGSEP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEEECCCCCCCC
TLRSGERVADAIDALVAVGVDAILFNCCQPEVIEAALQVASDRLSALGRADIRLGAYANA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALSTRLR
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]