Click here to switch to the map view.

The map label for this gene is tpx [H]

Identifier: 160876278

GI number: 160876278

Start: 3746752

End: 3747345

Strand: Direct

Name: tpx [H]

Synonym: Sbal195_3172

Alternate gene names: 160876278

Gene position: 3746752-3747345 (Clockwise)

Preceding gene: 160876277

Following gene: 160876281

Centisome position: 70.07

GC content: 44.11

Gene sequence:

>594_bases
ATGCAAAAATACGTTTCATTTTTAGCCGCCAGCTGTATTTATGGCTTAGTGCTGATGAGCCCCAATGTGCTTGCCAGTGA
GAAAAACCAGGTTCTTATGGGTGAAAAAACCGTCACCTTGGAAGGCAAGTTACCTAAGCTGTCGCAAATGGCGCCAGGAT
TCAAAGTGGTTGATGATCATTTTGCGCCAGTTATGCTAAGCGACTTTAAGGGTAAAACCGTGCTGATAAGTGCCGTACCA
AGCTTAGATACGGGCGTGTGTGCACTACAAACTAAACGTTTCAACAGCGAAGTAGGCCATTTTTCCGATGACGTGGTCAT
GCTAACCATCAGTGCCGATTTACCCTTCGCACAGAAACGTTTCTGCAAAGTAGAAAACGTAGATAAAATCAAAGTACTAT
CCGATTCCGTCTGGCGTGATTTTGGTGAAAAATATGGCTTGTTGATTCAAGATTACGGCTTGCTCGCGAGAGCTATTTTC
ATCATAGATGCCGAAGGTAAACTCCAATACCAAGAGTTAGTACCGAATATCACCGAGCATCCTAACTATGATGCCGCACT
TGAAGCGCTGAAAACCATTCAAGCACAGCAGTAA

Upstream 100 bases:

>100_bases
GCAATTGCCGGCCTTTTTTTATGGTTCTGCATAGCATTTTAGCGTACCTTAAAGGACAGATATTAGCGAAGGCACAGATA
TTCATGTGCGAGGAAATCCA

Downstream 100 bases:

>100_bases
TTTACCGCTAAAAAACAGGGCAGCCTTAGCTGCCCTTTTGTTTTACGATTGTATATCTACGATTTGGTTTTACGATCTAA
TGTGTGTGCTGATCGCCATT

Product: redoxin domain-containing protein

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MQKYVSFLAASCIYGLVLMSPNVLASEKNQVLMGEKTVTLEGKLPKLSQMAPGFKVVDDHFAPVMLSDFKGKTVLISAVP
SLDTGVCALQTKRFNSEVGHFSDDVVMLTISADLPFAQKRFCKVENVDKIKVLSDSVWRDFGEKYGLLIQDYGLLARAIF
IIDAEGKLQYQELVPNITEHPNYDAALEALKTIQAQQ

Sequences:

>Translated_197_residues
MQKYVSFLAASCIYGLVLMSPNVLASEKNQVLMGEKTVTLEGKLPKLSQMAPGFKVVDDHFAPVMLSDFKGKTVLISAVP
SLDTGVCALQTKRFNSEVGHFSDDVVMLTISADLPFAQKRFCKVENVDKIKVLSDSVWRDFGEKYGLLIQDYGLLARAIF
IIDAEGKLQYQELVPNITEHPNYDAALEALKTIQAQQ
>Mature_197_residues
MQKYVSFLAASCIYGLVLMSPNVLASEKNQVLMGEKTVTLEGKLPKLSQMAPGFKVVDDHFAPVMLSDFKGKTVLISAVP
SLDTGVCALQTKRFNSEVGHFSDDVVMLTISADLPFAQKRFCKVENVDKIKVLSDSVWRDFGEKYGLLIQDYGLLARAIF
IIDAEGKLQYQELVPNITEHPNYDAALEALKTIQAQQ

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=157, Percent_Identity=39.4904458598726, Blast_Score=114, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17738015, Length=205, Percent_Identity=29.7560975609756, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 21821; Mature: 21821

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKYVSFLAASCIYGLVLMSPNVLASEKNQVLMGEKTVTLEGKLPKLSQMAPGFKVVDDH
CHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCEEEEECCCCCCHHHHCCCCEEECCC
FAPVMLSDFKGKTVLISAVPSLDTGVCALQTKRFNSEVGHFSDDVVMLTISADLPFAQKR
CCCEEEECCCCCEEEEEECCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCHHHHH
FCKVENVDKIKVLSDSVWRDFGEKYGLLIQDYGLLARAIFIIDAEGKLQYQELVPNITEH
HHCCCCCCCEEHHHHHHHHHHHHHCCEEEEHHHHHEEEEEEEECCCCEEHHHHCCCCCCC
PNYDAALEALKTIQAQQ
CCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKYVSFLAASCIYGLVLMSPNVLASEKNQVLMGEKTVTLEGKLPKLSQMAPGFKVVDDH
CHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCEEEEECCCCCCHHHHCCCCEEECCC
FAPVMLSDFKGKTVLISAVPSLDTGVCALQTKRFNSEVGHFSDDVVMLTISADLPFAQKR
CCCEEEECCCCCEEEEEECCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCHHHHH
FCKVENVDKIKVLSDSVWRDFGEKYGLLIQDYGLLARAIFIIDAEGKLQYQELVPNITEH
HHCCCCCCCEEHHHHHHHHHHHHHCCEEEEHHHHHEEEEEEEECCCCEEHHHHCCCCCCC
PNYDAALEALKTIQAQQ
CCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA