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The map label for this gene is hisS [H]

Identifier: 160876253

GI number: 160876253

Start: 3721139

End: 3722419

Strand: Reverse

Name: hisS [H]

Synonym: Sbal195_3147

Alternate gene names: 160876253

Gene position: 3722419-3721139 (Counterclockwise)

Preceding gene: 160876254

Following gene: 160876252

Centisome position: 69.61

GC content: 47.38

Gene sequence:

>1281_bases
GTGGCAAAACAGATCCAAGCGATTCGCGGAATGAATGACATTCTGCCAACTCAAAGTCCTCTATGGCAAAAAATGGAAGC
GGTACTACGTTCGAGCGTCAGTGCTTACGGTTACAGCGAAATCCGCACTCCAATAGTGGAAAATACCGATCTCTTTAAAC
GCTCTATCGGTGAAGTGACTGATATTGTTGAAAAAGAAATGTATACCTTCGCAGATAATAACGGTGATAGCTTAACGCTG
CGCCCAGAAGGTACGGCATCGACAGTGCGTGCGGGTAACGAAAACGGTCTGCTGTATAACCAAGAACAACGTCTTTGGTA
TATGGGTCCTATGTTCCGCCACGAGCGTCCACAAAAAGGCCGTTATCGCCAATTTAACCAATTTGGCGTGGAAGTGTATG
GCATAGGCACGGCGGATATTGATGCTGAAGTCTTGATGCTATCGGCACGCCTGTGGGAAAAACTCGGTATTAGCGATCAC
GTATCGTTAGAGCTGAACACCTTAGGCGATCCCGCTGAGCGCGCGGTTTACCGTGATGCCTTGATTGCGTTTTTAGAGCA
GCATAAAGATGCGCTCGATGAAGACAGCAAGCGTCGCATGTACAGCAATCCGCTGCGAGTATTGGATTCAAAAGACCAAA
ATGTCCAAGCTATTTTGGCTGGTGCACCTGAGTTGATGGATTTCCTCGGTGAAGAATCGAAGACACATTTTTCACAATTG
CGTGAACTACTTGACGCAGTGGGTATCAAATACACCATTAATCCGCGCCTTGTTCGTGGTTTAGATTACTATAATCGCAC
TGTATTTGAATGGGTTACATCGAGTTTAGGCTCGCAAGGTACAGTACTTGCGGGTGGCCGCTACGACGGCTTAGTTGCCC
AATTAGGTGGTAAAGATACCCCTGCGGTGGGTTTCGCTATGGGCTTAGAGCGCATTGTCTTGCTGCTTGAAACCTTAGAG
CTAAACAAAGATATTCCGTCAGAAGTGGATGTGTATGTCACTGCCATGGGTGATAGCTGTCTGGTTGAAGCGATTAAAAT
TGCGCAGGAATTACGCAGCGCGCTGCCAAACCTTAAAGTGATGAGTCACTGCGGTGGCGGCAACGTGAAGAAACAAATGA
AACGTGCCGACAAAAGCGGTGCGAGTGTGGCGTTACTGATAGGCGAAGATGAACTTGCCGAAGGTATGGTGACGGTTAAA
CATTTACGCAATGACATCGAACAACAACGGGTAGCTCGAAGTGCCTTAGGTGCATTTTTAGCTGAACTGGCCATTAAGTA
A

Upstream 100 bases:

>100_bases
TAGGCCCCGAAACCGACGGGGTCGTTTTACGTTTTACGTTCAAAAGCCTATAATGCGTGACATTTTTTATTAATTTAGCT
AAATCGGACGAGTCGATACA

Downstream 100 bases:

>100_bases
TAGATCATATAAGGGGACGTGCGCGTGGAAATTTATAGCACAGAAGAACAACAAGTTGATGCTATCAAGCAGTTCTGGAA
AGACTATGGAACCTCGATTT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAKQIQAIRGMNDILPTQSPLWQKMEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVTDIVEKEMYTFADNNGDSLTL
RPEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDH
VSLELNTLGDPAERAVYRDALIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQL
RELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDTPAVGFAMGLERIVLLLETLE
LNKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKVMSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVK
HLRNDIEQQRVARSALGAFLAELAIK

Sequences:

>Translated_426_residues
MAKQIQAIRGMNDILPTQSPLWQKMEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVTDIVEKEMYTFADNNGDSLTL
RPEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDH
VSLELNTLGDPAERAVYRDALIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQL
RELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDTPAVGFAMGLERIVLLLETLE
LNKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKVMSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVK
HLRNDIEQQRVARSALGAFLAELAIK
>Mature_425_residues
AKQIQAIRGMNDILPTQSPLWQKMEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVTDIVEKEMYTFADNNGDSLTLR
PEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDHV
SLELNTLGDPAERAVYRDALIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQLR
ELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDTPAVGFAMGLERIVLLLETLEL
NKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKVMSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVKH
LRNDIEQQRVARSALGAFLAELAIK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15029520, Length=449, Percent_Identity=24.9443207126949, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI6996014, Length=459, Percent_Identity=25.2723311546841, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1788861, Length=423, Percent_Identity=64.7754137115839, Blast_Score=564, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71993693, Length=458, Percent_Identity=25.9825327510917, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71993686, Length=458, Percent_Identity=25.9825327510917, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325290, Length=456, Percent_Identity=25, Blast_Score=90, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47336; Mature: 47204

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQIQAIRGMNDILPTQSPLWQKMEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVT
CCCHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHH
DIVEKEMYTFADNNGDSLTLRPEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKG
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCCEECCCCCEEEECCHHHCCCCCCC
RYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDHVSLELNTLGDPAERAVYRDA
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
LIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQL
HHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCHHEEECCCHHHHHHHCCCCHHHHHHH
RELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDT
HHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHCCCCCC
PAVGFAMGLERIVLLLETLELNKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEE
MSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVKHLRNDIEQQRVARSALGAFL
HHCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELAIK
HHHHCC
>Mature Secondary Structure 
AKQIQAIRGMNDILPTQSPLWQKMEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVT
CCHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHH
DIVEKEMYTFADNNGDSLTLRPEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKG
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCCEECCCCCEEEECCHHHCCCCCCC
RYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDHVSLELNTLGDPAERAVYRDA
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
LIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQL
HHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCHHEEECCCHHHHHHHCCCCHHHHHHH
RELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDT
HHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHCCCCCC
PAVGFAMGLERIVLLLETLELNKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEE
MSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVKHLRNDIEQQRVARSALGAFL
HHCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELAIK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA