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The map label for this gene is hisC [H]

Identifier: 160875650

GI number: 160875650

Start: 3001395

End: 3002555

Strand: Direct

Name: hisC [H]

Synonym: Sbal195_2538

Alternate gene names: 160875650

Gene position: 3001395-3002555 (Clockwise)

Preceding gene: 160875649

Following gene: 160875651

Centisome position: 56.13

GC content: 51.25

Gene sequence:

>1161_bases
ATGAGCCAAGTGAGCAGCATGGAAAAGACAGCAGAACCCGCAGCATTAGTGCTTAATTTAGCCGAGCGCCTAGCGCGCCC
TGAGTTACTGGATTTAACGCCCTACCAGAGTGCCCGCAGACTGGGCGGTCGTGGTGATATTTGGATCAATGCCAACGAAT
CGCCCTTTAATAATGTCGATACCGCAGCGCTCGATTTATCAAAATTGAATCGTTACCCAGAATGCCAACCGCCGCAGCTT
ATCAATGCCTACAGCGAATACAGCGGCGTAAGCGCCAGCAAGATAGTCGCCAGCCGCGGCGCCGATGAAGCGATTGAACT
GTTAATTCGCGCCTTTTGTATACCAGGCGTCGACAGCATTGCCTGCTTTGGCCCGACGTACGGCATGTATGCCATCAGCG
CGAACACCTTTAATGTGGGCGTTAAAGCGTTAAATCTCAGTGCCGAATATGGCTTGCCGACAAGCTATGCCGAGGACGTT
CACGGCGCAAAACTGGTGTTTATCTGCAATCCAAATAATCCTACTGGGACTGTGATCGACAAAGCCATTATCGAGCAAGC
GATCAAAGCCCTGCCCGATTCGCTTGTGGTCATCGATGAGGCCTATATTGAGTTTTGCACTGAATACAGTGTGGCGGATT
TACTGGAAAGCTATCCGAATCTAGTGGTACTGCGCACCCTGTCAAAAGCTTTTGCACTCGCCGGCGCACGTTGTGGTTTT
ATGCTAGCAAACGAGGCCGTAGTCGAAATTATTATGCGCGTGATTGCGCCCTATCCTGTGCCGCTGCCAGTGAGTGAAGT
CGCCACCCAAGCGCTATCAAGCGCTGGCGTTGCGCGAATGAAAGTGCAAGTTGCACAATTAAATGAGCAAGGCGCCAGAC
TCACAGCGGCGATCAGCGCCTATTGTTCAAAATCGAATAGTTCAGATTCGCGCGCCCGCGTGCTTAAGCCTAACGGCAAT
TATGTACTGGCTGAATTTGATGATGTCGCCAAGGTCGCGGCGTTACTGCAAGGCAGCGGCGTTGTCGCCCGCGCCTACAA
AGACCCAAGGCTTGCCAAGGCTATCCGCTTTAGCTTTAGTTCTAAGGCGGATACCGATGTGTTAGTGAATTTATTTGAAT
CGCAACGCACTGAGCAGTCACCAGAAACGAATAATAAGTAA

Upstream 100 bases:

>100_bases
AAATGCCGTAGCCATTCGTCTAGCTAGCCTAGAGAAATGATTCGCCTAGATCTTAAATGATTAGCGCTTAAGTGATTGAA
AATATATGTGAGTGAAGAAA

Downstream 100 bases:

>100_bases
CTGAACATAAAAACTAATAAAACCAATAAAAAGCGAATGCCGCGCTGAAGGTAACATCAGCTTAAGCATTAGCTAAACGA
ATTGAATTTGAAGGTAGAGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSQVSSMEKTAEPAALVLNLAERLARPELLDLTPYQSARRLGGRGDIWINANESPFNNVDTAALDLSKLNRYPECQPPQL
INAYSEYSGVSASKIVASRGADEAIELLIRAFCIPGVDSIACFGPTYGMYAISANTFNVGVKALNLSAEYGLPTSYAEDV
HGAKLVFICNPNNPTGTVIDKAIIEQAIKALPDSLVVIDEAYIEFCTEYSVADLLESYPNLVVLRTLSKAFALAGARCGF
MLANEAVVEIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQLNEQGARLTAAISAYCSKSNSSDSRARVLKPNGN
YVLAEFDDVAKVAALLQGSGVVARAYKDPRLAKAIRFSFSSKADTDVLVNLFESQRTEQSPETNNK

Sequences:

>Translated_386_residues
MSQVSSMEKTAEPAALVLNLAERLARPELLDLTPYQSARRLGGRGDIWINANESPFNNVDTAALDLSKLNRYPECQPPQL
INAYSEYSGVSASKIVASRGADEAIELLIRAFCIPGVDSIACFGPTYGMYAISANTFNVGVKALNLSAEYGLPTSYAEDV
HGAKLVFICNPNNPTGTVIDKAIIEQAIKALPDSLVVIDEAYIEFCTEYSVADLLESYPNLVVLRTLSKAFALAGARCGF
MLANEAVVEIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQLNEQGARLTAAISAYCSKSNSSDSRARVLKPNGN
YVLAEFDDVAKVAALLQGSGVVARAYKDPRLAKAIRFSFSSKADTDVLVNLFESQRTEQSPETNNK
>Mature_385_residues
SQVSSMEKTAEPAALVLNLAERLARPELLDLTPYQSARRLGGRGDIWINANESPFNNVDTAALDLSKLNRYPECQPPQLI
NAYSEYSGVSASKIVASRGADEAIELLIRAFCIPGVDSIACFGPTYGMYAISANTFNVGVKALNLSAEYGLPTSYAEDVH
GAKLVFICNPNNPTGTVIDKAIIEQAIKALPDSLVVIDEAYIEFCTEYSVADLLESYPNLVVLRTLSKAFALAGARCGFM
LANEAVVEIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQLNEQGARLTAAISAYCSKSNSSDSRARVLKPNGNY
VLAEFDDVAKVAALLQGSGVVARAYKDPRLAKAIRFSFSSKADTDVLVNLFESQRTEQSPETNNK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=356, Percent_Identity=43.2584269662921, Blast_Score=288, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6322075, Length=310, Percent_Identity=33.2258064516129, Blast_Score=158, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41502; Mature: 41370

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVSSMEKTAEPAALVLNLAERLARPELLDLTPYQSARRLGGRGDIWINANESPFNNVD
CCCHHHHHHHCCHHHHHHHHHHHHCCCCEECCCCCHHHHHCCCCCCEEEECCCCCCCCCH
TAALDLSKLNRYPECQPPQLINAYSEYSGVSASKIVASRGADEAIELLIRAFCIPGVDSI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCE
ACFGPTYGMYAISANTFNVGVKALNLSAEYGLPTSYAEDVHGAKLVFICNPNNPTGTVID
EECCCCCCEEEEECCEEEECEEEEEEECCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHH
KAIIEQAIKALPDSLVVIDEAYIEFCTEYSVADLLESYPNLVVLRTLSKAFALAGARCGF
HHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCH
MLANEAVVEIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQLNEQGARLTAAISA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHH
YCSKSNSSDSRARVLKPNGNYVLAEFDDVAKVAALLQGSGVVARAYKDPRLAKAIRFSFS
HHCCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCC
SKADTDVLVNLFESQRTEQSPETNNK
CCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SQVSSMEKTAEPAALVLNLAERLARPELLDLTPYQSARRLGGRGDIWINANESPFNNVD
CCHHHHHHHCCHHHHHHHHHHHHCCCCEECCCCCHHHHHCCCCCCEEEECCCCCCCCCH
TAALDLSKLNRYPECQPPQLINAYSEYSGVSASKIVASRGADEAIELLIRAFCIPGVDSI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCE
ACFGPTYGMYAISANTFNVGVKALNLSAEYGLPTSYAEDVHGAKLVFICNPNNPTGTVID
EECCCCCCEEEEECCEEEECEEEEEEECCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHH
KAIIEQAIKALPDSLVVIDEAYIEFCTEYSVADLLESYPNLVVLRTLSKAFALAGARCGF
HHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCH
MLANEAVVEIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQLNEQGARLTAAISA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHH
YCSKSNSSDSRARVLKPNGNYVLAEFDDVAKVAALLQGSGVVARAYKDPRLAKAIRFSFS
HHCCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCC
SKADTDVLVNLFESQRTEQSPETNNK
CCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]