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The map label for this gene is hisG

Identifier: 160875648

GI number: 160875648

Start: 2999130

End: 3000029

Strand: Direct

Name: hisG

Synonym: Sbal195_2536

Alternate gene names: 160875648

Gene position: 2999130-3000029 (Clockwise)

Preceding gene: 160875647

Following gene: 160875649

Centisome position: 56.09

GC content: 49.56

Gene sequence:

>900_bases
ATGACTGAATCGAACCGTTTACGCATCGCCATCCAAAAATCTGGCCGTCTTTCCACTGACTCTCAGCAACTGCTAAAAAG
CTGTGGTGTTAAATTTTCCATTAATGAACAACGCCTTATTGCTCACGCTGACAATATGCCTATCGATTTACTGCGCGTTC
GTGATGATGATATCCCAGGATTGGTGATGGACGGCGTGGTTGATATGGGGATTATCGGTGAAAACGTGCTCGAAGAAGAA
CAAATCGAGCGTCAAACCCTGAACAAGCCCGCAGATTGCCTCAAACTGCGTCAGTTGGATTTCGGCTCATGTCGCCTCTC
GTTAGCCGTACCAACAGAATTCAGTTATGCCGATGCCTCCTCTTTAGAAGGATTACGCATCGCCACTTCTTACCCGAACC
TGCTGCGCCGTTTTATGCAACAAAAAGGCATAACTTATCGCGACTGTATGTTAAAAGGCTCGGTTGAAGTCGCCCCACGT
GCCGGCCTTGCCGACGGTATTTGTGATCTTGTGTCGACGGGCGCAACCTTAGAAGCCAACGGTTTATACGAAACCGAAGT
AATTTACCGCTCTATGGCCTGCATCATTCAATCGACCCAAACCCAAACGCCGACAAAACAAGCACTCATCGACAAAATTC
TGTCCCGCGTCAATGGTGTTATCCGCGCCCGTGAGAGCAAATACATCCTGCTGCACGCGCCAACCGAAACCTTAGATCAA
ATCGTCGCCCTGCTGCCCGGCGCTGAAAACCCCACCGTATTGCCATTAAATGATGATACTAACCGCGTCGCTATCCACGC
CGTCAGTACCGAAGATTTGTTCTGGGATACCATGGAACAGCTGACCGCACTCGGTGCCAGCTCGATTCTGGTCATGCCAA
TCGAAAAAATGATGGGGTAA

Upstream 100 bases:

>100_bases
GCTCTTAGCTAGAGCCCATTGAACAGCAAGACGTATTAAACCGATTAAACAACACACTTTTGAATCTTTTAATTTTGATA
CTTTTGAGCGAGATAACACT

Downstream 100 bases:

>100_bases
TGTATGGAAATCCTAACTTGGTCAACCTTATCAACCGCCGAGCAGAAAACGGCGCTGAAACGCTCGCCCTTAATCGGTGA
CAGTGGCTTAGAGCAAAGCG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTESNRLRIAIQKSGRLSTDSQQLLKSCGVKFSINEQRLIAHADNMPIDLLRVRDDDIPGLVMDGVVDMGIIGENVLEEE
QIERQTLNKPADCLKLRQLDFGSCRLSLAVPTEFSYADASSLEGLRIATSYPNLLRRFMQQKGITYRDCMLKGSVEVAPR
AGLADGICDLVSTGATLEANGLYETEVIYRSMACIIQSTQTQTPTKQALIDKILSRVNGVIRARESKYILLHAPTETLDQ
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTALGASSILVMPIEKMMG

Sequences:

>Translated_299_residues
MTESNRLRIAIQKSGRLSTDSQQLLKSCGVKFSINEQRLIAHADNMPIDLLRVRDDDIPGLVMDGVVDMGIIGENVLEEE
QIERQTLNKPADCLKLRQLDFGSCRLSLAVPTEFSYADASSLEGLRIATSYPNLLRRFMQQKGITYRDCMLKGSVEVAPR
AGLADGICDLVSTGATLEANGLYETEVIYRSMACIIQSTQTQTPTKQALIDKILSRVNGVIRARESKYILLHAPTETLDQ
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTALGASSILVMPIEKMMG
>Mature_298_residues
TESNRLRIAIQKSGRLSTDSQQLLKSCGVKFSINEQRLIAHADNMPIDLLRVRDDDIPGLVMDGVVDMGIIGENVLEEEQ
IERQTLNKPADCLKLRQLDFGSCRLSLAVPTEFSYADASSLEGLRIATSYPNLLRRFMQQKGITYRDCMLKGSVEVAPRA
GLADGICDLVSTGATLEANGLYETEVIYRSMACIIQSTQTQTPTKQALIDKILSRVNGVIRARESKYILLHAPTETLDQI
VALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTALGASSILVMPIEKMMG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=298, Percent_Identity=67.4496644295302, Blast_Score=420, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6320896, Length=297, Percent_Identity=29.2929292929293, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SHEB2 (B8E9A5)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002357861.1
- ProteinModelPortal:   B8E9A5
- SMR:   B8E9A5
- GeneID:   7090100
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_1933
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32954; Mature: 32823

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESNRLRIAIQKSGRLSTDSQQLLKSCGVKFSINEQRLIAHADNMPIDLLRVRDDDIPG
CCCCCEEEEEEECCCCCCCCHHHHHHHCCCEEEECCCEEEEECCCCCEEEEEECCCCCCC
LVMDGVVDMGIIGENVLEEEQIERQTLNKPADCLKLRQLDFGSCRLSLAVPTEFSYADAS
HHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
SLEGLRIATSYPNLLRRFMQQKGITYRDCMLKGSVEVAPRAGLADGICDLVSTGATLEAN
CCCCEEEECCCHHHHHHHHHHCCCEEHHHEEECCCEECCCCCCHHHHHHHHHCCCEEECC
GLYETEVIYRSMACIIQSTQTQTPTKQALIDKILSRVNGVIRARESKYILLHAPTETLDQ
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEECCHHHHHH
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTALGASSILVMPIEKMMG
HHHHCCCCCCCEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure 
TESNRLRIAIQKSGRLSTDSQQLLKSCGVKFSINEQRLIAHADNMPIDLLRVRDDDIPG
CCCCEEEEEEECCCCCCCCHHHHHHHCCCEEEECCCEEEEECCCCCEEEEEECCCCCCC
LVMDGVVDMGIIGENVLEEEQIERQTLNKPADCLKLRQLDFGSCRLSLAVPTEFSYADAS
HHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
SLEGLRIATSYPNLLRRFMQQKGITYRDCMLKGSVEVAPRAGLADGICDLVSTGATLEAN
CCCCEEEECCCHHHHHHHHHHCCCEEHHHEEECCCEECCCCCCHHHHHHHHHCCCEEECC
GLYETEVIYRSMACIIQSTQTQTPTKQALIDKILSRVNGVIRARESKYILLHAPTETLDQ
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEECCHHHHHH
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTALGASSILVMPIEKMMG
HHHHCCCCCCCEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA