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The map label for this gene is mepA [H]

Identifier: 160875421

GI number: 160875421

Start: 2728799

End: 2730424

Strand: Direct

Name: mepA [H]

Synonym: Sbal195_2309

Alternate gene names: 160875421

Gene position: 2728799-2730424 (Clockwise)

Preceding gene: 160875419

Following gene: 160875422

Centisome position: 51.03

GC content: 45.51

Gene sequence:

>1626_bases
GTGAAACATGCAACAGCCAACACTTTCAAGCCCGCCAGTATCAATGTTGAACCTTCTGACATTGTGCCCTTTGCAGCCAC
CGAAACATCCTCCCACGGGAAATCTCATTCAGGCTTTCAGTCAAGATCTCAGTCAACAGACTCCTTAGGTACATTAGCTA
TCCCTGCTTTGTATTTACGTTTTGCGTTACCCATGGCCTTCGCCATGATGCTCAGCGGCAGCTACAACTTAGTCGACTCT
TATTTTATTTTGAAATACATCGGCGCCGATGCATTGGCTGGGGTAACGATTGCCTTCCCGTTACAAATGATGATTTTCGC
TTTAGCCTGCATGATAGGAAATGGGACTGCGACCTTAGTGAGCCGATTTTTAGGGGCAAACGAGTTTGATAAGGCGAGTC
AAATCGCGAACACCGGTTTCGCGTTAGCCCTATGTTGCGGCGTGATCGTCACTGTCGTGTCACTCGCCCAGCTCGATAAT
CTATTAGCGTTTATTGGGGTAAGCTCAACACTTGCCTTAGCTGCTACAGAGTATCTACAACCCATTCTCTGTTTTAGTCT
GTTCACCTTTTTGTTATCCCTTAGCGGCGATTTACTCAGAGCACAAGGCAAAGTCGTGGTGATGCTGCTGGTTATCTTGT
TGTCGGCGGTAATGAACATCCTGTTCGATACACTCTTTATTTCCGTATTGGAGATGGGCGTGAGTGGTGCGGCGTGGGCA
ACGGTAGCGGGCCAGTGTGTGAGTCTATTTATCGCCGTCGTCTATTTTGTCCCAAATAACCGCTTTGCCAATAAGCAGGC
GCTTCATAAGCAAGCTGCCCAGCCTATTTGTTTTAGAAAAGAGCAAATAAAGCTCAACCTCACTGAGATAAAAGCGATTC
TTGGCTTGGGTAGCCCAATATTATTGTCATATCTTGGGATTGCCTGCGTGATCTCATTGGTAAATCATATTTTAGTCAGT
CATTTAGCCAATGTAGTGCCCAATACGCCAGCGGCGAATGAGGTCGCGTACATGATCAGCGCTTATGGTTTGATCGGCCG
CTTTAATATCTTTATCGCCCTGCCGCTCATGGCTCTCACCAGTGCAGCACAAACGATCAGTGCCTATAACTATGGGGCGA
TGGCATCATCTCGGGTGTTAGCGTGTGCTAAATGGGGAATCGTCTTGACCTGCTGTTATCTGAGTGTTGTGACAATCATA
TTTATGGGGTTTCCTACCTCAGTATTTGGTATTTTCACCGATAATCACTCACTGATTGCCGCCTGTATTAAGATTTCGAG
TGTGACGTTTATCGCCTTACCTTTGGCGGGGATCACAGGTATTGCGATTGCTGTGTATCAAGGCACAAACCGCCCTAAGC
TTGCATTGCTATTATCTGGGATAAAAATCTATGGTTTGTTATTGCCCCTGCTGGTCCTGTTACCTCAACTATCCTTTACA
GATATTTCATTTATCACAGGTGCATTAAACATTAATATCATGCGAAACGCTTTGATTGAGTTATGGATGGCCTTTCCAAT
TGCGGACATCTTAGCTTGTCTATTGAGTTTATTGATCATCAGTATTTGGCCTTTCATTCACGTGCCGCAAGCAAATAGAG
TCAGTCATGGAGGTAATGCAAAATGA

Upstream 100 bases:

>100_bases
CTGATAAATTAACAGCGTTGCGAATCGATTTCATATCGAACCCACAGCAATCAAATAAGTTTGACTTAGCGGAATGCCAA
TAAACTTAGGAGAATTGTTT

Downstream 100 bases:

>100_bases
AGTTAGCCAATATGAAAGACTCAAGCGCCATCGCATTAAATGAAACCAAAATTCGCGCTAAAAAGCTGCTCAAAGCTTGT
CAGCAGGATGAGCCATCTGC

Product: multi anti extrusion protein MatE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MKHATANTFKPASINVEPSDIVPFAATETSSHGKSHSGFQSRSQSTDSLGTLAIPALYLRFALPMAFAMMLSGSYNLVDS
YFILKYIGADALAGVTIAFPLQMMIFALACMIGNGTATLVSRFLGANEFDKASQIANTGFALALCCGVIVTVVSLAQLDN
LLAFIGVSSTLALAATEYLQPILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFISVLEMGVSGAAWA
TVAGQCVSLFIAVVYFVPNNRFANKQALHKQAAQPICFRKEQIKLNLTEIKAILGLGSPILLSYLGIACVISLVNHILVS
HLANVVPNTPAANEVAYMISAYGLIGRFNIFIALPLMALTSAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLSVVTII
FMGFPTSVFGIFTDNHSLIAACIKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLPQLSFT
DISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPQANRVSHGGNAK

Sequences:

>Translated_541_residues
MKHATANTFKPASINVEPSDIVPFAATETSSHGKSHSGFQSRSQSTDSLGTLAIPALYLRFALPMAFAMMLSGSYNLVDS
YFILKYIGADALAGVTIAFPLQMMIFALACMIGNGTATLVSRFLGANEFDKASQIANTGFALALCCGVIVTVVSLAQLDN
LLAFIGVSSTLALAATEYLQPILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFISVLEMGVSGAAWA
TVAGQCVSLFIAVVYFVPNNRFANKQALHKQAAQPICFRKEQIKLNLTEIKAILGLGSPILLSYLGIACVISLVNHILVS
HLANVVPNTPAANEVAYMISAYGLIGRFNIFIALPLMALTSAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLSVVTII
FMGFPTSVFGIFTDNHSLIAACIKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLPQLSFT
DISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPQANRVSHGGNAK
>Mature_541_residues
MKHATANTFKPASINVEPSDIVPFAATETSSHGKSHSGFQSRSQSTDSLGTLAIPALYLRFALPMAFAMMLSGSYNLVDS
YFILKYIGADALAGVTIAFPLQMMIFALACMIGNGTATLVSRFLGANEFDKASQIANTGFALALCCGVIVTVVSLAQLDN
LLAFIGVSSTLALAATEYLQPILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFISVLEMGVSGAAWA
TVAGQCVSLFIAVVYFVPNNRFANKQALHKQAAQPICFRKEQIKLNLTEIKAILGLGSPILLSYLGIACVISLVNHILVS
HLANVVPNTPAANEVAYMISAYGLIGRFNIFIALPLMALTSAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLSVVTII
FMGFPTSVFGIFTDNHSLIAACIKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLPQLSFT
DISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPQANRVSHGGNAK

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 57682; Mature: 57682

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHATANTFKPASINVEPSDIVPFAATETSSHGKSHSGFQSRSQSTDSLGTLAIPALYLR
CCCCCCCCCCCCEECCCCCCCCCEEECCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHH
FALPMAFAMMLSGSYNLVDSYFILKYIGADALAGVTIAFPLQMMIFALACMIGNGTATLV
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
SRFLGANEFDKASQIANTGFALALCCGVIVTVVSLAQLDNLLAFIGVSSTLALAATEYLQ
HHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFISVLEMGVSGAAWA
HHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TVAGQCVSLFIAVVYFVPNNRFANKQALHKQAAQPICFRKEQIKLNLTEIKAILGLGSPI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHCCHHHHEEHHHHHHHHHHCCCHH
LLSYLGIACVISLVNHILVSHLANVVPNTPAANEVAYMISAYGLIGRFNIFIALPLMALT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLSVVTIIFMGFPTSVFGIFTDNHSLIA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCHHHHH
ACIKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLPQLSFT
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPQANRVSHGGNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCC
K
C
>Mature Secondary Structure
MKHATANTFKPASINVEPSDIVPFAATETSSHGKSHSGFQSRSQSTDSLGTLAIPALYLR
CCCCCCCCCCCCEECCCCCCCCCEEECCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHH
FALPMAFAMMLSGSYNLVDSYFILKYIGADALAGVTIAFPLQMMIFALACMIGNGTATLV
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
SRFLGANEFDKASQIANTGFALALCCGVIVTVVSLAQLDNLLAFIGVSSTLALAATEYLQ
HHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFISVLEMGVSGAAWA
HHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TVAGQCVSLFIAVVYFVPNNRFANKQALHKQAAQPICFRKEQIKLNLTEIKAILGLGSPI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHCCHHHHEEHHHHHHHHHHCCCHH
LLSYLGIACVISLVNHILVSHLANVVPNTPAANEVAYMISAYGLIGRFNIFIALPLMALT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLSVVTIIFMGFPTSVFGIFTDNHSLIA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCHHHHH
ACIKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLPQLSFT
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPQANRVSHGGNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA