Click here to switch to the map view.

The map label for this gene is degS [H]

Identifier: 160873851

GI number: 160873851

Start: 877694

End: 878776

Strand: Reverse

Name: degS [H]

Synonym: Sbal195_0729

Alternate gene names: 160873851

Gene position: 878776-877694 (Counterclockwise)

Preceding gene: 160873852

Following gene: 160873843

Centisome position: 16.43

GC content: 48.2

Gene sequence:

>1083_bases
ATGACGATAAAAGACACACTATTATATCTCGGTAAAGCCACCCTTTTCGGTCTTATCATGGCGGCCATGTTTTTATTGGT
AACCCGTTATTTCGATAACCAATCCCTCGGTAATAGCCTGCTACAAACCCGAGCCAACAACACAGTCGAGCTCTCCTTTG
CCAAGGCGGTCCGCCGCGCAGCCCCTGCGGTTGTTAACATTTATAGCCTCAGCATAGATCAGAACCGCCCACTTAACTCG
GGTTCGCTACAGGGCCTAGGTTCTGGGGTGATAATGAGCAAAGAAGGCTATATTCTTACGAATTATCATGTCATTAAAAA
GGCCGACGAAATTGTTGTCGCCCTGCAAGATGGACGCAAATTTACCTCTGAAGTGGTTGGCTTCGATCCAGAAACCGATT
TATCGGTACTCAAGATTGAAGGCGATAACTTACCGATTGTCCCCGTTAACCTCGACAGTCCGCCTCAAGTCGGTGATGTC
GTGCTCGCCATTGGTAATCCCTACAATTTAGGCCAAACCATTACCCAAGGCATCATAAGTGCCACGGGTCGTAACGGCTT
AAGTTCTGGTTACTTAGACTTTTTGCAAACCGATGCGGCGATTAATGCCGGTAACTCGGGCGGCGCACTCATTGACACTA
ACGGCAGCCTTATCGGTATTAATACCGCAGCATTCCAAGTGGGTGAAGAAGGCGGCGGCCATGGGATTAACTTCGCTATC
CCAATTAAATTGGCCCACAGCATTATGGGTAAGTTGATTAAGAATGGCCGCGTGATCCGTGGTGCTTTGGGGATTTCTGG
CGAGCCAATTAACCCTGTTGTGGCGCAGATCCTTAATCTACCCGACCTAAAAGGTGTGCTCGTTACAGGTGTCGATCCTA
ATGGCCCTGCGGCGCGTGCCCTCTTAATGCCAAGGGATGTAATTATTAAATACGATGGTGAAGATGTGCCAGGCGTTGAA
ATGCTGATGGACCGCATCGCTGAAACCACACCGGGTAAGAAAGTAATGATGACTGTGATACGCCAAGGTAAACAACAGGA
GTTACCTGTGATTATCGATGAAAAGGTTGTAGTCGATAACTAG

Upstream 100 bases:

>100_bases
ATTTTTTCTGCCACACATAAGCATAGGGAGCTTAGGTTCCCTATGCTTACATAGATTAAACATGTTAATCTAACTCACCT
TTTTCAAGATCCATCCTGCC

Downstream 100 bases:

>100_bases
AGTGACGCCCCTCATGCGTAGCACACTAAAACGCAGACAACAAAAAACCAGCTTTTAAGCTGGTTTTTTAATGGGTCGAG
ATTTTAATCTCTCAGGCCTA

Product: periplasmic serine protease DegS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNS
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARALLMPRDVIIKYDGEDVPGVE
MLMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN

Sequences:

>Translated_360_residues
MTIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNS
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARALLMPRDVIIKYDGEDVPGVE
MLMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN
>Mature_359_residues
TIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNSG
SLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDVV
LAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAIP
IKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARALLMPRDVIIKYDGEDVPGVEM
LMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=330, Percent_Identity=31.5151515151515, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4506141, Length=321, Percent_Identity=30.2180685358255, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI24308541, Length=286, Percent_Identity=32.1678321678322, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI7019477, Length=314, Percent_Identity=31.5286624203822, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789630, Length=353, Percent_Identity=49.5750708215297, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1789629, Length=274, Percent_Identity=43.0656934306569, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1786356, Length=263, Percent_Identity=42.2053231939163, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24646839, Length=286, Percent_Identity=31.1188811188811, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 38168; Mature: 38037

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHH
APAVVNIYSLSIDQNRPLNSGSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRK
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEHEEECCCEEEEEEECCCH
FTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDVVLAIGNPYNLGQTITQGIIS
HHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
ATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAI
HCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEHHEEEECCCCCCCCEEEEE
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARA
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHEE
LLMPRDVIIKYDGEDVPGVEMLMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN
EECCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEECCEEEECC
>Mature Secondary Structure 
TIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHH
APAVVNIYSLSIDQNRPLNSGSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRK
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEHEEECCCEEEEEEECCCH
FTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDVVLAIGNPYNLGQTITQGIIS
HHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
ATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAI
HCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEHHEEEECCCCCCCCEEEEE
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARA
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHEE
LLMPRDVIIKYDGEDVPGVEMLMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN
EECCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]