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The map label for this gene is clcR [H]

Identifier: 160873603

GI number: 160873603

Start: 551274

End: 552113

Strand: Direct

Name: clcR [H]

Synonym: Sbal195_0481

Alternate gene names: 160873603

Gene position: 551274-552113 (Clockwise)

Preceding gene: 160873597

Following gene: 160873607

Centisome position: 10.31

GC content: 48.93

Gene sequence:

>840_bases
ATGGTTGATTTACGTTTACTGCGTTTCTTTATCGCAATTTTTGAAGAGAACAATATCACCGCAGCGGCTAACCGTTGCTT
TGTGAGCCAGCCTTCACTGTCAGCTGGGTTAAAGCAATTGGAAGAAGAGTTAGGCGGCCAGCTATTTGAGCGTAGTAAGA
AAGGCGTTAAACCCTTAGATAGCGCGCACTATCTATACCCTTTGGCGGTTAAATTAGTCGAGGAGGCGAGTAAATTGCCG
GGTCTGTTTATGGCGAAGGCGAGCCGACAAAAGCTACGTTTGGCTGTGATGCCAGATCTCAGTCAGCGGCGTTTGGCGGG
ATTTTTACAGCAGGTGAATCAAGCCATTGAGAAGCTAGATCTGGAGCTGGTGGATTACCAAAGCCCCGCAGATTGTCGTT
TAACTATCGACAGTTTACGCCATGAAGATGAAGTGTTTTTCCCGCTATGGGAAGAGGATTATGTGCTGTGCGTCCCCAAG
GAGCATGCCCTCGCCCGAGTAGATAGCCTACGCCCCGAGCAGCTAAATGGTTTTGACTTTATCGAGTGTCCACCCTGTGA
AGCTCATCAGCAGACGATAGGTTTACTGGCGTGCAGCAATATGTCGCTCAATTTAGTCGCTAAGGCCGAATCTAAGTCTC
TCGTGATGTCGCTGGTGTTGGCTGGATTTGGGGTGAGTTTTTTACCCGATGGTTTAATTGAGGATGAGCCTAGGCTCAAG
CAAGTAAAATTTGATGGTCCGAGAATGTTTCGTCGTATTGGTCTGTGTTACCCGTCCCATCAGACGATTGCGCCAACGCT
GGCAGCCTTGTTACGGCATTTAGCCGCACGCGCGCATTAA

Upstream 100 bases:

>100_bases
TTTAGCCGAAAAATACTTATTCCAGCTGGATATGATAGTCTCAGCCTATGACACTATTATCGAACTTTGTACTTAATTTG
CCGTTGTCGGAGAAGATAAA

Downstream 100 bases:

>100_bases
TTCCAAGTTAGTTTTGGGTTATCAGTATTCAGATCAGTGAGTCGCTAAGGGCGATTCAGTGAGATTAAGCGGAGGCTCGA
CACCATAGGATTCAAATAGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: ClcABD operon transcriptional activator [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MVDLRLLRFFIAIFEENNITAAANRCFVSQPSLSAGLKQLEEELGGQLFERSKKGVKPLDSAHYLYPLAVKLVEEASKLP
GLFMAKASRQKLRLAVMPDLSQRRLAGFLQQVNQAIEKLDLELVDYQSPADCRLTIDSLRHEDEVFFPLWEEDYVLCVPK
EHALARVDSLRPEQLNGFDFIECPPCEAHQQTIGLLACSNMSLNLVAKAESKSLVMSLVLAGFGVSFLPDGLIEDEPRLK
QVKFDGPRMFRRIGLCYPSHQTIAPTLAALLRHLAARAH

Sequences:

>Translated_279_residues
MVDLRLLRFFIAIFEENNITAAANRCFVSQPSLSAGLKQLEEELGGQLFERSKKGVKPLDSAHYLYPLAVKLVEEASKLP
GLFMAKASRQKLRLAVMPDLSQRRLAGFLQQVNQAIEKLDLELVDYQSPADCRLTIDSLRHEDEVFFPLWEEDYVLCVPK
EHALARVDSLRPEQLNGFDFIECPPCEAHQQTIGLLACSNMSLNLVAKAESKSLVMSLVLAGFGVSFLPDGLIEDEPRLK
QVKFDGPRMFRRIGLCYPSHQTIAPTLAALLRHLAARAH
>Mature_279_residues
MVDLRLLRFFIAIFEENNITAAANRCFVSQPSLSAGLKQLEEELGGQLFERSKKGVKPLDSAHYLYPLAVKLVEEASKLP
GLFMAKASRQKLRLAVMPDLSQRRLAGFLQQVNQAIEKLDLELVDYQSPADCRLTIDSLRHEDEVFFPLWEEDYVLCVPK
EHALARVDSLRPEQLNGFDFIECPPCEAHQQTIGLLACSNMSLNLVAKAESKSLVMSLVLAGFGVSFLPDGLIEDEPRLK
QVKFDGPRMFRRIGLCYPSHQTIAPTLAALLRHLAARAH

Specific function: Involved in regulation of chlorinated catechol metabolism. Transcriptional activator of the clcABD chlorocatechol oxidative operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=245, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790399, Length=279, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI157672245, Length=261, Percent_Identity=25.6704980842912, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI145693105, Length=242, Percent_Identity=23.5537190082645, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31302; Mature: 31302

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50931 HTH_LYSR ; PS00697 DNA_LIGASE_A1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLRLLRFFIAIFEENNITAAANRCFVSQPSLSAGLKQLEEELGGQLFERSKKGVKPLD
CCHHHHHHHHHHHHCCCCEEHHHCEEECCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCC
SAHYLYPLAVKLVEEASKLPGLFMAKASRQKLRLAVMPDLSQRRLAGFLQQVNQAIEKLD
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHC
LELVDYQSPADCRLTIDSLRHEDEVFFPLWEEDYVLCVPKEHALARVDSLRPEQLNGFDF
CHHCCCCCCCCCEEEHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHCCCCCCCCCCCC
IECPPCEAHQQTIGLLACSNMSLNLVAKAESKSLVMSLVLAGFGVSFLPDGLIEDEPRLK
CCCCCCCHHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHCCHHHCCCCCCCCCCCHH
QVKFDGPRMFRRIGLCYPSHQTIAPTLAALLRHLAARAH
EEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVDLRLLRFFIAIFEENNITAAANRCFVSQPSLSAGLKQLEEELGGQLFERSKKGVKPLD
CCHHHHHHHHHHHHCCCCEEHHHCEEECCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCC
SAHYLYPLAVKLVEEASKLPGLFMAKASRQKLRLAVMPDLSQRRLAGFLQQVNQAIEKLD
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHC
LELVDYQSPADCRLTIDSLRHEDEVFFPLWEEDYVLCVPKEHALARVDSLRPEQLNGFDF
CHHCCCCCCCCCEEEHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHCCCCCCCCCCCC
IECPPCEAHQQTIGLLACSNMSLNLVAKAESKSLVMSLVLAGFGVSFLPDGLIEDEPRLK
CCCCCCCHHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHCCHHHCCCCCCCCCCCHH
QVKFDGPRMFRRIGLCYPSHQTIAPTLAALLRHLAARAH
EEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419291 [H]