Click here to switch to the map view.

The map label for this gene is rmlD [H]

Identifier: 160873576

GI number: 160873576

Start: 519873

End: 520787

Strand: Direct

Name: rmlD [H]

Synonym: Sbal195_0452

Alternate gene names: 160873576

Gene position: 519873-520787 (Clockwise)

Preceding gene: 160873574

Following gene: 160873577

Centisome position: 9.72

GC content: 52.24

Gene sequence:

>915_bases
ATGGCTAAGATCATGGTAACTGGCGCGACTGGGCTACTCGGCCGAGCTGTTGTAAAACAGCTCGAATTAACGGGACATGA
GGTTGTGGCCACAGGTTTTAGCCGCGCAAGTGAACGAGTGCATAAACTCGATCTGACCGCCCCTTTGGCTGTCGAAGCAT
TTATCGCCCGCGAGCAACCGCAAGTCATAGTGCACTGCGCCGCCGAGCGGCGCCCCGATGTGTCGGAGCAAAATCCGCAG
GCGGCATTGGCACTTAACTTAACTGCCAGCCAAGCCCTCGCTATGGCAGCCAAGGCCAATAACGCTTGGCTTATCTATAT
CTCCACCGACTATGTGTTCGATGGTACTCAGCCTAAGTACGCCGAAGATGCCGCCACTCATCCGGTTAATTTTTATGGTG
AATCTAAGTTAAAGGGCGAAGAAATAGTGCTTAACACGAGTGATGATTTTGCCGTGCTACGCTTGCCAATCCTTTACGGC
CAAGTCGAGAAGCTGAGTGAATCTGCTGTGCTAGTGCTGGTTAACCAATTGATTGAAAGTCGCGCTCAGGGTGTCGATCA
TTGGGCCGTGCGAAGTCCAACTTCAACCGCCGATATTGCCCAAGCCATAGATAAGATGATTGCACAGCATATTGAAGCAC
CTATCGTGCAGGGTATTTATCACTTTAGCGCCGCAGAGACCATGACCAAGTATCAGATGTTGCTGACCTTAGGGGAGATT
TTACAACTCAGTACGGCGCACTTAACGCCTGAGTCGACACCGACGGATAATGCCAAGCGGCCAAGGGACTGTAGCTTGAG
TTGTGCACGTTTAGCGGCGCTCGGTATTCGCTCCGATATTGATTTCGCCACTGGCGCACGCAAAGCATTAACGCAATCGA
GTGGCGCACTGGCCGCACTCGGACTCACACTGTAG

Upstream 100 bases:

>100_bases
CCTAAGTAAGTTTGGTTTAAAAGAGTAAACAAGTGCGTTGAATATGAAAAGCTTTTAGAATTGTCAGCCATACACATGAG
TTGAAACTGAATGGGGCAAT

Downstream 100 bases:

>100_bases
GAATGGCTATGGCTAAGATCTTAGGGACTAGTCTACAGGCCGCCGACCAAGTCGCATTACTGCGAACCTTAGGATTGCTG
CTGCAAATTGGCTTAACCAT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAKIMVTGATGLLGRAVVKQLELTGHEVVATGFSRASERVHKLDLTAPLAVEAFIAREQPQVIVHCAAERRPDVSEQNPQ
AALALNLTASQALAMAAKANNAWLIYISTDYVFDGTQPKYAEDAATHPVNFYGESKLKGEEIVLNTSDDFAVLRLPILYG
QVEKLSESAVLVLVNQLIESRAQGVDHWAVRSPTSTADIAQAIDKMIAQHIEAPIVQGIYHFSAAETMTKYQMLLTLGEI
LQLSTAHLTPESTPTDNAKRPRDCSLSCARLAALGIRSDIDFATGARKALTQSSGALAALGLTL

Sequences:

>Translated_304_residues
MAKIMVTGATGLLGRAVVKQLELTGHEVVATGFSRASERVHKLDLTAPLAVEAFIAREQPQVIVHCAAERRPDVSEQNPQ
AALALNLTASQALAMAAKANNAWLIYISTDYVFDGTQPKYAEDAATHPVNFYGESKLKGEEIVLNTSDDFAVLRLPILYG
QVEKLSESAVLVLVNQLIESRAQGVDHWAVRSPTSTADIAQAIDKMIAQHIEAPIVQGIYHFSAAETMTKYQMLLTLGEI
LQLSTAHLTPESTPTDNAKRPRDCSLSCARLAALGIRSDIDFATGARKALTQSSGALAALGLTL
>Mature_303_residues
AKIMVTGATGLLGRAVVKQLELTGHEVVATGFSRASERVHKLDLTAPLAVEAFIAREQPQVIVHCAAERRPDVSEQNPQA
ALALNLTASQALAMAAKANNAWLIYISTDYVFDGTQPKYAEDAATHPVNFYGESKLKGEEIVLNTSDDFAVLRLPILYGQ
VEKLSESAVLVLVNQLIESRAQGVDHWAVRSPTSTADIAQAIDKMIAQHIEAPIVQGIYHFSAAETMTKYQMLLTLGEIL
QLSTAHLTPESTPTDNAKRPRDCSLSCARLAALGIRSDIDFATGARKALTQSSGALAALGLTL

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=290, Percent_Identity=44.4827586206897, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519455, Length=290, Percent_Identity=44.4827586206897, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI1788352, Length=305, Percent_Identity=26.5573770491803, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32660; Mature: 32528

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIMVTGATGLLGRAVVKQLELTGHEVVATGFSRASERVHKLDLTAPLAVEAFIAREQP
CCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
QVIVHCAAERRPDVSEQNPQAALALNLTASQALAMAAKANNAWLIYISTDYVFDGTQPKY
CEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEEEEECEEECCCCCCC
AEDAATHPVNFYGESKLKGEEIVLNTSDDFAVLRLPILYGQVEKLSESAVLVLVNQLIES
CCCCCCCCEEECCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHH
RAQGVDHWAVRSPTSTADIAQAIDKMIAQHIEAPIVQGIYHFSAAETMTKYQMLLTLGEI
HHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQLSTAHLTPESTPTDNAKRPRDCSLSCARLAALGIRSDIDFATGARKALTQSSGALAAL
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCHHHHHHCCCCCEEEE
GLTL
CCCC
>Mature Secondary Structure 
AKIMVTGATGLLGRAVVKQLELTGHEVVATGFSRASERVHKLDLTAPLAVEAFIAREQP
CEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
QVIVHCAAERRPDVSEQNPQAALALNLTASQALAMAAKANNAWLIYISTDYVFDGTQPKY
CEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEEEEECEEECCCCCCC
AEDAATHPVNFYGESKLKGEEIVLNTSDDFAVLRLPILYGQVEKLSESAVLVLVNQLIES
CCCCCCCCEEECCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHH
RAQGVDHWAVRSPTSTADIAQAIDKMIAQHIEAPIVQGIYHFSAAETMTKYQMLLTLGEI
HHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQLSTAHLTPESTPTDNAKRPRDCSLSCARLAALGIRSDIDFATGARKALTQSSGALAAL
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCHHHHHHCCCCCEEEE
GLTL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA