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The map label for this gene is murC

Identifier: 160873539

GI number: 160873539

Start: 471661

End: 473127

Strand: Direct

Name: murC

Synonym: Sbal195_0414

Alternate gene names: 160873539

Gene position: 471661-473127 (Clockwise)

Preceding gene: 160873538

Following gene: 160873540

Centisome position: 8.82

GC content: 52.01

Gene sequence:

>1467_bases
ATGACTAAGACAGAAAGATACGCACAACTGAGAAGCATGATCCCAGAAATGCGCCGTATTAAGCGTATTCACTTCGTCGG
CATTGGCGGCGCGGGCATGGGCGGGATCGCCGAAGTGTTAGTGAACGAAGGCTATCAGGTGAGTGGTTCGGATATCGCGC
AAAATGCCGTGACCGACAGATTGTGTTTGCTCGGTGCCAAGATCCAAATTGGTCATGCCGCCGAAAACGTGCAGCAAGTG
GATGTGGTCGTGGTCTCCACGGCGATTAATCTGGAAAACCCAGAAATCCTTGCCGCTAAAGAATTACGTATTCCTATTGT
GCGCCGCGCCGAAATGCTAGCCGAGTTGATGCGTTATCGACATGGTGTGGCAATTGCGGGCACCCATGGTAAAACCACGA
CAACGAGCCTTATCGCCAGCGTGTACGGTCAAGCAGGGCGGGATCCAACCTTCGTGATTGGTGGCTTGCTCAATAGCGCC
GGTACCAACGCCAGATTAGGCACCAGCCGTTACTTGATTGCCGAAGCCGATGAGAGTGATGCGAGCTTCCTGCATTTGCA
GCCTATGGTCAGTGTGGTGACTAACATTGAAGCCGATCACATGGATACCTATGGCGGTGATTTCGAGAAATTGAAATCGA
CCTTCGTGGATTTCCTACATAACTTGCCGTTTTACGGTGTCGCAGTTGTGTGTATCGACGATGCTGTGGTGCGTGAAATC
ATGCCGCGGATTGGTCGTCAACTCGTGACCTATGGTTTTAGTGACGATGCGGACGTGCAAGCGCTGAATTTCAGTCAGCA
AGGGCATCAGTGTCGTTTCACGGTGAGACGTAAAGGCAAAGCGGATCTCGATCTGGTGCTTAACTTGCCGGGTCAACATA
ACGTGCTTAATGCCTTAGCTGCGATAGCGGTCGCGACCGAAGATGAAATCGACGACAGCGCCATTACTCAGGCGTTAGTG
GAGTTCCAAGGTATAGGTCGTCGTTTCCAGCATTTGGGCAAGTTTGCTACGCCCAAGGGCGAAGTTATGTTGGTCGATGA
TTATGGCCATCACCCCAGTGAAGTTGCCGCGACCATTAAAGCTGCCCGTGCAGGTTGGCCCGACAAGCGTCTGGTTATGG
CGTATCAGCCACACAGATACACCCGTACCCGTGATTTGTATGAAGACTTTGTTGAAGTGTTATCCCAAGTGGATTGTTTA
CTGTTGCTCGATGTTTATAGTGCGGGTGAAGCGCCGATCACTGGTGCCGATGGCCGAGCCTTATGTCGCTCAATTCGCCT
GCGTGGCCAGTTAGATCCGATCTTTATCGCCAGTCCTGATCAGCTCGCAGAGGTATTGCCCGATGTATTGCAAGAGGGGG
ATTTATTACTCACCCAAGGTGCGGGTAATATTGGCGCCCTGTCGCGATTGTTAGCGACGACAGAATTGGGCTTTGCCGTT
GCGGAATTACCTGCGCAAGCAAGCTGA

Upstream 100 bases:

>100_bases
AATTAGCCCGTATGGGCCAAAGAGCGAGAGACGTTGCCGTACTGGATGCGACTGAACAAGTTGCCGCAGTGTGCATCAGC
CTTGCCGAGAAAGGATAAGC

Downstream 100 bases:

>100_bases
TCTTTAGCGCTTGATCTGCGAGGAAAAGGAAATTTTGACCAAAGGATTTTGGTCTATATAATGGCCGGTTTTCTGTGGTT
TTTAATGAGTGTCGTTAAAG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTKTERYAQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNAVTDRLCLLGAKIQIGHAAENVQQV
DVVVVSTAINLENPEILAAKELRIPIVRRAEMLAELMRYRHGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSA
GTNARLGTSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDAVVREI
MPRIGRQLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKADLDLVLNLPGQHNVLNALAAIAVATEDEIDDSAITQALV
EFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIKAARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDCL
LLLDVYSAGEAPITGADGRALCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRLLATTELGFAV
AELPAQAS

Sequences:

>Translated_488_residues
MTKTERYAQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNAVTDRLCLLGAKIQIGHAAENVQQV
DVVVVSTAINLENPEILAAKELRIPIVRRAEMLAELMRYRHGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSA
GTNARLGTSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDAVVREI
MPRIGRQLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKADLDLVLNLPGQHNVLNALAAIAVATEDEIDDSAITQALV
EFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIKAARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDCL
LLLDVYSAGEAPITGADGRALCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRLLATTELGFAV
AELPAQAS
>Mature_487_residues
TKTERYAQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNAVTDRLCLLGAKIQIGHAAENVQQVD
VVVVSTAINLENPEILAAKELRIPIVRRAEMLAELMRYRHGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSAG
TNARLGTSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDAVVREIM
PRIGRQLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKADLDLVLNLPGQHNVLNALAAIAVATEDEIDDSAITQALVE
FQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIKAARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDCLL
LLDVYSAGEAPITGADGRALCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRLLATTELGFAVA
ELPAQAS

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=479, Percent_Identity=65.7620041753653, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=27.5268817204301, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SHEB2 (B8E699)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002356385.1
- ProteinModelPortal:   B8E699
- SMR:   B8E699
- GeneID:   7089566
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_0428
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52973; Mature: 52842

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTERYAQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNAVTDR
CCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHCCCCEECCCHHHHHHHHHH
LCLLGAKIQIGHAAENVQQVDVVVVSTAINLENPEILAAKELRIPIVRRAEMLAELMRYR
HHHHCCEEEECHHHCCHHHEEEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
HGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSAGTNARLGTSRYLIAEADESD
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCCCCCEEEEEECCCCC
ASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDAVVREI
CCEEEHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEEECHHHHHHH
MPRIGRQLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKADLDLVLNLPGQHNVLNALA
HHHHHHHHEECCCCCCCCEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHH
AIAVATEDEIDDSAITQALVEFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIK
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHH
AARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDCLLLLDVYSAGEAPITGADGRA
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCHHH
LCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRLLATTELGFAV
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
AELPAQAS
HHCCCCCC
>Mature Secondary Structure 
TKTERYAQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNAVTDR
CCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHCCCCEECCCHHHHHHHHHH
LCLLGAKIQIGHAAENVQQVDVVVVSTAINLENPEILAAKELRIPIVRRAEMLAELMRYR
HHHHCCEEEECHHHCCHHHEEEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
HGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSAGTNARLGTSRYLIAEADESD
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCCCCCEEEEEECCCCC
ASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDAVVREI
CCEEEHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEEECHHHHHHH
MPRIGRQLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKADLDLVLNLPGQHNVLNALA
HHHHHHHHEECCCCCCCCEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHH
AIAVATEDEIDDSAITQALVEFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIK
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHH
AARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDCLLLLDVYSAGEAPITGADGRA
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCHHH
LCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRLLATTELGFAV
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
AELPAQAS
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA