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The map label for this gene is ftsI [H]

Identifier: 160873532

GI number: 160873532

Start: 462331

End: 464085

Strand: Direct

Name: ftsI [H]

Synonym: Sbal195_0407

Alternate gene names: 160873532

Gene position: 462331-464085 (Clockwise)

Preceding gene: 160873531

Following gene: 160873533

Centisome position: 8.65

GC content: 51.17

Gene sequence:

>1755_bases
ATGACTAGGCAAGCGAAAATCAAACGGGTAAGCAAACCGCAGAAACCACAACTAATCCATTGGCGTTTATACGTAGTGGT
GGGGTTTGTGTGTACGCTATTTTGCAGCCTAGTGGGACGCGCAGCCTACATTCAAATTATCGAACCTGACAAATTACGCC
ATGAAAGCGATATGCGTACCTTACGGACCACGAGCCGTGAGGTGCAGCGTGGCTTGATCACCGATCGCAATGGCGACATG
TTGGCCGTCAGTGTGCCAGTGCGTGCCGTTTGGGCCGATCCTAAACAAGTTAACGATAACAATGGCTTTGCGGATATGCG
CCGCTGGCAAGCTTTAGCTGATGTGTTGCATGAACCCGTAGAAGACATATTAGATCGGGTGCGCAGTAATCCCACCAAAC
GCTTTACCTACTTGAAACGCCAAATTACCCCTGCGGTCGCGGACTACATCACTCAGCTGAAATTACCCGGTGTTTTCCTC
AAATCTGAATCCCGCCGCTATTACCCTGGTGGTGAAATCACTGCTCAGCTTATCGGTATCACTAATATTGATGATGTTGG
AATTGAAGGCGTAGAAAATGCTTATAACAGCTGGCTAACGGGCACGCCTTCAAAACAGAAAGTGCGTAAATCCCGTGATG
GTCATGTGGTTGAGCGTCTCGATATTATCCAAGAAGGCGAAAGCCCGAATGATCTTGTGCTCAGCATAGATCAACGGATT
CAGCAGTTAGCGTACCGCGAGCTGAAACGCACCACAGAGATGAACCAAGCGACCTCAGGTTCCATCGTCGTACTCGATAT
TCACACTGGTGAAGTCTTGGCGATGGTAAATACACCTTCGTACAACCCTAATGCGCGCGATAATCTGCAAACCTTCAGAA
TGCGTAACCGCGCCATGACGGATACTTTCGAGCCAGGTTCGACCATTAAGCCCTTTGTAGTGGCTGCGGCGCTTGAAGCG
GGCACAGTCAAATCGACTGACATTATTGCCACTTCACCGGGTTGGATGCGTTTAGGCGGCCGCCAAGTGCGCGACCCTGC
CAACTACGGCGACATGAGTTTGGCGCGTATTCTGGCGAAATCCAGTAACGTCGGCATCAGTAAATTGGCCTTGTCTATTC
CGGTGCAGCAGTTACTCGGCACCTATCAATCTATGGGACTTGGGAGTTTCTCAGGGATCAACCTTACGGGTGAAAGCGCG
GGGGTTATTCAAGACCGCCACCGTTGGTCTGACTTTGAGCGCGCCACCTTGTCCTTCGGTTACGGTTTAACGGCAACCAC
ACTGCAACTTGCGCGCATGTATGCCACTTTAGGCAATGGCGGCACCTTATTCCCCGTCTCAATCATGAAACTGAAAAAGC
CCCCCGTCGGTGAGCGAGTTATTTCTGAAGATGTGGCCCACGATGTGATGCAAATGCTGGTCGGCGTGACAGAAAAAGGC
GGCACCGGCACCTTGGCGCATATTGACGGTTATCCGGTTGCAGGCAAGTCGGGCACCAGTCGTAAGGCGGTTGCTGGCGG
TTATGGTGATGATTATGTTGCTTTATTTGCAGGTGTTGCACCGGCGAATAATCCTAAGTTAGCGATAGTGGTGGTCGTGA
ACGAGCCTAAGGGCGATCTCTATTATGGTGGTTCAGTGGCGGGGCCGGCATTTGCCAAAGTCATGTCTGGCGCACTGCAA
ATGTTAAACGTTGAACCCATTACCGATAAAGAACAAGTGCAATTGGCGGGTATCGCCGCCGGGAGAGCTGAATGA

Upstream 100 bases:

>100_bases
CACAGTCGTATTACGCGCATTGCCTCTAAGGAACTCAACATGAGTCGTCCGTTACCCAGCGAAGAAGTTGTGGTAAAGGT
GCCGTGAGTATAGGGAAGAT

Downstream 100 bases:

>100_bases
TGTTATTACGGGATCTGCTCGCGCCTTGGCTGCATTATGCCGGCGCGCAGTCCTTCAGCGATTTGACCTTAGATAGCCGC
GCAATACGTCGCGGCGATGT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MTRQAKIKRVSKPQKPQLIHWRLYVVVGFVCTLFCSLVGRAAYIQIIEPDKLRHESDMRTLRTTSREVQRGLITDRNGDM
LAVSVPVRAVWADPKQVNDNNGFADMRRWQALADVLHEPVEDILDRVRSNPTKRFTYLKRQITPAVADYITQLKLPGVFL
KSESRRYYPGGEITAQLIGITNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVERLDIIQEGESPNDLVLSIDQRI
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNARDNLQTFRMRNRAMTDTFEPGSTIKPFVVAAALEA
GTVKSTDIIATSPGWMRLGGRQVRDPANYGDMSLARILAKSSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESA
GVIQDRHRWSDFERATLSFGYGLTATTLQLARMYATLGNGGTLFPVSIMKLKKPPVGERVISEDVAHDVMQMLVGVTEKG
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDLYYGGSVAGPAFAKVMSGALQ
MLNVEPITDKEQVQLAGIAAGRAE

Sequences:

>Translated_584_residues
MTRQAKIKRVSKPQKPQLIHWRLYVVVGFVCTLFCSLVGRAAYIQIIEPDKLRHESDMRTLRTTSREVQRGLITDRNGDM
LAVSVPVRAVWADPKQVNDNNGFADMRRWQALADVLHEPVEDILDRVRSNPTKRFTYLKRQITPAVADYITQLKLPGVFL
KSESRRYYPGGEITAQLIGITNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVERLDIIQEGESPNDLVLSIDQRI
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNARDNLQTFRMRNRAMTDTFEPGSTIKPFVVAAALEA
GTVKSTDIIATSPGWMRLGGRQVRDPANYGDMSLARILAKSSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESA
GVIQDRHRWSDFERATLSFGYGLTATTLQLARMYATLGNGGTLFPVSIMKLKKPPVGERVISEDVAHDVMQMLVGVTEKG
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDLYYGGSVAGPAFAKVMSGALQ
MLNVEPITDKEQVQLAGIAAGRAE
>Mature_583_residues
TRQAKIKRVSKPQKPQLIHWRLYVVVGFVCTLFCSLVGRAAYIQIIEPDKLRHESDMRTLRTTSREVQRGLITDRNGDML
AVSVPVRAVWADPKQVNDNNGFADMRRWQALADVLHEPVEDILDRVRSNPTKRFTYLKRQITPAVADYITQLKLPGVFLK
SESRRYYPGGEITAQLIGITNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVERLDIIQEGESPNDLVLSIDQRIQ
QLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNARDNLQTFRMRNRAMTDTFEPGSTIKPFVVAAALEAG
TVKSTDIIATSPGWMRLGGRQVRDPANYGDMSLARILAKSSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESAG
VIQDRHRWSDFERATLSFGYGLTATTLQLARMYATLGNGGTLFPVSIMKLKKPPVGERVISEDVAHDVMQMLVGVTEKGG
TGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDLYYGGSVAGPAFAKVMSGALQM
LNVEPITDKEQVQLAGIAAGRAE

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=568, Percent_Identity=48.0633802816901, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1786854, Length=620, Percent_Identity=26.2903225806452, Blast_Score=139, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63762; Mature: 63631

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQAKIKRVSKPQKPQLIHWRLYVVVGFVCTLFCSLVGRAAYIQIIEPDKLRHESDMRT
CCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHCCHHHHHH
LRTTSREVQRGLITDRNGDMLAVSVPVRAVWADPKQVNDNNGFADMRRWQALADVLHEPV
HHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EDILDRVRSNPTKRFTYLKRQITPAVADYITQLKLPGVFLKSESRRYYPGGEITAQLIGI
HHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEEE
TNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVERLDIIQEGESPNDLVLSIDQRI
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEHHHHH
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNARDNLQTFRMRNRAMT
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCC
DTFEPGSTIKPFVVAAALEAGTVKSTDIIATSPGWMRLGGRQVRDPANYGDMSLARILAK
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHH
SSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESAGVIQDRHRWSDFERATLSFG
CCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHCCHHHHHHHHCC
YGLTATTLQLARMYATLGNGGTLFPVSIMKLKKPPVGERVISEDVAHDVMQMLVGVTEKG
CCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDL
CCEEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCE
YYGGSVAGPAFAKVMSGALQMLNVEPITDKEQVQLAGIAAGRAE
EECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHEEEEEECCCCCC
>Mature Secondary Structure 
TRQAKIKRVSKPQKPQLIHWRLYVVVGFVCTLFCSLVGRAAYIQIIEPDKLRHESDMRT
CCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHCCHHHHHH
LRTTSREVQRGLITDRNGDMLAVSVPVRAVWADPKQVNDNNGFADMRRWQALADVLHEPV
HHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EDILDRVRSNPTKRFTYLKRQITPAVADYITQLKLPGVFLKSESRRYYPGGEITAQLIGI
HHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEEE
TNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVERLDIIQEGESPNDLVLSIDQRI
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEHHHHH
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNARDNLQTFRMRNRAMT
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCC
DTFEPGSTIKPFVVAAALEAGTVKSTDIIATSPGWMRLGGRQVRDPANYGDMSLARILAK
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHH
SSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESAGVIQDRHRWSDFERATLSFG
CCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHCCHHHHHHHHCC
YGLTATTLQLARMYATLGNGGTLFPVSIMKLKKPPVGERVISEDVAHDVMQMLVGVTEKG
CCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDL
CCEEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCE
YYGGSVAGPAFAKVMSGALQMLNVEPITDKEQVQLAGIAAGRAE
EECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]