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The map label for this gene is gmk [H]

Identifier: 160873485

GI number: 160873485

Start: 408191

End: 408823

Strand: Reverse

Name: gmk [H]

Synonym: Sbal195_0360

Alternate gene names: 160873485

Gene position: 408823-408191 (Counterclockwise)

Preceding gene: 160873490

Following gene: 160873484

Centisome position: 7.65

GC content: 49.45

Gene sequence:

>633_bases
ATGACCGCACGCGGAAATTTATTTATTGTGTCGGCGCCAAGTGGCGCAGGTAAATCCTCGCTGATCTCGGCCTTGCTTAA
AGACAAGCCCGCTGACATGCAGGTTTCGGTATCACATACCACCCGCGCGCCACGCCCAGGTGAAGTCGATGGTCAACACT
ATCACTTCGTTAATGTTGAACAATTCAAAGCGTTAATTGCTGAAAATGCCTTTTTTGAATGGGCAGAAGTGTTCGGCAAT
TACTATGGTACCTCGCGCCATGTGATTGAGCATACGCTCACCCAAGGTATCGATGTTTTCCTCGATATCGACTGGCAAGG
TGCCGAGCAAGTTAAAGCTGTGATGCCCGATGCCGTTGGTGTGTTTATTCTGCCACCCTCGAAAGCCGAGCTAGAACGCC
GCCTCACTGGCCGTGGACAAGACAGTAGCGATGTGATCGCCAGCCGTATGGCACAAGCCGTATCGGAAATGTCCCACTAT
AAAGAATATGATTTTATTATCGTCAACGACGATTTTGACACTGCGTTAGCTGATTTGCGTGCCATCATTCGCAGTCAGCG
CTTAACCTGTGCTAGTCAGATCCACGCGCAAAATGATATGCTTAACGATCTGTTGGCAGGCCAACTGTCATAG

Upstream 100 bases:

>100_bases
AAATTGCTGGCCTACAAGCCCTAGTATTTCTATGGTCAAAATCGGTATAATGCTCGGCTTTCTGGGCCCTTCTTGCGTTA
ACCAATTGGATATTTAGCTC

Downstream 100 bases:

>100_bases
TGTACAATTTTGCGTCATTTTTTCCCTAGATAAACTGGAGTTTCAACACATGGCTCGCGTAACTGTAGAAGACGCCGTAG
AACAAATCGGCAACCGTTTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTARGNLFIVSAPSGAGKSSLISALLKDKPADMQVSVSHTTRAPRPGEVDGQHYHFVNVEQFKALIAENAFFEWAEVFGN
YYGTSRHVIEHTLTQGIDVFLDIDWQGAEQVKAVMPDAVGVFILPPSKAELERRLTGRGQDSSDVIASRMAQAVSEMSHY
KEYDFIIVNDDFDTALADLRAIIRSQRLTCASQIHAQNDMLNDLLAGQLS

Sequences:

>Translated_210_residues
MTARGNLFIVSAPSGAGKSSLISALLKDKPADMQVSVSHTTRAPRPGEVDGQHYHFVNVEQFKALIAENAFFEWAEVFGN
YYGTSRHVIEHTLTQGIDVFLDIDWQGAEQVKAVMPDAVGVFILPPSKAELERRLTGRGQDSSDVIASRMAQAVSEMSHY
KEYDFIIVNDDFDTALADLRAIIRSQRLTCASQIHAQNDMLNDLLAGQLS
>Mature_209_residues
TARGNLFIVSAPSGAGKSSLISALLKDKPADMQVSVSHTTRAPRPGEVDGQHYHFVNVEQFKALIAENAFFEWAEVFGNY
YGTSRHVIEHTLTQGIDVFLDIDWQGAEQVKAVMPDAVGVFILPPSKAELERRLTGRGQDSSDVIASRMAQAVSEMSHYK
EYDFIIVNDDFDTALADLRAIIRSQRLTCASQIHAQNDMLNDLLAGQLS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=39.4285714285714, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=39.4285714285714, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=39.4285714285714, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI262118255, Length=177, Percent_Identity=30.5084745762712, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4505237, Length=177, Percent_Identity=30.5084745762712, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI262118259, Length=177, Percent_Identity=30.5084745762712, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI262118263, Length=177, Percent_Identity=30.5084745762712, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=29.8913043478261, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=26.8041237113402, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI21361598, Length=195, Percent_Identity=28.7179487179487, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI111154074, Length=165, Percent_Identity=30.9090909090909, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21536464, Length=189, Percent_Identity=25.3968253968254, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI119943108, Length=176, Percent_Identity=27.8409090909091, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI261862237, Length=176, Percent_Identity=27.8409090909091, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI119943106, Length=176, Percent_Identity=27.8409090909091, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=205, Percent_Identity=66.8292682926829, Blast_Score=289, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=35, Blast_Score=126, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=35, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71988041, Length=187, Percent_Identity=28.8770053475936, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71988048, Length=187, Percent_Identity=29.9465240641711, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71984092, Length=157, Percent_Identity=29.9363057324841, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557440, Length=179, Percent_Identity=25.1396648044693, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=41.2087912087912, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21356141, Length=187, Percent_Identity=38.5026737967914, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45554481, Length=202, Percent_Identity=28.7128712871287, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007136, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI85724806, Length=202, Percent_Identity=28.7128712871287, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554489, Length=202, Percent_Identity=28.7128712871287, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640542, Length=202, Percent_Identity=28.7128712871287, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077626, Length=202, Percent_Identity=28.7128712871287, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23169; Mature: 23038

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARGNLFIVSAPSGAGKSSLISALLKDKPADMQVSVSHTTRAPRPGEVDGQHYHFVNVE
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEECHH
QFKALIAENAFFEWAEVFGNYYGTSRHVIEHTLTQGIDVFLDIDWQGAEQVKAVMPDAVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCE
VFILPPSKAELERRLTGRGQDSSDVIASRMAQAVSEMSHYKEYDFIIVNDDFDTALADLR
EEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
AIIRSQRLTCASQIHAQNDMLNDLLAGQLS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TARGNLFIVSAPSGAGKSSLISALLKDKPADMQVSVSHTTRAPRPGEVDGQHYHFVNVE
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEECHH
QFKALIAENAFFEWAEVFGNYYGTSRHVIEHTLTQGIDVFLDIDWQGAEQVKAVMPDAVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCE
VFILPPSKAELERRLTGRGQDSSDVIASRMAQAVSEMSHYKEYDFIIVNDDFDTALADLR
EEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
AIIRSQRLTCASQIHAQNDMLNDLLAGQLS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]