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The map label for this gene is copS [H]

Identifier: 160873421

GI number: 160873421

Start: 334491

End: 335747

Strand: Direct

Name: copS [H]

Synonym: Sbal195_0295

Alternate gene names: 160873421

Gene position: 334491-335747 (Clockwise)

Preceding gene: 160873420

Following gene: 160873422

Centisome position: 6.26

GC content: 49.01

Gene sequence:

>1257_bases
GTGACTGTGATCATTGGGGCGCTGCTATTTGCCCTCTATCGACAGTTGATCATCGAGCAACAGTATCAAGTGACTCAATA
TTTAGAGTCAGAGACACAACGTTATCAGCAACTTGCCCTAACGGTTGACCGCCGTAGTTTTGCCGCTCAAATCCGCGCCG
CCGATCCACAAACCGCTCTGATCGCTTGGCGTAATAGCTACGATATGGTTGGTGCCTTGAGCTTTATGCCCGAAGGCATG
CCCATGCTACCGCAAACGCGGGATTTCCCCATCTTAACCGGTGGCCCAGATAAGCTGCATATTCTTACCGGCGGGCTGGT
GATGACCCGCTACGGCCCAGTGTTGATTGCGACCCGTACCGATAACTTAGCGACGTTAATTGATAAGTTTATCAGCGCTG
CGGCGACAGCCGTGATGCTTACGATAGTGTTGACCTTAGCGCTCGGCTATCTATTTTCTAAGGCGATTTTACGTCGATTA
GTGCAATACAACCGCTTGAGTGAACAGATTGAACGCGGCCACTATGACACCCGCTTGCCCTTGAGTTGGCGTCAGGATGA
GTTTGATATGTTGGCGCTACAGTTTAATAATGTGCTGGATATCCTCGAAAATAACCTGATGGCAGTGCGCGGCGCGACCG
ATAATATCGCCCATGATTTACGTACTCCACTGTCGCATATCCGCATCGGCCTTGAAGAGTTGGCGAGTAAACCCAGCGAT
GAGATTAGCGAGGGTTGCGCCATTTTGACCGAGGAGCTCGACCATTGTTTAGCGACATTTGATGCCATGTTGTCACTCAC
GCGTATCGAAGAAGGTCAGCAGACGCTCGATTTGCAGGAGTTAAGCCTAGCGCAACTATGTACCGATTTGTTGGACATGG
CCGATGCCGTGGCAGAATCCAATGAGCAAACCTTGAGTTTGTCGCTGTTGGCTGACCATAAGGTATTTGGTGATAAATAC
TTATTATTCCAAGCTTTATATAATCTCGTCGATAACGCGATGAAGTATTCTGGCCAAGGTGCGCGGATTGAAATTATCCA
ATCAGGCCCGCAAATTCAGATCCGCGATAATGGCCCAGGTATTCCCGACGACAGTAAAGAAAGAGTGTTCGAACGCTTAG
TGCGCCTCGACCCCAGCCGGCATTTACAGGGTACAGGTTTAGGATTATCTATGGTCAAAGCGATTCTCTCACGGCACAAT
GCCAAAATTAATCTCACGGATAATCATCCCGGCTTAGTGGTCACTATTAAGTTTTAA

Upstream 100 bases:

>100_bases
CTTATCGAAACCGTGAGGGGAGCGGGTTATCGCTTACGACAAAGGCATTAAGCCTTACCAAAGCAGCGCCTGGCGCATCA
CAATCGTCTTTTCGACCTTA

Downstream 100 bases:

>100_bases
GTCGATGATCCGCATTACAGCGTCGAGAACTCCATGTATCGAATCATAGCCGATGAGGCTGACTTCCTTGTTATCTCCAA
ATCAGCCAAAGTGCATTTTC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTVIIGALLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGM
PMLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRL
VQYNRLSEQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGATDNIAHDLRTPLSHIRIGLEELASKPSD
EISEGCAILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLADHKVFGDKY
LLFQALYNLVDNAMKYSGQGARIEIIQSGPQIQIRDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAILSRHN
AKINLTDNHPGLVVTIKF

Sequences:

>Translated_418_residues
MTVIIGALLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGM
PMLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRL
VQYNRLSEQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGATDNIAHDLRTPLSHIRIGLEELASKPSD
EISEGCAILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLADHKVFGDKY
LLFQALYNLVDNAMKYSGQGARIEIIQSGPQIQIRDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAILSRHN
AKINLTDNHPGLVVTIKF
>Mature_417_residues
TVIIGALLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGMP
MLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLV
QYNRLSEQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGATDNIAHDLRTPLSHIRIGLEELASKPSDE
ISEGCAILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLADHKVFGDKYL
LFQALYNLVDNAMKYSGQGARIEIIQSGPQIQIRDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAILSRHNA
KINLTDNHPGLVVTIKF

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cyto

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=331, Percent_Identity=25.6797583081571, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788279, Length=283, Percent_Identity=27.5618374558304, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787894, Length=267, Percent_Identity=28.8389513108614, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788393, Length=263, Percent_Identity=28.8973384030418, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786600, Length=206, Percent_Identity=28.1553398058252, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=30.0724637681159, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=28.6324786324786, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=27.208480565371, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=204, Percent_Identity=28.921568627451, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=202, Percent_Identity=26.2376237623762, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790861, Length=292, Percent_Identity=24.6575342465753, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=241, Percent_Identity=24.4813278008299, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=206, Percent_Identity=27.6699029126214, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=210, Percent_Identity=26.6666666666667, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=220, Percent_Identity=25.4545454545455, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46727; Mature: 46595

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIIGALLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IAWRNSYDMVGALSFMPEGMPMLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRT
EEECCCCCHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECCEEEECCCCEEEEECC
DNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLSEQIERGHYDTRLP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LSWRQDEFDMLALQFNNVLDILENNLMAVRGATDNIAHDLRTPLSHIRIGLEELASKPSD
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCCH
EISEGCAILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NEQTLSLSLLADHKVFGDKYLLFQALYNLVDNAMKYSGQGARIEIIQSGPQIQIRDNGPG
CCCEEEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCC
IPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAILSRHNAKINLTDNHPGLVVTIKF
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEEC
>Mature Secondary Structure 
TVIIGALLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IAWRNSYDMVGALSFMPEGMPMLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRT
EEECCCCCHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECCEEEECCCCEEEEECC
DNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLSEQIERGHYDTRLP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LSWRQDEFDMLALQFNNVLDILENNLMAVRGATDNIAHDLRTPLSHIRIGLEELASKPSD
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCCH
EISEGCAILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NEQTLSLSLLADHKVFGDKYLLFQALYNLVDNAMKYSGQGARIEIIQSGPQIQIRDNGPG
CCCEEEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCC
IPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAILSRHNAKINLTDNHPGLVVTIKF
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8449873 [H]