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The map label for this gene is moeA [H]

Identifier: 160873262

GI number: 160873262

Start: 157645

End: 158898

Strand: Reverse

Name: moeA [H]

Synonym: Sbal195_0136

Alternate gene names: 160873262

Gene position: 158898-157645 (Counterclockwise)

Preceding gene: 160873264

Following gene: 160873261

Centisome position: 2.97

GC content: 51.59

Gene sequence:

>1254_bases
ATGTCCGTAAAAGCCGATCCTTGTTCGCAACCTAGCTTAATGCATCCAGATCAAGCTATTCCCCTTTTGCTCGAACAAGT
TAGCCCAGTGTCAGACACCGAAGTCGTATTGCTTCCCCATGCCCTTGGCCGCGTCCTTGCCGAAGATCTCGCTTCCTGCA
TCGACCTGCCTCCCTTCGACAACTCCTCAATGGACGGTTACGCCTTCCGTTTTGTCGACTTGAATACACAAACCAATCGC
ACCTCATTACGCCTCATCGGCACTTCGTTCGCCGGCCATGGTTTTGAAGGTGAAGCCAAACCTAATACCTGCATACGGAT
CATGACGGGCGCGCCCGTGCCTGCGGGTTATGACACAGTACAAATGCAGGAAGAAGCCGAAGTTGAAGGTGAGATTATTC
ACATTCGCCATCCTAAGGCGCAAGGTGCCAATGTGCGTTGCCGTGGTGAAGAACTGACCCAAGGCACTAAAGTACTTACT
GCTGGTATTCAAATTGGCGCCGCCGAACTCGGCGTATTGGCCACTATTGGTATCAGCCAAGTGCGAGTCTATCGTCAACT
TAAGGTGGCGTTTTTCTCCACGGGTGACGAACTGCGTCCTGTTGGCAGCGAACTCGCGCCAGGGCAAATTTACGATTCAA
ACCGTTACTCGATTCAAGGTTTACTCAGCCGCGCTAATGTTGAATGGCTCGATTTAGGCGTAATAGCCGATGATCCTGAA
GCCATACGTCAGGCATTTCGCCAAGCCGCCAGCCAAGCAGATATGGTGCTGACCTCGGGCGGCGTGTCGGTCGGCGAAGC
TGACTTTACGAAGCAAATTCTCGATGAAGAAGGCAAAATCACCTTCTGGAAACTCGCCATCAAACCTGGTAAGCCCTTCG
CCATGGGCAAAATTGGCAAGGCAGTATTCTGTGGTTTACCGGGGAACCCCGTGTCTTCTATGGTGACATTTTACAAGCTG
GTTTGGCCAATACTGAACAAGATGCAGGGTTTAACCCCAGTTGCACCTTTGATGTTAGACGCCACACTCACCACGCCGGT
GCGTAAACAACCGGGCCGCGTCGAATATCAACGGGGCATTTTAAGCCGTAATGCACAAGGTAAACTCGAGGTTGACATTA
CTGGTAGCCAAGGTTCAGGTATGTTGACCTCAATGAGCCTAGCGAACTGTTTCGTTTTATTGGAACAATTCCAAGGGGAT
ACTGCCGCTGGCACGCAAGTGACGGTCGAGCCCTTTAACAGCGTGCTCTGCTAG

Upstream 100 bases:

>100_bases
ATCATAGCCATCGTCGATCACCGTGGCATAATAGCCAATCATAGTCAGGTGGAAATTCATTCAGCGTCATCACGACCCAT
TGCATATAAGGCAGACCCTC

Downstream 100 bases:

>100_bases
GAAAATCTCTATGAATGTGCCTGACGATATTCTCAGCGACAGCGAACTCTTAAGATACAGCCGTCAGATCTCCATCAAAG
CCATGGATATCGACGGCCAA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSVKADPCSQPSLMHPDQAIPLLLEQVSPVSDTEVVLLPHALGRVLAEDLASCIDLPPFDNSSMDGYAFRFVDLNTQTNR
TSLRLIGTSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTVQMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLT
AGIQIGAAELGVLATIGISQVRVYRQLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPE
AIRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGKAVFCGLPGNPVSSMVTFYKL
VWPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGILSRNAQGKLEVDITGSQGSGMLTSMSLANCFVLLEQFQGD
TAAGTQVTVEPFNSVLC

Sequences:

>Translated_417_residues
MSVKADPCSQPSLMHPDQAIPLLLEQVSPVSDTEVVLLPHALGRVLAEDLASCIDLPPFDNSSMDGYAFRFVDLNTQTNR
TSLRLIGTSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTVQMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLT
AGIQIGAAELGVLATIGISQVRVYRQLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPE
AIRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGKAVFCGLPGNPVSSMVTFYKL
VWPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGILSRNAQGKLEVDITGSQGSGMLTSMSLANCFVLLEQFQGD
TAAGTQVTVEPFNSVLC
>Mature_416_residues
SVKADPCSQPSLMHPDQAIPLLLEQVSPVSDTEVVLLPHALGRVLAEDLASCIDLPPFDNSSMDGYAFRFVDLNTQTNRT
SLRLIGTSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTVQMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLTA
GIQIGAAELGVLATIGISQVRVYRQLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPEA
IRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGKAVFCGLPGNPVSSMVTFYKLV
WPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGILSRNAQGKLEVDITGSQGSGMLTSMSLANCFVLLEQFQGDT
AAGTQVTVEPFNSVLC

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=393, Percent_Identity=36.6412213740458, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI10880983, Length=393, Percent_Identity=36.6412213740458, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI1787049, Length=405, Percent_Identity=49.1358024691358, Blast_Score=381, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI25147659, Length=395, Percent_Identity=30.379746835443, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=323, Percent_Identity=29.7213622291022, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136978, Length=378, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24638841, Length=378, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44852; Mature: 44721

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKADPCSQPSLMHPDQAIPLLLEQVSPVSDTEVVLLPHALGRVLAEDLASCIDLPPFD
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCC
NSSMDGYAFRFVDLNTQTNRTSLRLIGTSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTV
CCCCCCEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCE
QMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLTAGIQIGAAELGVLATIGISQ
EECCCCCCCCCEEEEECCCCCCCCEEECCHHHCCCCEEEEECCEECHHHHHHHHHCCHHH
VRVYRQLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPE
HHHHHHHEEEEECCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCEEEEEEEEECCHH
AIRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGK
HHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCC
AVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGI
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHH
LSRNAQGKLEVDITGSQGSGMLTSMSLANCFVLLEQFQGDTAAGTQVTVEPFNSVLC
HCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHCCCC
>Mature Secondary Structure 
SVKADPCSQPSLMHPDQAIPLLLEQVSPVSDTEVVLLPHALGRVLAEDLASCIDLPPFD
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCC
NSSMDGYAFRFVDLNTQTNRTSLRLIGTSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTV
CCCCCCEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCE
QMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLTAGIQIGAAELGVLATIGISQ
EECCCCCCCCCEEEEECCCCCCCCEEECCHHHCCCCEEEEECCEECHHHHHHHHHCCHHH
VRVYRQLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPE
HHHHHHHEEEEECCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCEEEEEEEEECCHH
AIRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGK
HHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCC
AVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGI
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHH
LSRNAQGKLEVDITGSQGSGMLTSMSLANCFVLLEQFQGDTAAGTQVTVEPFNSVLC
HCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]