Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 160873145

GI number: 160873145

Start: 22014

End: 23177

Strand: Reverse

Name: fadA [H]

Synonym: Sbal195_0019

Alternate gene names: 160873145

Gene position: 23177-22014 (Counterclockwise)

Preceding gene: 160873146

Following gene: 160873144

Centisome position: 0.43

GC content: 49.83

Gene sequence:

>1164_bases
ATGAAACAAGCTGTTATCGTAGACTGCATCCGTACTCCGATGGGCCGCTCAAAGGCTGGCGTATTTCGTAATGTGCGTGC
AGAAACTCTGTCTGCCGAACTAATGAAAGGTCTGTTGCTGCGTAACCCACAACTCGACCCAAACCTGATTGAAGACGTGA
TTTGGGGTTGTGTGCAACAAACCCTAGAGCAAGGCTTCAACATCGCCCGTAACGCTTCGCTATTAGCGGGCATTCCAAAG
ACTGCTGGCGCTGTAACGGTTAACCGCCTATGTGGTTCATCAATGGATGCTATCCACCAAGCTGCACGTGCAATTATGAC
TGGCATGGGCGACACTTTTATTATTGGTGGCGTAGAGCACATGGGCCATGTACCTATGAGCCATGGTGTCGACTTCCACC
CAGGTCTTGCTAACAACGTGGCAAAAGCCTCTGGCATGATGGGTTTAACGGCTGAAATGCTGGGTAAACTGCACGGTATT
ACCCGTGAACAGCAAGATGCTTTTGCGGTACGTTCACACCAACGCGCTTATGCTGCGACGGTTGAAGGCCGCTTTGCCAA
AGAAATCTATGGCATTGAAGGTCACGATGCTAACGGTGCCTTAATTAAAGTACTGCAAGACGAAGTGATCCGCCCAGAAA
CTACCATGGAATCTTTGGCTGCACTGCGTCCCGTATTTGATCCAGTAAACGGTACTGTGACTGCTGGTACTTCTTCTGCA
CTGTCTGATGGCGCCTCAGCCATGTTGATCATGGAAGAATCTAAAGCGCGTGCACTTGGCTTACCAATTCGTGCACGCAT
TCGCTCTATGGCGGTTGCAGGTTGTGACGCGGCTATTATGGGTTACGGCCCAGTGCCAGCCACGCAAAAAGCACTGGCTC
GCGCTGGTATCACAGTTGCCGATTTAGATGTGATTGAACTTAACGAAGCGTTTGCTGCTCAGTCTTTACCTTGTGTGAAA
GATTTAGGTTTAGCAGATGTGGTTGATGACAAAATCAACCTCAACGGCGGCGCAATTGCACTAGGTCACCCACTGGGTTG
TTCAGGCGCTCGTATCTCTACGACGCTGATCAACTTAATGGAAGACAAAGACGCGACCTTAGGGTTAGCGACCATGTGTA
TTGGTTTAGGCCAAGGTATCGCCACTGTATTCGAACGCGTTTAA

Upstream 100 bases:

>100_bases
CACTTGGGCGGTCTGTATCAAGTCACAGATGCGATGCGCACATTAGCAGCCAATAACGGTAGCTACTACCAAGCCTAATT
AGCGGGAAAGGAATTTAATC

Downstream 100 bases:

>100_bases
ATCGTTACTCGAATAATTTCAAAGCCGGAACTTGTTCCGGCTTTTTTATGCCAAATTTTCTGCCAGCGTAAATATTAATA
TTTCTCATTTCTTCTGCTGT

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKQAVIVDCIRTPMGRSKAGVFRNVRAETLSAELMKGLLLRNPQLDPNLIEDVIWGCVQQTLEQGFNIARNASLLAGIPK
TAGAVTVNRLCGSSMDAIHQAARAIMTGMGDTFIIGGVEHMGHVPMSHGVDFHPGLANNVAKASGMMGLTAEMLGKLHGI
TREQQDAFAVRSHQRAYAATVEGRFAKEIYGIEGHDANGALIKVLQDEVIRPETTMESLAALRPVFDPVNGTVTAGTSSA
LSDGASAMLIMEESKARALGLPIRARIRSMAVAGCDAAIMGYGPVPATQKALARAGITVADLDVIELNEAFAAQSLPCVK
DLGLADVVDDKINLNGGAIALGHPLGCSGARISTTLINLMEDKDATLGLATMCIGLGQGIATVFERV

Sequences:

>Translated_387_residues
MKQAVIVDCIRTPMGRSKAGVFRNVRAETLSAELMKGLLLRNPQLDPNLIEDVIWGCVQQTLEQGFNIARNASLLAGIPK
TAGAVTVNRLCGSSMDAIHQAARAIMTGMGDTFIIGGVEHMGHVPMSHGVDFHPGLANNVAKASGMMGLTAEMLGKLHGI
TREQQDAFAVRSHQRAYAATVEGRFAKEIYGIEGHDANGALIKVLQDEVIRPETTMESLAALRPVFDPVNGTVTAGTSSA
LSDGASAMLIMEESKARALGLPIRARIRSMAVAGCDAAIMGYGPVPATQKALARAGITVADLDVIELNEAFAAQSLPCVK
DLGLADVVDDKINLNGGAIALGHPLGCSGARISTTLINLMEDKDATLGLATMCIGLGQGIATVFERV
>Mature_387_residues
MKQAVIVDCIRTPMGRSKAGVFRNVRAETLSAELMKGLLLRNPQLDPNLIEDVIWGCVQQTLEQGFNIARNASLLAGIPK
TAGAVTVNRLCGSSMDAIHQAARAIMTGMGDTFIIGGVEHMGHVPMSHGVDFHPGLANNVAKASGMMGLTAEMLGKLHGI
TREQQDAFAVRSHQRAYAATVEGRFAKEIYGIEGHDANGALIKVLQDEVIRPETTMESLAALRPVFDPVNGTVTAGTSSA
LSDGASAMLIMEESKARALGLPIRARIRSMAVAGCDAAIMGYGPVPATQKALARAGITVADLDVIELNEAFAAQSLPCVK
DLGLADVVDDKINLNGGAIALGHPLGCSGARISTTLINLMEDKDATLGLATMCIGLGQGIATVFERV

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=41.025641025641, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI167614485, Length=399, Percent_Identity=37.34335839599, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=38.0352644836272, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=31.4814814814815, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=31.9095477386935, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=238, Percent_Identity=33.6134453781513, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI48994986, Length=387, Percent_Identity=72.3514211886305, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1787663, Length=406, Percent_Identity=46.0591133004926, Blast_Score=323, Evalue=9e-90,
Organism=Escherichia coli, GI1788554, Length=401, Percent_Identity=44.6384039900249, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=42.14463840399, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=33.9024390243902, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=361, Percent_Identity=38.5041551246537, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=400, Percent_Identity=34.25, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=30.6976744186047, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=32.0802005012531, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=389, Percent_Identity=26.9922879177378, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322031, Length=392, Percent_Identity=38.5204081632653, Blast_Score=218, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=34.8148148148148, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=37.6558603491272, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI17648125, Length=363, Percent_Identity=37.465564738292, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=33.2552693208431, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=31.8295739348371, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40577; Mature: 40577

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAVIVDCIRTPMGRSKAGVFRNVRAETLSAELMKGLLLRNPQLDPNLIEDVIWGCVQQ
CCCCEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLEQGFNIARNASLLAGIPKTAGAVTVNRLCGSSMDAIHQAARAIMTGMGDTFIIGGVEH
HHHHCCCHHCCCHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECHHH
MGHVPMSHGVDFHPGLANNVAKASGMMGLTAEMLGKLHGITREQQDAFAVRSHQRAYAAT
HCCCCHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHH
VEGRFAKEIYGIEGHDANGALIKVLQDEVIRPETTMESLAALRPVFDPVNGTVTAGTSSA
HCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCHH
LSDGASAMLIMEESKARALGLPIRARIRSMAVAGCDAAIMGYGPVPATQKALARAGITVA
HCCCCCEEEEEECCCCHHCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCEEE
DLDVIELNEAFAAQSLPCVKDLGLADVVDDKINLNGGAIALGHPLGCSGARISTTLINLM
CCCCEECCHHHHHCCCCHHHHCCCHHHHCCCEECCCCEEEECCCCCCCCCHHHHHHHHHH
EDKDATLGLATMCIGLGQGIATVFERV
HCCCCHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MKQAVIVDCIRTPMGRSKAGVFRNVRAETLSAELMKGLLLRNPQLDPNLIEDVIWGCVQQ
CCCCEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLEQGFNIARNASLLAGIPKTAGAVTVNRLCGSSMDAIHQAARAIMTGMGDTFIIGGVEH
HHHHCCCHHCCCHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECHHH
MGHVPMSHGVDFHPGLANNVAKASGMMGLTAEMLGKLHGITREQQDAFAVRSHQRAYAAT
HCCCCHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHH
VEGRFAKEIYGIEGHDANGALIKVLQDEVIRPETTMESLAALRPVFDPVNGTVTAGTSSA
HCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCHH
LSDGASAMLIMEESKARALGLPIRARIRSMAVAGCDAAIMGYGPVPATQKALARAGITVA
HCCCCCEEEEEECCCCHHCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCEEE
DLDVIELNEAFAAQSLPCVKDLGLADVVDDKINLNGGAIALGHPLGCSGARISTTLINLM
CCCCEECCHHHHHCCCCHHHHCCCHHHHCCCEECCCCEEEECCCCCCCCCHHHHHHHHHH
EDKDATLGLATMCIGLGQGIATVFERV
HCCCCHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA