Definition Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
Accession NC_000964
Length 4,215,606

Click here to switch to the map view.

The map label for this gene is argI

Identifier: 16081084

GI number: 16081084

Start: 4141711

End: 4142601

Strand: Reverse

Name: argI

Synonym: BSU40320

Alternate gene names: 16081084

Gene position: 4142601-4141711 (Counterclockwise)

Preceding gene: 16081085

Following gene: 16081081

Centisome position: 98.27

GC content: 49.83

Gene sequence:

>891_bases
ATGGATAAAACGATTTCGGTTATTGGAATGCCAATGGATTTAGGACAAGCACGACGCGGAGTGGATATGGGCCCGAGTGC
CATCCGGTACGCTCATCTGATCGAGAGGCTGTCAGACATGGGGTATACGGTTGAAGATCTCGGTGACATTCCGATCAATC
GCGAAAAAATCAAAAATGACGAGGAACTGAAAAACCTGAATTCCGTTTTGGCGGGAAATGAAAAACTCGCGCAAAAGGTC
AACAAAGTCATTGAAGAGAAAAAATTCCCGCTTGTCCTGGGCGGTGACCACAGTATTGCGATCGGCACGCTTGCAGGCAC
AGCGAAGCATTACGATAATCTCGGCGTCATCTGGTATGACGCGCACGGCGATTTGAATACACTTGAAACTTCACCATCGG
GCAATATTCACGGCATGCCGCTCGCGGTCAGCCTAGGCATTGGCCACGAGTCACTGGTTAACCTTGAAGGCTACGCGCCT
AAAATCAAACCGGAAAACGTCGTCATCATTGGCGCCCGGTCACTTGATGAAGGGGAGCGCAAGTACATTAAGGAAAGCGG
CATGAAGGTGTACACAATGCACGAAATCGATCGTCTTGGCATGACAAAGGTCATTGAAGAAACCCTTGATTATTTATCAG
CATGTGATGGCGTCCATCTGAGCCTTGATCTGGACGGACTTGATCCGAACGACGCACCGGGTGTCGGAACCCCTGTCGTC
GGCGGCATCAGCTACCGGGAGAGCCATTTGGCTATGGAAATGCTGTATGACGCAGGCATCATTACCTCAGCCGAATTCGT
TGAGGTTAACCCGATCCTTGATCACAAAAACAAAACGGGCAAAACAGCAGTAGAGCTCGTAGAATCCCTGTTAGGGAAGA
AGCTGCTGTAA

Upstream 100 bases:

>100_bases
CAGGCAAATCGTCAGCTAGAGCTTTAAAAACGTTGTCCGCAAGTCATCTTTGTTATAACCCGCATAGGACATTATCTTAA
ATGTTGAGGTGGAATCACAG

Downstream 100 bases:

>100_bases
TAAGAAAACCCCCGCACCCGCGGGGGTTTCAGCGTGTCGACAAACCCTCGCATTCGTTGTCAGGCCTGCGCTTCGGTGCT
CACGAATTCCAAACATTCGC

Product: arginase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKV
NKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP
KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGVHLSLDLDGLDPNDAPGVGTPVV
GGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKLL

Sequences:

>Translated_296_residues
MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKV
NKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP
KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGVHLSLDLDGLDPNDAPGVGTPVV
GGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKLL
>Mature_296_residues
MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKV
NKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP
KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGVHLSLDLDGLDPNDAPGVGTPVV
GGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKLL

Specific function: Controls arginine catabolism

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family

Homologues:

Organism=Homo sapiens, GI10947139, Length=302, Percent_Identity=42.0529801324503, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4502215, Length=302, Percent_Identity=39.0728476821192, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI37537722, Length=299, Percent_Identity=26.4214046822742, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1789306, Length=296, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71996843, Length=242, Percent_Identity=36.7768595041322, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6325146, Length=325, Percent_Identity=30.7692307692308, Blast_Score=166, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24638886, Length=311, Percent_Identity=34.4051446945338, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGI_BACSU (P39138)

Other databases:

- EMBL:   X81802
- EMBL:   D78193
- EMBL:   AL009126
- PIR:   S55795
- RefSeq:   NP_391912.1
- ProteinModelPortal:   P39138
- SMR:   P39138
- EnsemblBacteria:   EBBACT00000002520
- GeneID:   937760
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU40320
- NMPDR:   fig|224308.1.peg.4038
- GenoList:   BSU40320
- GeneTree:   EBGT00050000001627
- HOGENOM:   HBG391953
- OMA:   CMEMIAD
- PhylomeDB:   P39138
- ProtClustDB:   CLSK873473
- BioCyc:   BSUB:BSU40320-MONOMER
- BRENDA:   3.5.3.1
- InterPro:   IPR014033
- InterPro:   IPR006035
- InterPro:   IPR020855
- Gene3D:   G3DSA:3.40.800.10
- PANTHER:   PTHR11358:SF2
- PANTHER:   PTHR11358
- PRINTS:   PR00116
- TIGRFAMs:   TIGR01229

Pfam domain/function: PF00491 Arginase

EC number: =3.5.3.1

Molecular weight: Translated: 32154; Mature: 32154

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS01053 ARGINASE_1; PS51409 ARGINASE_2; PS00147 ARGINASE_1 ; PS00148 ARGINASE_2

Important sites: BINDING 176-176 BINDING 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREKIKND
CCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCH
EELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYD
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCEEEEEHHCCHHHHCCCEEEEEE
AHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAPKIKPENVVIIGARSLDEGER
CCCCCCEEECCCCCCCCCCEEEEEECCCHHHEEECCCCCCCCCCCCEEEEECCCCCHHHH
KYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGVHLSLDLDGLDPNDAPGVGTPVV
HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
GGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKLL
CCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREKIKND
CCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCH
EELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYD
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCEEEEEHHCCHHHHCCCEEEEEE
AHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAPKIKPENVVIIGARSLDEGER
CCCCCCEEECCCCCCCCCCEEEEEECCCHHHEEECCCCCCCCCCCCEEEEECCCCCHHHH
KYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGVHLSLDLDGLDPNDAPGVGTPVV
HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
GGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKLL
CCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7540694; 9384377