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The map label for this gene is htpG

Identifier: 16081033

GI number: 16081033

Start: 4089429

End: 4091309

Strand: Reverse

Name: htpG

Synonym: BSU39820

Alternate gene names: 16081033

Gene position: 4091309-4089429 (Counterclockwise)

Preceding gene: 16081034

Following gene: 16081027

Centisome position: 97.05

GC content: 44.23

Gene sequence:

>1881_bases
GTGGCGAAAAAAGAGTTTAAAGCAGAGTCTAAACGCTTGCTGGATATGATGATTAACTCCATTTATACCCAAAAAGAAAT
TTTCCTGCGCGAGTTAATCTCCAATTCGAGTGATGCGATTGACAAAATCTATTACAAAGCGCTTACGGACGATGCGCTTA
CGTTTGATAAAGACAGTTACTACATAAAGGTCGCAGCTGACAAAGATGCGAGAACATTAACCATCTCTGATACGGGGATC
GGAATGACAAAGGATGAGCTTGAACAGCATCTTGGAACAATTGCAAAAAGCGGTTCCCTCGCGTTTAAAAAGGAAAACGA
GCTGAAAGACGGACATGACATTATCGGGCAGTTCGGTGTCGGTTTTTACGCGGCATTTATGGTTGCCGATGTCGTGACAG
TCATCAGTAAAGCGCTTGGCAGCGAAGAGGCTTATAAATGGGAGTCTGCGGGTGCAGACGGCTATACGATTGAGCCGTGT
GAAAAGGATTCTGTCGGTACAGACATTATCCTGAAAATCAAAGAGAACACAGAAGATGACAGCTATGACGAGTTTTTAGA
GGAATATCGTTTAAAAGCGATCATCAAGAAGTACTCCGACTTCATTCGCTACCCGATCAAAATGGATACAACCATTAATA
AGCCGAAGGAAGGCAGCGAAAATGAATTTGAAGAGGTGCAGGAAGAGCAGACGGTCAACAGCATGGTGCCGATCTGGAGA
AAAAACAAAAGCGAGCTGACAGATGAGGATTATGAAAAATTCTATGCTGAAAAGCATTACGGGTTTGATAAACCGCTGAC
ACACGTTCATATCAGCGTGGATGGAGCGGTTCGCTACAACGCGATTCTATTCGTCCCTGAAAACATGCCGTTTGACTACT
ATTCCAAGGAATATGAGAAAGGCTTGGAGCTGTATTCCAATGGCGTGCTGATCATGAATAAGTGCGCAGACCTGCTACCG
GACCACTTCAGCTTTGTGAAGGGCATGGTCGATTCTGAGGATCTGTCGCTGAATATTTCCAGAGAAATGCTGCAGCATGA
CCGCCAGCTGAAGCTGATCGCGAAAAACATCAGCAAGAAAATCAAAAGCGAGCTGCAAAGCCTGTTGAAAAAAGACCGCG
AGAAATACGAGACGTTCTACAAGTCGTTCGGCAGACAGCTGAAATTCGGCGTGTACAATGATTTTGGCGCGAATAAGGAT
CAATTGAAGGATCTCCTCTTATTCTACTCTTCAAAAGAGAAAAAACTGGTCAGCTTAGACGAGTATGTTTCCAGAATGCC
AGAGGAGCAGAAATTCATTTATTACGCGACCGGTGATTCTTACGACCGCATTGAGAAACTGCCGCAAACGGAAATGGTGG
CGGACAAAGGCTATGAAATCCTCTACTTTACTGAGGACATCGATGAGTTTGCAATTAAAATGCTGGCTTCTTATCAGGAA
AAAGAATTCAAGTCCGTATCAAGCGGAGACCTTGGCATAGACACGGATGAGGATCAAAAGCAGTCCGAGGAAGAGGAAAG
CAAGTATAAGGATCTGTTTGAGGAAATGAAAAACATTCTGTCAGACAAAGTGAAAAACGTCAGAATCTCAAAACGGCTTA
AATCACATCCAGTCTGCCTTGCTGCTGACGGCGAAGTGACAATTGAGATGGAAAAAATCTTAAATGCGATGCCTGACAGC
CAAAATGTGAAGGCGGAAAAAGTGCTGGAAATCAACCCAAATCACGAGGTATTCCAAACACTGCAGGACGCGTTTGAACA
AGATAAAGAGAAGCTGAGCCTGTACACAAACCTTCTGTACAATCAGGCGCTCCTCATCGAAGGCCTGCCGATTCAGGACC
CTGTGGAATTTACGAACAATATTTGCAAGGTCATGGTGTAA

Upstream 100 bases:

>100_bases
TTACATATATATGCATCTATCAATCTAATTGACAATTGTCATCTTATGTGATAAATAGATGCTGAAAAGGGTTTACATAA
TGGTAAAGGAGCGATCAAGA

Downstream 100 bases:

>100_bases
ACAGAAAAAGGAATCGTCTCATAAGGAGACGATTCCTTTTTTTATAATGTACGCTCATTCAGCACTTGGTTTTGGGTGCT
TTTCTTCTTTTTAAACCGTT

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYYKALTDDALTFDKDSYYIKVAADKDARTLTISDTGI
GMTKDELEQHLGTIAKSGSLAFKKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC
EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENEFEEVQEEQTVNSMVPIWR
KNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLP
DHFSFVKGMVDSEDLSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANKD
QLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQTEMVADKGYEILYFTEDIDEFAIKMLASYQE
KEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDS
QNVKAEKVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV

Sequences:

>Translated_626_residues
MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYYKALTDDALTFDKDSYYIKVAADKDARTLTISDTGI
GMTKDELEQHLGTIAKSGSLAFKKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC
EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENEFEEVQEEQTVNSMVPIWR
KNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLP
DHFSFVKGMVDSEDLSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANKD
QLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQTEMVADKGYEILYFTEDIDEFAIKMLASYQE
KEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDS
QNVKAEKVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV
>Mature_625_residues
AKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYYKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIG
MTKDELEQHLGTIAKSGSLAFKKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCE
KDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENEFEEVQEEQTVNSMVPIWRK
NKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPD
HFSFVKGMVDSEDLSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANKDQ
LKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQTEMVADKGYEILYFTEDIDEFAIKMLASYQEK
EFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQ
NVKAEKVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV

Specific function: Molecular chaperone. Has ATPase activity

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family

Homologues:

Organism=Homo sapiens, GI154146191, Length=681, Percent_Identity=38.3259911894273, Blast_Score=401, Evalue=1e-111,
Organism=Homo sapiens, GI153792590, Length=681, Percent_Identity=38.3259911894273, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI20149594, Length=678, Percent_Identity=38.2005899705015, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI4507677, Length=677, Percent_Identity=34.711964549483, Blast_Score=339, Evalue=5e-93,
Organism=Homo sapiens, GI155722983, Length=648, Percent_Identity=32.0987654320988, Blast_Score=311, Evalue=1e-84,
Organism=Escherichia coli, GI1786679, Length=635, Percent_Identity=39.0551181102362, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17559162, Length=663, Percent_Identity=39.2156862745098, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17542208, Length=673, Percent_Identity=36.4041604754829, Blast_Score=345, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI115535205, Length=656, Percent_Identity=32.6219512195122, Blast_Score=299, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI115535167, Length=441, Percent_Identity=37.4149659863946, Blast_Score=256, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6323840, Length=674, Percent_Identity=37.3887240356083, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6325016, Length=676, Percent_Identity=37.2781065088757, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI17647529, Length=678, Percent_Identity=38.4955752212389, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI21357739, Length=674, Percent_Identity=34.272997032641, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24586016, Length=652, Percent_Identity=32.361963190184, Blast_Score=301, Evalue=9e-82,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): HTPG_BACSU (P46208)

Other databases:

- EMBL:   AB005554
- EMBL:   AL009126
- PIR:   H69642
- RefSeq:   NP_391861.1
- ProteinModelPortal:   P46208
- SMR:   P46208
- EnsemblBacteria:   EBBACT00000003809
- GeneID:   937631
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU39820
- NMPDR:   fig|224308.1.peg.3987
- GenoList:   BSU39820
- GeneTree:   EBGT00050000002152
- HOGENOM:   HBG631012
- OMA:   AIYYITA
- PhylomeDB:   P46208
- ProtClustDB:   PRK05218
- BioCyc:   BSUB:BSU39820-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00505
- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.30.565.10
- PANTHER:   PTHR11528
- PIRSF:   PIRSF002583
- PRINTS:   PR00775
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 72259; Mature: 72127

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYYKALTDDALTFDKDSY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCE
YIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKKENELKDGHDIIGQFGV
EEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHH
GFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKDSVGTDIILKIKENTEDD
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
SYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENEFEEVQEEQTVNSMVPIWR
CHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHC
KNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNAILFVPENMPFDYYSKEYEK
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEEEEEECCCCCHHHHHHHHH
GLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNISREMLQHDRQLKLIAKNISKK
HHHHHCCCEEEEHHHHHHCCHHHHHHHCCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHH
IKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANKDQLKDLLLFYSSKEKKLVSLD
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
EYVSRMPEEQKFIYYATGDSYDRIEKLPQTEMVADKGYEILYFTEDIDEFAIKMLASYQE
HHHHHCCCCCCEEEEECCCCHHHHHHCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
KEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMKNILSDKVKNVRISKRLKSHPVCL
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AADGEVTIEMEKILNAMPDSQNVKAEKVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLY
EECCCEEEEHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NQALLIEGLPIQDPVEFTNNICKVMV
CCHHEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYYKALTDDALTFDKDSY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCE
YIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKKENELKDGHDIIGQFGV
EEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHH
GFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKDSVGTDIILKIKENTEDD
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
SYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENEFEEVQEEQTVNSMVPIWR
CHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHC
KNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNAILFVPENMPFDYYSKEYEK
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEEEEEECCCCCHHHHHHHHH
GLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNISREMLQHDRQLKLIAKNISKK
HHHHHCCCEEEEHHHHHHCCHHHHHHHCCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHH
IKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANKDQLKDLLLFYSSKEKKLVSLD
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
EYVSRMPEEQKFIYYATGDSYDRIEKLPQTEMVADKGYEILYFTEDIDEFAIKMLASYQE
HHHHHCCCCCCEEEEECCCCHHHHHHCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
KEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMKNILSDKVKNVRISKRLKSHPVCL
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AADGEVTIEMEKILNAMPDSQNVKAEKVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLY
EECCCEEEEHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NQALLIEGLPIQDPVEFTNNICKVMV
CCHHEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377