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The map label for this gene is galE

Identifier: 16080937

GI number: 16080937

Start: 3989948

End: 3990967

Strand: Reverse

Name: galE

Synonym: BSU38860

Alternate gene names: 16080937

Gene position: 3990967-3989948 (Counterclockwise)

Preceding gene: 16080938

Following gene: 16080935

Centisome position: 94.67

GC content: 48.24

Gene sequence:

>1020_bases
ATGGCAATACTTGTTACTGGCGGTGCCGGTTACATTGGCAGCCACACATGTGTTGAACTATTGAACAGCGGCTACGAGAT
TGTTGTTCTTGATAATCTGTCCAACAGTTCAGCTGAAGCGCTGAACCGTGTCAAGGAGATTACAGGAAAAGATTTAACGT
TCTACGAAGCGGATTTATTGGACCGGGAAGCGGTAGATTCCGTTTTTGCTGAAAATGAAATCGAAGCTGTGATTCATTTT
GCAGGGTTAAAAGCAGTCGGCGAATCTGTGGCGATTCCCCTCAAATATTATCATAACAATTTGACAGGAACGTTTATTTT
ATGCGAGGCCATGGAGAAATACGGCGTCAAGAAAATCGTATTCAGTTCATCTGCGACAGTATACGGCGTTCCGGAAACAT
CGCCGATTACGGAAGACTTTCCATTAGGCGCGACAAATCCTTATGGGCAGACGAAGCTCATGCTTGAACAAATATTGCGT
GATTTGCATACAGCCGACAATGAGTGGAGCGTTGCGCTGCTTCGTTACTTTAACCCGTTCGGCGCGCATCCAAGCGGACG
GATCGGTGAAGACCCGAACGGAATCCCAAATAACCTTATGCCGTATGTGGCACAGGTAGCAGTCGGGAAGCTCGAGCAAT
TAAGCGTATTCGGAAATGACTATCCGACAAAAGACGGGACAGGCGTACGCGATTATATTCACGTCGTTGATCTCGCAGAA
GGCCACGTCAAGGCGCTGGAAAAAGTATTGAACTCTACAGGAGCCGATGCATACAACCTTGGAACAGGCACAGGCTACAG
CGTGCTGGAAATGGTCAAAGCCTTTGAAAAAGTGTCAGGGAAAGAGGTTCCATACCGTTTTGCGGACCGCCGTCCGGGAG
ACATCGCCACATGCTTTGCAGATCCTGCGAAAGCCAAGCGAGAACTAGGCTGGGAAGCGAAACGCGGCCTTGAGGAAATG
TGTGCTGATTCCTGGAGATGGCAGTCTTCTAATGTGAATGGGTATAAGAGTGCGGAATAA

Upstream 100 bases:

>100_bases
AAAAACTATTAATAAACGATTAAACTTCTTAAAAATGGATGTGGACCGGTTCTAAACACTATATAATGAAAACAGGTCAT
TTTTTAGGAGGGTTTACATC

Downstream 100 bases:

>100_bases
GAATGGAGGCCTTCTCAATTGAGAAGGCCTTTTTTAAAGAACAAGGGTGCCTAAACAGGCACCCTTGTTAGCTGTTATTT
GATTTTCACAATAACATCAT

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRVKEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHF
AGLKAVGESVAIPLKYYHNNLTGTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR
DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIHVVDLAE
GHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFEKVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEM
CADSWRWQSSNVNGYKSAE

Sequences:

>Translated_339_residues
MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRVKEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHF
AGLKAVGESVAIPLKYYHNNLTGTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR
DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIHVVDLAE
GHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFEKVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEM
CADSWRWQSSNVNGYKSAE
>Mature_338_residues
AILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRVKEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFA
GLKAVGESVAIPLKYYHNNLTGTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILRD
LHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIHVVDLAEG
HVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFEKVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMC
ADSWRWQSSNVNGYKSAE

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=60, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=60, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=60, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI7657641, Length=349, Percent_Identity=24.9283667621776, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI42516563, Length=322, Percent_Identity=26.3975155279503, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=57.4404761904762, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1788353, Length=363, Percent_Identity=27.8236914600551, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI48994969, Length=362, Percent_Identity=25.6906077348066, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982035, Length=347, Percent_Identity=56.4841498559078, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71982038, Length=349, Percent_Identity=56.1604584527221, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17568069, Length=341, Percent_Identity=27.5659824046921, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17539532, Length=271, Percent_Identity=24.3542435424354, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133901786, Length=351, Percent_Identity=24.2165242165242, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=351, Percent_Identity=24.2165242165242, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=351, Percent_Identity=24.2165242165242, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=351, Percent_Identity=24.2165242165242, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=351, Percent_Identity=24.2165242165242, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=55.1020408163265, Blast_Score=393, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=63.7426900584795, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GALE_BACSU (P55180)

Other databases:

- EMBL:   X99339
- EMBL:   D83026
- EMBL:   AL009126
- PIR:   D69628
- RefSeq:   NP_391765.1
- ProteinModelPortal:   P55180
- SMR:   P55180
- EnsemblBacteria:   EBBACT00000001031
- GeneID:   937420
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU38860
- NMPDR:   fig|224308.1.peg.3891
- GenoList:   BSU38860
- GeneTree:   EBGT00070000032003
- HOGENOM:   HBG755066
- OMA:   SSWHWQS
- PhylomeDB:   P55180
- ProtClustDB:   CLSK888129
- BioCyc:   BSUB:BSU38860-MONOMER
- BioCyc:   MetaCyc:MONOMER-9104
- BRENDA:   5.1.3.2
- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF39
- PRINTS:   PR01713
- TIGRFAMs:   TIGR01179

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.2

Molecular weight: Translated: 37009; Mature: 36878

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: ACT_SITE 148-148 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRVKEITGKDLTFYEADLL
CEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHH
DREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLTGTFILCEAMEKYGVKKIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEHHHHCCCCCHHHHHHHHHHHCCCEEEE
FSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILRDLHTADNEWSVALLRYFNPF
EECCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
GAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIHVVDLAE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
GHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFEKVSGKEVPYRFADRRPGDIATCFA
HHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEECC
DPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNGYKSAE
CHHHHHHHCCCHHHHCHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRVKEITGKDLTFYEADLL
EEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHH
DREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLTGTFILCEAMEKYGVKKIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEHHHHCCCCCHHHHHHHHHHHCCCEEEE
FSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILRDLHTADNEWSVALLRYFNPF
EECCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
GAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIHVVDLAE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
GHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFEKVSGKEVPYRFADRRPGDIATCFA
HHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEECC
DPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNGYKSAE
CHHHHHHHCCCHHHHCHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377