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The map label for this gene is mta

Identifier: 16080713

GI number: 16080713

Start: 3764133

End: 3764906

Strand: Reverse

Name: mta

Synonym: BSU36600

Alternate gene names: 16080713

Gene position: 3764906-3764133 (Counterclockwise)

Preceding gene: 16080715

Following gene: 16080711

Centisome position: 89.31

GC content: 44.32

Gene sequence:

>774_bases
ATGAAATATCAAGTTAAACAAGTGGCGGAGATATCAGGCGTTAGCATTCGGACGCTTCATCACTATGACAATATTGAGCT
TCTGAATCCTTCAGCGCTTACTGATGCTGGGTATCGTTTGTACAGTGACGCAGACCTGGAAAGACTGCAACAGATTTTAT
TTTTCAAGGAAATCGGGTTTCGTCTGGATGAGATTAAAGAGATGCTGGATCATCCGAATTTTGACCGGAAAGCGGCACTT
CAGTCGCAAAAGGAGATATTGATGAAGAAAAAACAAAGAATGGATGAGATGATTCAAACAATTGACAGGACGCTTTTGTC
CGTTGATGGAGGGGAAACGATGAATAAGAGGGATTTATTTGCCGGATTAAGCATGAAAGACATTGAAGAGCACCAGCAGA
CATACGCTGATGAAGTCAGAAAGCTGTATGGAAAGGAAATCGCAGAAGAAACAGAGAAAAGGACATCTGCATACTCGGCA
GATGATTGGCGCACGATCATGGCTGAATTTGATTCGATTTACAGACGAATTGCGGCGCGAATGAAGCATGGGCCCGATGA
TGCAGAGATTCAGGCCGCTGTGGGGGCATTTCGCGATCATATTTGCCAATATCATTACGATTGCACACTCGACATTTTCA
GAGGACTCGGGGAAGTGTATATCACTGACGAGCGATTTACCGATTCAATCAATCAATATGGAGAAGGTCTTGCCGCTTTT
TTGCGGGAGGCAATCATCATTTACTGTGACCATCAGGAAAACCCCCGGCCGTAA

Upstream 100 bases:

>100_bases
TACACTATTTGTGAGAAGTTTTGTATATAGAAAATAACATTTTGGGGATTGACCCTAACGTTGCGTGATTGTTTACGATA
AAAAAGAGGAGGTGTTATGT

Downstream 100 bases:

>100_bases
AGGCCGGGGGTTTACGCATCTTATAAGATCGGCGACAACAGCCGCGAGACGGATTCTTTTATTCGAATCCACAACGGGCG
CTGCAGATACTCCTCATAGG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Multidrug transporter activation protein

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDADLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAAL
QSQKEILMKKKQRMDEMIQTIDRTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA
DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGEVYITDERFTDSINQYGEGLAAF
LREAIIIYCDHQENPRP

Sequences:

>Translated_257_residues
MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDADLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAAL
QSQKEILMKKKQRMDEMIQTIDRTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA
DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGEVYITDERFTDSINQYGEGLAAF
LREAIIIYCDHQENPRP
>Mature_257_residues
MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDADLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAAL
QSQKEILMKKKQRMDEMIQTIDRTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA
DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGEVYITDERFTDSINQYGEGLAAF
LREAIIIYCDHQENPRP

Specific function: Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTA_BACSU (P71039)

Other databases:

- EMBL:   Y08559
- EMBL:   AL009126
- PIR:   C69661
- RefSeq:   NP_391541.1
- PDB:   1JBG
- PDB:   1R8D
- PDBsum:   1JBG
- PDBsum:   1R8D
- ProteinModelPortal:   P71039
- EnsemblBacteria:   EBBACT00000000479
- GeneID:   936962
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU36600
- NMPDR:   fig|224308.1.peg.3667
- GenoList:   BSU36600
- GeneTree:   EBGT00050000001456
- HOGENOM:   HBG700494
- OMA:   PAKSENG
- ProtClustDB:   CLSK2752536
- BioCyc:   BSUB:BSU36600-MONOMER
- GO:   GO:0005737
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358
- PRINTS:   PR00040
- SMART:   SM00422

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS; SSF46955 Putativ_DNA_bind

EC number: NA

Molecular weight: Translated: 29936; Mature: 29936

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00552 HTH_MERR_1; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDADLERLQQILFFKEIGF
CCCHHHHHHHHCCCEEEEEECCCCCEEECCHHHHHCCCHHCCHHHHHHHHHHHHHHHHCC
RLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTIDRTLLSVDGGETMNKRDLF
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
AGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSADDWRTIMAEFDSIYRRIAAR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGEVYITDERFTDSINQYGEGLAAF
HHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHH
LREAIIIYCDHQENPRP
HHHHHEEEECCCCCCCC
>Mature Secondary Structure
MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDADLERLQQILFFKEIGF
CCCHHHHHHHHCCCEEEEEECCCCCEEECCHHHHHCCCHHCCHHHHHHHHHHHHHHHHCC
RLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTIDRTLLSVDGGETMNKRDLF
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
AGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSADDWRTIMAEFDSIYRRIAAR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGEVYITDERFTDSINQYGEGLAAF
HHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHH
LREAIIIYCDHQENPRP
HHHHHEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377