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The map label for this gene is ywrD

Identifier: 16080663

GI number: 16080663

Start: 3719134

End: 3720711

Strand: Reverse

Name: ywrD

Synonym: BSU36100

Alternate gene names: 16080663

Gene position: 3720711-3719134 (Counterclockwise)

Preceding gene: 16080667

Following gene: 16080659

Centisome position: 88.26

GC content: 50.25

Gene sequence:

>1578_bases
ATGAACAAATCTGTCATCGGTACAAAGCAAATGGTCGTCAGTCCGCATTATCTCGCTTCTCAAGCCGGAAACCGCATACT
GGATAAGGGAGGCAACGCGTTTGACGCCGCTGTTGCGGTGAGTGCTTGTCTTGCGGTTGTGTACCCGCATATGACCGGAC
TTGGCGGGGATTCCTTTTGGCTGACCTTTCACCAGGAAACAAAGGCAGTAAAAGTCTACAATGGCAGCGGCCGTTCAGGA
AAAAACGTAACGAGAGATGTATATAAGGGAAAAAGCGCGATTCCGCTGCGGGGAATTGACAGTGCTATTACCGTGCCGGG
AATGGTTGATAGCTGGGATGCGGTCCTGAAGGAGTACGGGCGTCTGTCTCTTGCAGATGTATTGGAGCCCGCACGCGATT
ATGCCCAAAATGGGTTTCCTGTATCAGCTGATCAGTGTCGTCACACAGAAAAGAATATTGAACTGCTGGCTTCCACGCCT
TACACGGCTGACATCTTCACGAGAAGGGGCAAAGCACCTGTCCCGGGAGAGCGGTTTGTGCAAAAAGAGCTTGCAGACAG
TCTGAACTTGATTGCTGAAAAAGGAAGAAGCGCATTTTATGAAGGAGATCTCGCTCAGCGGATTGTCTCACATTTACAGA
ATAACGGCAGTTACATGACAATCGATGATTTTAAAGCGCATCGGGGTGAGTGGGCAGCGCCTGTATCAAGTGATTATCGA
GGATACAGTGTGTATCAGGCGCCGCCGAATTCTCAGGGATTTACCGGTTTATTAACACTGAACATTTTGGAAAACTATGA
TTTCACCCAAATCGAACACGGTTCATTTGAGTATTATCACGTGCTTGTGGAGGCATTGAAAAAGAGTTTTCTAGATCGGG
ATGCCGTCCTGACTGATCCGGCGTTTGCAGACATTCCGCTTGAAAGGCTTTTGGACAAACGTTATGCAAAACAATTGGCA
GAAGAAATCGGCTATCTCGCAATACCGGCAGAAAGCAGGCCGGTGGGAAGTGATACGGCATATGCGGCCGTAATCGATGC
GGATGGCAACGCAGTGTCATTCATTCAAAGCCTGTACTTTGAATTTGGCTCGGCAGTCACTGCCGGTGATACAGGCATAT
TACTGCAAAACCGCGGATCGTTTTTCTCACTGGATGAAAATCATGTCAACACGCTTGAACCGAGAAAGCGCACCTTCCAT
ACGTTGATGCCGGCTATGGTCTGTAAAGGCGGAAAGCCAAAAATTCTGTACGGCACACAAGGCGGCGAAGGCCAGCCGCA
GACCCAGACGGCCATCATTACCCGAATGCTGGACTACGGAATGCATCCACAGCAGGCAATCAGCGAACCGCGCTGGGTAT
GGGGCAGAACGTGGGGAGAGGAATACGAAGGTCTCAGAGTCGAGGGCAGATTCACAGACAAAACAATCCAAAAACTGAAA
GACAGCGGGCATCTCGTGGAGGTTGTCGGTGACTATGATCCGCTGATGGGACAAGCGGCTGCAATCAAAGTTGATGAAGA
AGGCTTTCTCCAAGGCGGAGCCGATCCTCGGGGAGACGGAGCGGCTGTGGGGATTTAA

Upstream 100 bases:

>100_bases
GCGAAAAGAAGAAAGTTCGTCAGTTTTTCTGCCGGATCAGTAGATGTGAAAAATCAGGCTCCCTATACTGAAGAAAATTT
CTTAAAAAAGGGGACTTGTG

Downstream 100 bases:

>100_bases
ATAACTATAGGGTACAAACATAAATCAAAAGCATAAACATAAGGGAGACCTCTACAATGTGGTACATATACTGTTTATCT
TCAGGTCTATAATGCCACTC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACLAVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSG
KNVTRDVYKGKSAIPLRGIDSAITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP
YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSYMTIDDFKAHRGEWAAPVSSDYR
GYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSFEYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLA
EEIGYLAIPAESRPVGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTLEPRKRTFH
TLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEPRWVWGRTWGEEYEGLRVEGRFTDKTIQKLK
DSGHLVEVVGDYDPLMGQAAAIKVDEEGFLQGGADPRGDGAAVGI

Sequences:

>Translated_525_residues
MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACLAVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSG
KNVTRDVYKGKSAIPLRGIDSAITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP
YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSYMTIDDFKAHRGEWAAPVSSDYR
GYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSFEYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLA
EEIGYLAIPAESRPVGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTLEPRKRTFH
TLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEPRWVWGRTWGEEYEGLRVEGRFTDKTIQKLK
DSGHLVEVVGDYDPLMGQAAAIKVDEEGFLQGGADPRGDGAAVGI
>Mature_525_residues
MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACLAVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSG
KNVTRDVYKGKSAIPLRGIDSAITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP
YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSYMTIDDFKAHRGEWAAPVSSDYR
GYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSFEYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLA
EEIGYLAIPAESRPVGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTLEPRKRTFH
TLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEPRWVWGRTWGEEYEGLRVEGRFTDKTIQKLK
DSGHLVEVVGDYDPLMGQAAAIKVDEEGFLQGGADPRGDGAAVGI

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family

Homologues:

Organism=Homo sapiens, GI73915092, Length=469, Percent_Identity=27.5053304904051, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI73915090, Length=469, Percent_Identity=27.5053304904051, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI73915096, Length=469, Percent_Identity=27.5053304904051, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI73915094, Length=469, Percent_Identity=27.5053304904051, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI113429324, Length=456, Percent_Identity=26.7543859649123, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI113429326, Length=461, Percent_Identity=26.4642082429501, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI109148539, Length=501, Percent_Identity=27.9441117764471, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI153266885, Length=377, Percent_Identity=25.9946949602122, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI153266901, Length=377, Percent_Identity=25.9946949602122, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI153266907, Length=376, Percent_Identity=24.7340425531915, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789856, Length=533, Percent_Identity=33.5834896810507, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17506189, Length=525, Percent_Identity=24.1904761904762, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17542894, Length=516, Percent_Identity=25.3875968992248, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=485, Percent_Identity=23.9175257731959, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI193208245, Length=485, Percent_Identity=23.9175257731959, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI212646519, Length=486, Percent_Identity=23.6625514403292, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI72000294, Length=486, Percent_Identity=23.6625514403292, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161077880, Length=522, Percent_Identity=25.095785440613, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI161077878, Length=522, Percent_Identity=25.095785440613, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24642670, Length=522, Percent_Identity=25.095785440613, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24642666, Length=522, Percent_Identity=25.095785440613, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45551474, Length=522, Percent_Identity=25.095785440613, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI161077496, Length=450, Percent_Identity=24.8888888888889, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI18859893, Length=465, Percent_Identity=24.5161290322581, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI18859741, Length=463, Percent_Identity=21.8142548596112, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YWRD_BACSU (O05218)

Other databases:

- EMBL:   Z93767
- EMBL:   AL009126
- PIR:   F70068
- RefSeq:   NP_391491.1
- HSSP:   P18956
- ProteinModelPortal:   O05218
- SMR:   O05218
- MEROPS:   T03.014
- EnsemblBacteria:   EBBACT00000001606
- GeneID:   936884
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU36100
- NMPDR:   fig|224308.1.peg.3617
- GenoList:   BSU36100
- GeneTree:   EBGT00050000001829
- HOGENOM:   HBG738311
- OMA:   NAVSFIQ
- PhylomeDB:   O05218
- ProtClustDB:   CLSK888003
- BioCyc:   BSUB:BSU36100-MONOMER
- InterPro:   IPR000101
- PANTHER:   PTHR11686
- PRINTS:   PR01210
- TIGRFAMs:   TIGR00066

Pfam domain/function: PF01019 G_glu_transpept

EC number: =2.3.2.2

Molecular weight: Translated: 57487; Mature: 57487

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACLAVVYPHMTGLGGDSFW
CCCCCCCCHHHEECCHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSAITVPGMVDSWDAVLKEYG
EEEECCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHC
RLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTPYTADIFTRRGKAPVPGERFV
CCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCCCHHHHH
QKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSYMTIDDFKAHRGEWAAPVSSDYR
HHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCC
GYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSFEYYHVLVEALKKSFLDRDAVLTDP
CEEEEECCCCCCCCEEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCEECCC
AFADIPLERLLDKRYAKQLAEEIGYLAIPAESRPVGSDTAYAAVIDADGNAVSFIQSLYF
CCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
EFGSAVTAGDTGILLQNRGSFFSLDENHVNTLEPRKRTFHTLMPAMVCKGGKPKILYGTQ
HHCCEEECCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECC
GGEGQPQTQTAIITRMLDYGMHPQQAISEPRWVWGRTWGEEYEGLRVEGRFTDKTIQKLK
CCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHH
DSGHLVEVVGDYDPLMGQAAAIKVDEEGFLQGGADPRGDGAAVGI
CCCCEEEEECCCCCCCCCEEEEEECCCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACLAVVYPHMTGLGGDSFW
CCCCCCCCHHHEECCHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSAITVPGMVDSWDAVLKEYG
EEEECCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHC
RLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTPYTADIFTRRGKAPVPGERFV
CCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCCCHHHHH
QKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSYMTIDDFKAHRGEWAAPVSSDYR
HHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCC
GYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSFEYYHVLVEALKKSFLDRDAVLTDP
CEEEEECCCCCCCCEEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCEECCC
AFADIPLERLLDKRYAKQLAEEIGYLAIPAESRPVGSDTAYAAVIDADGNAVSFIQSLYF
CCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
EFGSAVTAGDTGILLQNRGSFFSLDENHVNTLEPRKRTFHTLMPAMVCKGGKPKILYGTQ
HHCCEEECCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECC
GGEGQPQTQTAIITRMLDYGMHPQQAISEPRWVWGRTWGEEYEGLRVEGRFTDKTIQKLK
CCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHH
DSGHLVEVVGDYDPLMGQAAAIKVDEEGFLQGGADPRGDGAAVGI
CCCCEEEEECCCCCCCCCEEEEEECCCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377