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The map label for this gene is tuaD

Identifier: 16080611

GI number: 16080611

Start: 3654139

End: 3655524

Strand: Reverse

Name: tuaD

Synonym: BSU35580

Alternate gene names: 16080611

Gene position: 3655524-3654139 (Counterclockwise)

Preceding gene: 16080612

Following gene: 16080610

Centisome position: 86.71

GC content: 45.09

Gene sequence:

>1386_bases
GTGAAAAAAATAGCTGTCATTGGAACAGGTTATGTAGGACTCGTATCAGGCACTTGCTTTGCGGAGATCGGCAATAAAGT
TGTTTGCTGTGATATCGATGAATCAAAAATCAGAAGCCTGAAAAATGGGGTAATCCCAATCTATGAACCAGGGCTTGCAG
ACTTAGTTGAAAAAAATGTGCTGGATCAGCGCCTGACCTTTACGAACGATATCCCGTCTGCCATTCGGGCCTCAGATATT
ATTTATATTGCAGTCGGAACGCCTATGTCCAAAACAGGTGAAGCTGATTTAACGTACGTCAAAGCGGCGGCGAAAACAAT
CGGTGAGCATCTTAACGGCTACAAAGTGATCGTAAATAAAAGCACAGTCCCGGTTGGAACAGGGAAACTGGTGCAATCTA
TCGTTCAAAAAGCCTCAAAGGGGAGATACTCATTTGATGTTGTATCTAACCCTGAATTCCTTCGGGAAGGGTCAGCGATT
CATGACACGATGAATATGGAGCGTGCCGTGATTGGTTCAACAAGTCATAAAGCCGCTGCCATCATTGAGGAACTTCATCA
GCCATTCCATGCTCCTGTCATTAAAACAAACCTAGAAAGTGCAGAAATGATTAAATACGCCGCGAATGCATTTCTGGCGA
CAAAGATTTCCTTTATCAACGATATCGCAAACATTTGTGAGCGAGTCGGCGCAGACGTTTCAAAAGTTGCTGATGGTGTT
GGTCTTGACAGCCGTATCGGCAGAAAGTTCCTTAAAGCTGGTATTGGATTCGGCGGTTCATGTTTTCCAAAGGATACAAC
CGCGCTGCTTCAAATCGCAAAATCGGCAGGCTATCCATTCAAGCTCATCGAAGCTGTCATTGAAACGAACGAAAAGCAGC
GTGTTCATATTGTAGATAAACTTTTGACTGTTATGGGAAGCGTCAAAGGGAGAACCATTTCAGTCCTGGGATTAGCCTTC
AAACCGAATACGAACGATGTGAGATCCGCTCCAGCGCTTGATATTATCCCAATGCTGCAGCAGCTGGGCGCCCATGTAAA
AGCATACGATCCGATTGCTATTCCTGAAGCTTCAGCGATCCTTGGCGAACAGGTCGAGTATTACACAGATGTGTATGCTG
CGATGGAAGACACTGATGCATGCCTGATTTTAACGGATTGGCCGGAAGTGAAAGAAATGGAGCTTGTAAAAGTGAAAACC
CTCTTAAAACAGCCAGTCATCATTGACGGCAGAAATTTATTTTCACTTGAAGAGATGCAGGCAGCCGGATACATTTATCA
CTCTATCGGCCGTCCCGCTGTTCGGGGAACGGAACCCTCTGACAAGTATTTTCCGGGCTTGCCGCTTGAAGAATTGGCTA
AAGACTTGGGAAGCGTCAATTTATAA

Upstream 100 bases:

>100_bases
CATCATCAGTATCAGACGGTCACGAAAACGTCCGTTTAATCGTAAGACACTGCGACCATTATAAATTGGAAGATCATTTT
ACAGGAGAGGGTTGAGCGCT

Downstream 100 bases:

>100_bases
AAAGAAAAAGTGTTACTTGGTTGAAGCTGCCGGCTGCTAGGCTCGGCCGCCGGCTCCTGAAACATCAGGAAAGGGGTTAA
ACATGTGAGTATCAAACGAT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGVIPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDI
IYIAVGTPMSKTGEADLTYVKAAAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI
HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVADGV
GLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSAGYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAF
KPNTNDVRSAPALDIIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKEMELVKVKT
LLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLEELAKDLGSVNL

Sequences:

>Translated_461_residues
MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGVIPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDI
IYIAVGTPMSKTGEADLTYVKAAAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI
HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVADGV
GLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSAGYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAF
KPNTNDVRSAPALDIIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKEMELVKVKT
LLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLEELAKDLGSVNL
>Mature_461_residues
MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGVIPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDI
IYIAVGTPMSKTGEADLTYVKAAAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI
HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVADGV
GLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSAGYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAF
KPNTNDVRSAPALDIIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKEMELVKVKT
LLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLEELAKDLGSVNL

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4507813, Length=486, Percent_Identity=34.9794238683128, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI296040438, Length=391, Percent_Identity=35.0383631713555, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI296040443, Length=481, Percent_Identity=30.977130977131, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1788340, Length=356, Percent_Identity=31.1797752808989, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI48994968, Length=359, Percent_Identity=28.6908077994429, Blast_Score=129, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17560350, Length=475, Percent_Identity=35.3684210526316, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=36.0691144708423, Blast_Score=282, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TUAD_BACSU (O32271)

Other databases:

- EMBL:   AF015609
- EMBL:   AL009126
- PIR:   F69727
- RefSeq:   NP_391438.1
- ProteinModelPortal:   O32271
- SMR:   O32271
- PhosSite:   O32271
- EnsemblBacteria:   EBBACT00000000900
- GeneID:   936766
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU35580
- NMPDR:   fig|224308.1.peg.3564
- GenoList:   BSU35580
- GeneTree:   EBGT00050000001585
- HOGENOM:   HBG400967
- OMA:   CLADVGH
- PhylomeDB:   O32271
- ProtClustDB:   CLSK887967
- BioCyc:   BSUB:BSU35580-MONOMER
- BRENDA:   1.1.1.22
- GO:   GO:0005737
- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732
- Gene3D:   G3DSA:1.20.5.100
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11374
- PIRSF:   PIRSF000124
- TIGRFAMs:   TIGR03026

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N; SSF48179 6DGDH_C_like; SSF52413 UDP-Glc/GDP-Man_DH_C

EC number: =1.1.1.22

Molecular weight: Translated: 49816; Mature: 49816

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: ACT_SITE 261-261

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGVIPIYEPGLADLVEKNV
CCEEEEEECCHHHHHCCHHHHHHCCEEEEEECCHHHHHHHHCCCCEEECCCHHHHHHHHH
LDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKAAAKTIGEHLNGYKVIVNK
HHHHHHCCCCCCHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
STVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAIHDTMNMERAVIGSTSHKAAA
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHH
IIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVADGV
HHHHHHCHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSAGYPFKLIEAVIETNEKQRVHIVDK
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHH
LLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALDIIPMLQQLGAHVKAYDPIAIPEASAI
HHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHH
LGEQVEYYTDVYAAMEDTDACLILTDWPEVKEMELVKVKTLLKQPVIIDGRNLFSLEEMQ
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHH
AAGYIYHSIGRPAVRGTEPSDKYFPGLPLEELAKDLGSVNL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGVIPIYEPGLADLVEKNV
CCEEEEEECCHHHHHCCHHHHHHCCEEEEEECCHHHHHHHHCCCCEEECCCHHHHHHHHH
LDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKAAAKTIGEHLNGYKVIVNK
HHHHHHCCCCCCHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
STVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAIHDTMNMERAVIGSTSHKAAA
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHH
IIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVADGV
HHHHHHCHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSAGYPFKLIEAVIETNEKQRVHIVDK
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHH
LLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALDIIPMLQQLGAHVKAYDPIAIPEASAI
HHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHH
LGEQVEYYTDVYAAMEDTDACLILTDWPEVKEMELVKVKTLLKQPVIIDGRNLFSLEEMQ
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHH
AAGYIYHSIGRPAVRGTEPSDKYFPGLPLEELAKDLGSVNL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820