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The map label for this gene is fadE

Identifier: 16080334

GI number: 16080334

Start: 3367040

End: 3368824

Strand: Reverse

Name: fadE

Synonym: BSU32820

Alternate gene names: 16080334

Gene position: 3368824-3367040 (Counterclockwise)

Preceding gene: 16080335

Following gene: 16080333

Centisome position: 79.91

GC content: 47.51

Gene sequence:

>1785_bases
ATGGCAAAAAAAGCGGCTGACGTACAAAAAGGCGGCGGATTTTTAATCGAGGATGTCACATACGATCAAATGTATACACC
GGAGGATTTCACTGACGAGCATAAAATGATTGCGAAAACAACAGAGGATTACATCGAGCAAGATGTTCTCCCTCATATAG
ATGATATCGAAAACCATCAATTCGAGCATTCTGTCAGACTGTTGAAGAAAGCGGGCGAACTAGGGCTGCTTGGCGCCGAT
GTGCCGGAAGAATACGGCGGGCTCGGCCTTGATAAAATCAGCTCGGCACTCATCACTGAGAAATTTTCGCGTGCGGGAAG
CTTTTCTCTTTCTTATGGCGCGCATGTCGGTATCGGTTCCTTGCCGATCGTCTTTTTCGGGTCAGAAGAACAAAAGAAAA
AATATTTGCCTGGACTCGCTTCAGGCGAAAAGATCGCCGCTTATGCTCTGACTGAGCCTGGCTCTGGGTCTGATGCACTT
GGAGCAAAAACAACAGCTGTGCTGAATGAAGCAGGAACCCATTATGTATTAACAGGGGAAAAACAGTGGATTACCAACTC
TGCTTTTGCCGATGTATTTGTAGTTTACGCTAAGGTAGACGGCGACAAGTTTTCAGCCTTTATTGTAGAAAAAGAGTTCC
CGGGTGTCTCCACGGGACCGGAAGAAAAGAAAATGGGAATCAAGGGATCATCGACAAGAACCCTCATTCTGGATCAAGCT
GAAGTGCCAAAGGAAAACCTGCTCGGAGAAATCGGCAAAGGGCATGTCATCGCCTTTAATATTTTAAACATCGGCCGTTA
CAAACTGGCGGTTGGCACAATCGGCGCATCTAAACGCGTCATCGAGCTGTCTGCGGCATACGCAAATCAGCGCCGCCAAT
TTAAAACGCCGATTGCTGGTTTTTCATTGACACAGGAAAAAATCGGGACAATGGCCTCAAGGCTGTATGCGATGGAAAGC
TCTGTATACAGAACCGTCGGGCTGTTTGAAGACAATATGAGCCAGTTCACGGCCGAAGATCTCAAGGACGGCCGGCAAAT
CGCCAAATCGATTGCGGAATACGCCATCGAATGCTCTCTGAATAAGGTATTCGGCTCTGAAACGCTTGATTATATCGTTG
ATGAAGGCGTGCAGATTCATGGAGGCTACGGCTTTATGCAGGAATACGAAGTAGAAAGGGCCTATAGGGATTCAAGGATC
AATCGGATTTTTGAAGGCACAAACGAAATCAACCGGTTAATCGTGCCAAGCACCTTCCTGAAAAAAGCGCTTAAAGGCGA
GCTGCCTTTATTCGAAAAAGCGCAGTCGCTGCAGGAAGAACTCATGATGCTTATGCCTGAAGAGCCTGGAAGCGGCGTCT
TAGAGCAGGAGAAATATATCGTCAAGCAAGCCAAAAAAATTGCGTTGTTTGCTGCCGGCCTAGCCGCGCAAAAATACGGA
AAAGCGATCGATCGTGAGCAAGAAATTCTCGTGAACGTAGCGGATATCGTCAGCAATGTATACGCAATGGAATCAGCCGT
GCTCAGAACGGAAAAGGCCATTGCCGCACAAGGCGCTGAAAAAGCAGCGCAAAAGGTGCTGTACACAGAAATTTTCGTTC
AAGAGGCCTTTAACGAAATCGAAGCGCATGCAAAGGAATCCCTTATCGCAATGGAAGAAGGAGATTCACTCCGCATGATG
CTTTCCGCTCTGCGCAAGCTGACACGCGTAACGCCTAAAAACGTGATTCAGAAAAAACGCGAGGCGGCGGCAGGCATTTT
TGAGGCTGAGAAATATACTGTCTGA

Upstream 100 bases:

>100_bases
TGAAACGGAGAAACGAGCAATTTGGAGTCGTGACCATGTGTATCGGCGGCGGAATGGGAGCGGCCGGTGTATTTGAATTA
TGCTAAAGGGGGAAAAACAA

Downstream 100 bases:

>100_bases
TTGGCCATGAGCTCCGCATGCGCGGAGCTCTTTTTTAAGAAGCACTGTTTTAGGTTTTTAAAACAAACTGTGTTAAAATA
ACCTCGATTATTTTATTGAG

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDYIEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGAD
VPEEYGGLGLDKISSALITEKFSRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL
GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVSTGPEEKKMGIKGSSTRTLILDQA
EVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGASKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMES
SVYRTVGLFEDNMSQFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVERAYRDSRI
NRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPGSGVLEQEKYIVKQAKKIALFAAGLAAQKYG
KAIDREQEILVNVADIVSNVYAMESAVLRTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMM
LSALRKLTRVTPKNVIQKKREAAAGIFEAEKYTV

Sequences:

>Translated_594_residues
MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDYIEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGAD
VPEEYGGLGLDKISSALITEKFSRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL
GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVSTGPEEKKMGIKGSSTRTLILDQA
EVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGASKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMES
SVYRTVGLFEDNMSQFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVERAYRDSRI
NRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPGSGVLEQEKYIVKQAKKIALFAAGLAAQKYG
KAIDREQEILVNVADIVSNVYAMESAVLRTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMM
LSALRKLTRVTPKNVIQKKREAAAGIFEAEKYTV
>Mature_593_residues
AKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDYIEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADV
PEEYGGLGLDKISSALITEKFSRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDALG
AKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVSTGPEEKKMGIKGSSTRTLILDQAE
VPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGASKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESS
VYRTVGLFEDNMSQFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVERAYRDSRIN
RIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPGSGVLEQEKYIVKQAKKIALFAAGLAAQKYGK
AIDREQEILVNVADIVSNVYAMESAVLRTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMML
SALRKLTRVTPKNVIQKKREAAAGIFEAEKYTV

Specific function: Involved in the degradation of long-chain fatty acids

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family

Homologues:

Organism=Homo sapiens, GI21361497, Length=559, Percent_Identity=34.8837209302326, Blast_Score=304, Evalue=2e-82,
Organism=Homo sapiens, GI76496475, Length=584, Percent_Identity=34.4178082191781, Blast_Score=273, Evalue=5e-73,
Organism=Homo sapiens, GI4557235, Length=584, Percent_Identity=34.4178082191781, Blast_Score=272, Evalue=7e-73,
Organism=Homo sapiens, GI4557233, Length=407, Percent_Identity=35.3808353808354, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI226958412, Length=398, Percent_Identity=33.9195979899498, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI7656849, Length=396, Percent_Identity=31.8181818181818, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI226958414, Length=380, Percent_Identity=35.5263157894737, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI4557231, Length=402, Percent_Identity=32.3383084577114, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI187960098, Length=402, Percent_Identity=32.3383084577114, Blast_Score=204, Evalue=3e-52,
Organism=Homo sapiens, GI4501857, Length=392, Percent_Identity=31.1224489795918, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4501859, Length=389, Percent_Identity=31.1053984575836, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI4503943, Length=396, Percent_Identity=31.5656565656566, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI7669494, Length=374, Percent_Identity=31.8181818181818, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI211971008, Length=426, Percent_Identity=23.943661971831, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI48976061, Length=426, Percent_Identity=23.943661971831, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38505218, Length=346, Percent_Identity=23.121387283237, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI87081958, Length=354, Percent_Identity=30.225988700565, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786223, Length=362, Percent_Identity=27.3480662983425, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87081702, Length=358, Percent_Identity=27.3743016759777, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI87082384, Length=338, Percent_Identity=24.2603550295858, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71985184, Length=519, Percent_Identity=37.1868978805395, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=39.6067415730337, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=34.7368421052632, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17538396, Length=392, Percent_Identity=34.6938775510204, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17569725, Length=407, Percent_Identity=33.9066339066339, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17570075, Length=418, Percent_Identity=30.1435406698565, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17508101, Length=388, Percent_Identity=30.9278350515464, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=389, Percent_Identity=32.3907455012853, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17533517, Length=391, Percent_Identity=28.9002557544757, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=400, Percent_Identity=29.25, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=37.0656370656371, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=38.2352941176471, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71982178, Length=284, Percent_Identity=28.169014084507, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17551932, Length=409, Percent_Identity=25.9168704156479, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17505929, Length=408, Percent_Identity=25.9803921568627, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=248, Percent_Identity=25, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=218, Percent_Identity=28.4403669724771, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=289, Percent_Identity=27.3356401384083, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=289, Percent_Identity=27.3356401384083, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281363737, Length=469, Percent_Identity=35.181236673774, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI21356377, Length=409, Percent_Identity=34.9633251833741, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24660351, Length=410, Percent_Identity=32.6829268292683, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24646207, Length=403, Percent_Identity=33.4987593052109, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=33.6814621409922, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24666513, Length=387, Percent_Identity=32.0413436692506, Blast_Score=195, Evalue=9e-50,
Organism=Drosophila melanogaster, GI19920834, Length=399, Percent_Identity=29.0726817042606, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45550141, Length=356, Percent_Identity=25.8426966292135, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473076, Length=356, Percent_Identity=25.8426966292135, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FADE_BACSU (O32176)

Other databases:

- EMBL:   AL009126
- PIR:   C70021
- RefSeq:   NP_391161.1
- HSSP:   P15651
- ProteinModelPortal:   O32176
- SMR:   O32176
- EnsemblBacteria:   EBBACT00000003747
- GeneID:   936717
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU32820
- NMPDR:   fig|224308.1.peg.3287
- GenoList:   BSU32820
- GeneTree:   EBGT00070000031848
- HOGENOM:   HBG699365
- OMA:   ITEKFSR
- ProtClustDB:   CLSK873629
- BioCyc:   BSUB:BSU32820-MONOMER
- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- Gene3D:   G3DSA:2.40.110.10
- Gene3D:   G3DSA:1.10.540.10
- Gene3D:   G3DSA:1.20.140.10

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; SSF56645 AcylCoA_dehyd_NM; SSF47203 AcylCoADH_C_like

EC number: NA

Molecular weight: Translated: 65336; Mature: 65205

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00072 ACYL_COA_DH_1; PS00073 ACYL_COA_DH_2

Important sites: ACT_SITE 405-405

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDYIEQDVLPHIDDIENHQ
CCCCCCCHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCH
FEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKFSRAGSFSLSYGAHVGIGS
HHHHHHHHHHCCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
LPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDALGAKTTAVLNEAGTHYVLTGE
CCEEEECCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCEEEEECC
KQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVSTGPEEKKMGIKGSSTRTLILDQA
HHHHCCHHHHEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECC
EVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGASKRVIELSAAYANQRRQFKTPIAG
CCCHHHHHHHCCCCCEEEEEEEECCEEEEEEEECCCCCCEEEEHHHHHHHHHHHCCCCCC
FSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMSQFTAEDLKDGRQIAKSIAEYAIECSL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKVFGSETLDYIVDEGVQIHGGYGFMQEYEVERAYRDSRINRIFEGTNEINRLIVPSTFL
HHHHCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCEEECCHHHH
KKALKGELPLFEKAQSLQEELMMLMPEEPGSGVLEQEKYIVKQAKKIALFAAGLAAQKYG
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAIDREQEILVNVADIVSNVYAMESAVLRTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
EAHAKESLIAMEEGDSLRMMLSALRKLTRVTPKNVIQKKREAAAGIFEAEKYTV
HHHHHHHEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDYIEQDVLPHIDDIENHQ
CCCCCCHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCH
FEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKFSRAGSFSLSYGAHVGIGS
HHHHHHHHHHCCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
LPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDALGAKTTAVLNEAGTHYVLTGE
CCEEEECCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCEEEEECC
KQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVSTGPEEKKMGIKGSSTRTLILDQA
HHHHCCHHHHEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECC
EVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGASKRVIELSAAYANQRRQFKTPIAG
CCCHHHHHHHCCCCCEEEEEEEECCEEEEEEEECCCCCCEEEEHHHHHHHHHHHCCCCCC
FSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMSQFTAEDLKDGRQIAKSIAEYAIECSL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKVFGSETLDYIVDEGVQIHGGYGFMQEYEVERAYRDSRINRIFEGTNEINRLIVPSTFL
HHHHCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCEEECCHHHH
KKALKGELPLFEKAQSLQEELMMLMPEEPGSGVLEQEKYIVKQAKKIALFAAGLAAQKYG
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAIDREQEILVNVADIVSNVYAMESAVLRTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
EAHAKESLIAMEEGDSLRMMLSALRKLTRVTPKNVIQKKREAAAGIFEAEKYTV
HHHHHHHEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377