BacMap

Definition	Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
Accession	NC_000964
Length	4,215,606

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The map label for this gene is fabG

Identifier: 16079994

GI number: 16079994

Start: 3010661

End: 3011428

Strand: Reverse

Name: fabG

Synonym: BSU29420

Alternate gene names: 16079994

Gene position: 3011428-3010661 (Counterclockwise)

Preceding gene: 255767677

Following gene: 50812279

Centisome position: 71.44

GC content: 47.01

Gene sequence:

>768_bases
GTGCGACATGCTTTAATTACTGCCGGTTCGAAGGGTTTAGGCCGCAAAGTGACTGAAACGTTGCTTGCAAAGGGGTATTC
AGTAACAGTCAATTACAGACAGGATGAGGAGGCAGTCAGCCGCCTGAAGGAAGCCTGTCCCGATTGTCTTGACCGGCTGC
AATTTGTAAAAGGTGATGTCACCAAAAAAGAAGATCTGCTGCGTATTGCAGAGGCTGCCTTAAACCGCTTCGGAAGGATC
GACTTTTTGATTAACAACGCTGGACCATACATATTTGAACGTAAAAAGTTAGCCGATTATACTGATGATGAATGGTATGG
CATGCTGGAAGGAAATTTAAGCGCCGTCTTTCATTTATTCAAAGCGGTTATTCCTATTATGAGAAAACAGCAATTTGGAC
GCATTATTACGTACGGATTCCAAGGTGCGGCTCACGCGCCCGGCTGGCTTCACCGATCGGCATTTGGCGCTGCGAAAGTG
GGCTTGGCTTCTTTGACGAAGACAATTGCCATTGAAGAAGCCGAATTCGGCATAACCGCCAACATGGTTTGCCCAGGAGA
CATTGTCGGCGACATGAAAGAAGCATCGATAGAGGAAGCCAGAATGCGAATCGGCAAAGAAAAAACGCCGATAGGAAGAT
CCGGTACAGGCGAGGATATTGCCAGGATTATCGCTTTCTTGTGTGAGGAGAACTCAGACCTTGTGACAGGGACTGTCATT
GAAGCCACCGGAGGCCTCAATGTCATTAACAAGAATCAAACAACATAA

Upstream 100 bases:

>100_bases
TATGCCAAAGTGTAAAAAGTGATATTGCAAGCCTTTTATAGTAAAGTAGAAGAAGAAACACTTTATTGAAAGCGGCGACG
TTGCTTTGGGAGGTATTCAT

Downstream 100 bases:

>100_bases
GTTTTTCAGCTTTTTAAAAAGGGAAAATAAAAAAAACAAAATCATGTGACGAGGTGAAAGAAATGAAAGTGACATATCAC
GGACATTCTGTAATCACAGT

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKEACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRI
DFLINNAGPYIFERKKLADYTDDEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV
GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGEDIARIIAFLCEENSDLVTGTVI
EATGGLNVINKNQTT

Sequences:

>Translated_255_residues
MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKEACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRI
DFLINNAGPYIFERKKLADYTDDEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV
GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGEDIARIIAFLCEENSDLVTGTVI
EATGGLNVINKNQTT
>Mature_255_residues
MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKEACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRI
DFLINNAGPYIFERKKLADYTDDEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV
GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGEDIARIIAFLCEENSDLVTGTVI
EATGGLNVINKNQTT

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=28.0632411067194, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI32483357, Length=247, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=32.2448979591837, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI59889578, Length=217, Percent_Identity=27.6497695852535, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI66933014, Length=197, Percent_Identity=29.9492385786802, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=29.0196078431373, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI4504505, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=26.6393442622951, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=29.3650793650794, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=25.8964143426295, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=35.4838709677419, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=28.6852589641434, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=27.8884462151394, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=27.9527559055118, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=25.7028112449799, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=25.3012048192771, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI87082100, Length=246, Percent_Identity=27.2357723577236, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=25.5060728744939, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=26.4822134387352, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786812, Length=253, Percent_Identity=26.4822134387352, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=28.968253968254, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=30, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=271, Percent_Identity=31.3653136531365, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=262, Percent_Identity=25.9541984732824, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=27.3809523809524, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=29.7709923664122, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=29.1666666666667, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=276, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=25.1937984496124, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=26.5682656826568, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=27.1255060728745, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=187, Percent_Identity=27.807486631016, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=28.4090909090909, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=271, Percent_Identity=26.9372693726937, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=276, Percent_Identity=27.8985507246377, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=27.0992366412214, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=26.9662921348315, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=25.5725190839695, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=26.9961977186312, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=27.8195488721804, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=25.1908396946565, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=26.5917602996255, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=260, Percent_Identity=25.3846153846154, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=253, Percent_Identity=28.0632411067194, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=26.6932270916335, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=27.6, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=27.6422764227642, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=30.241935483871, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18859837, Length=249, Percent_Identity=27.710843373494, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=27.3809523809524, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=26.8774703557312, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=26.6932270916335, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=24.8031496062992, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YTKK_BACSU (O34308)

Other databases:

- EMBL:   AF008220
- EMBL:   AL009126
- PIR:   F69994
- RefSeq:   NP_390820.1
- HSSP:   Q9BY49
- ProteinModelPortal:   O34308
- SMR:   O34308
- EnsemblBacteria:   EBBACT00000003788
- GeneID:   937351
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU29420
- NMPDR:   fig|224308.1.peg.2945
- GenoList:   BSU29420
- GeneTree:   EBGT00070000031990
- HOGENOM:   HBG750976
- OMA:   DYTDDEW
- ProtClustDB:   PRK12825
- BioCyc:   BSUB:BSU29420-MONOMER
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: 1.1.1.100

Molecular weight: Translated: 27974; Mature: 27974

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKEACPDCLDRLQFVKGDV
CCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
TKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTDDEWYGMLEGNLSAVFHLF
CCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHCCCCCCCCEEEECCCHHHHHHHH
KAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKVGLASLTKTIAIEEAEFGITA
HHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEE
NMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGEDIARIIAFLCEENSDLVTGTVI
EEECCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEE
EATGGLNVINKNQTT
EECCCCEECCCCCCC
>Mature Secondary Structure
MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKEACPDCLDRLQFVKGDV
CCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
TKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTDDEWYGMLEGNLSAVFHLF
CCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHCCCCCCCCEEEECCCHHHHHHHH
KAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKVGLASLTKTIAIEEAEFGITA
HHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEE
NMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGEDIARIIAFLCEENSDLVTGTVI
EEECCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEE
EATGGLNVINKNQTT
EECCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377