Click here to switch to the map view.

The map label for this gene is yrkA

Identifier: 16079714

GI number: 16079714

Start: 2718959

End: 2720263

Strand: Reverse

Name: yrkA

Synonym: BSU26610

Alternate gene names: 16079714

Gene position: 2720263-2718959 (Counterclockwise)

Preceding gene: 255767614

Following gene: 16079711

Centisome position: 64.53

GC content: 36.32

Gene sequence:

>1305_bases
TTGACAACCATTAACCTTATAATCTTTACTCTTTTAATTGTCTTAACAGCATTTTTTGTTGCGACTGAATTTGCGATAGT
AAAGATCAGGTCATCAAAAATTGACCAACTCATATTAGAGGGAAAAAAAGGTGCCATATCAGCCAAAAAGGTCATTACTC
ATTTGGACGAATATTTGTCAGCTTGTCAATTAGGGATCACGGTTACAGCGTTGGGAATTGGCTGGGTCGGAGAATCGACT
TTTGAAGTGATTTTGCACCCCTTATTTGCTCATTTTCATGTAAGTGAAACAGTCTCACATGTATTGATCTTAGTGATTGC
TTTTGTGATGGCGACTTTTTTGCACGTTGTAGTTGGAGAGCTTGCTCCTAAAACACTCGCTATCCAAAAAGCGGAAACCA
TCACTCTTTTGACTGCAAAGCCAATTATTTGGTTTTACCGCATCCTGTTCCCTTTTATATGGTTTTTAAATGGTTCAGCC
CGGTTTATAGTAGGACTCTTCGGTTTGAAACCTGCATCAGAACATGAACTTGCTCATTCTGAAGAAGAACTGCGCATCTT
ACTGTCTGAAAGCTATAAGAGCGGTGAAATCAATCAAAATGAGTTGAAATATGTAAATAATATTTTTGAATTTGATGAAA
GAATCGCCAAAGAAATTATGATTCCGAGAAGAGAGATCGTAGCGATTTCTAGTGAGGATTCTTATGAAACTATTGTTAAG
ATCATTAAGACAGAGAGCTATACAAGGTACCCAGTCCTAAATGGAGATAAAGATTCAATCATTGGTTTTATCAATGCTAA
AGAATTTTTGTCAGCTTATATTGACACAGACCAGAAGATAAAAGAGGATTTCAAGTTAGAAAATCATATCAACCCTGTTA
TCCATGTTATTGAATCCGTTCCAATTCATGATGTATTGGTAAAAATGCAAAAAGAGCGAACACATATCGCTATTCTTGTG
GATGAATATGGCGGCACTTCAGGTTTAGTCACTGCTGAAGATATTCTTGAAGAAATTGTCGGGGAAATCAGAGATGAATT
TGATAAAGATGAAGTGCCTAATATTAGAAAAGTAAATGATAATCACTATATCTTAGATTCGAAAGTGCTCATTGAAGATG
TAAATGATTTATTGGGAACGACGTTAGCAAGTGACGAAGTGGATACAATAGGCGGCTGGTTTATGACTCAACAAATAGAC
GCTGCAGTTGGGTCCGTTATAGAAGCCGATGGGTATATTTTTAAAGTGCACGAAACAGTTGGCCGGCATATTAATTATTT
AGAAATTGTCCGGAAAAAAGAATAA

Upstream 100 bases:

>100_bases
TTTAGGTTCTTTTGAACTTATAATGTTATATATACTGTTTTTTGTTTATTCAATAAATATTTACATCGGAGGTGTACGCC
TTACTAGGTAAGGCAAATCA

Downstream 100 bases:

>100_bases
CATCTGGATAAAACACATGAGATTTTGACTAATAAGATGCTTAAAGCCTGAGATGAAATTTTCATCCAGGCTTTTTTAAA
CAATGATCTTGCAGTTTAAG

Product: membrane associated protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKGAISAKKVITHLDEYLSACQLGITVTALGIGWVGEST
FEVILHPLFAHFHVSETVSHVLILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA
RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKEIMIPRREIVAISSEDSYETIVK
IIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDTDQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILV
DEYGGTSGLVTAEDILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGGWFMTQQID
AAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE

Sequences:

>Translated_434_residues
MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKGAISAKKVITHLDEYLSACQLGITVTALGIGWVGEST
FEVILHPLFAHFHVSETVSHVLILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA
RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKEIMIPRREIVAISSEDSYETIVK
IIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDTDQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILV
DEYGGTSGLVTAEDILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGGWFMTQQID
AAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE
>Mature_433_residues
TTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKGAISAKKVITHLDEYLSACQLGITVTALGIGWVGESTF
EVILHPLFAHFHVSETVSHVLILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSAR
FIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKEIMIPRREIVAISSEDSYETIVKI
IKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDTDQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVD
EYGGTSGLVTAEDILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGGWFMTQQIDA
AVGSVIEADGYIFKVHETVGRHINYLEIVRKKE

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI310128564, Length=399, Percent_Identity=47.3684210526316, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI1790664, Length=434, Percent_Identity=22.5806451612903, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI145693175, Length=381, Percent_Identity=23.3595800524934, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786879, Length=252, Percent_Identity=32.9365079365079, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI87082033, Length=238, Percent_Identity=23.9495798319328, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788119, Length=226, Percent_Identity=26.5486725663717, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539402, Length=257, Percent_Identity=26.0700389105058, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YRKA_BACSU (P54428)

Other databases:

- EMBL:   U93876
- EMBL:   AL009126
- EMBL:   D84432
- EMBL:   L32599
- PIR:   G69975
- RefSeq:   NP_390538.1
- ProteinModelPortal:   P54428
- SMR:   P54428
- EnsemblBacteria:   EBBACT00000002865
- GeneID:   937634
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU26610
- NMPDR:   fig|224308.1.peg.2663
- GenoList:   BSU26610
- GeneTree:   EBGT00070000031941
- HOGENOM:   HBG673071
- OMA:   GLAFMIM
- PhylomeDB:   P54428
- BioCyc:   BSUB:BSU26610-MONOMER
- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170
- Gene3D:   G3DSA:3.30.465.10
- SMART:   SM00116

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21

EC number: NA

Molecular weight: Translated: 48985; Mature: 48854

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS51371 CBS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10bacde0)-; HASH(0x10dba13c)-; HASH(0x10f5b30c)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKGAISAKKVITHLDEYLS
CCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVLILVIAFVMATFLHVVVGE
HHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSARFIVGLFGLKPASEHELAHS
HCCCCEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCC
EEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKEIMIPRREIVAISSEDSYETIVK
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCHHHHHHH
IIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDTDQKIKEDFKLENHINPVIHVIESV
HHHCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCC
PIHDVLVKMQKERTHIAILVDEYGGTSGLVTAEDILEEIVGEIRDEFDKDEVPNIRKVND
CHHHHHHHHHHCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCEEECC
NHYILDSKVLIEDVNDLLGTTLASDEVDTIGGWFMTQQIDAAVGSVIEADGYIFKVHETV
CEEEEECHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHEECCCEEEEEEHHH
GRHINYLEIVRKKE
CCCCCHHHHHHCCH
>Mature Secondary Structure 
TTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKGAISAKKVITHLDEYLS
CHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVLILVIAFVMATFLHVVVGE
HHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSARFIVGLFGLKPASEHELAHS
HCCCCEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCC
EEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKEIMIPRREIVAISSEDSYETIVK
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCHHHHHHH
IIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDTDQKIKEDFKLENHINPVIHVIESV
HHHCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCC
PIHDVLVKMQKERTHIAILVDEYGGTSGLVTAEDILEEIVGEIRDEFDKDEVPNIRKVND
CHHHHHHHHHHCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCEEECC
NHYILDSKVLIEDVNDLLGTTLASDEVDTIGGWFMTQQIDAAVGSVIEADGYIFKVHETV
CEEEEECHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHEECCCEEEEEEHHH
GRHINYLEIVRKKE
CCCCCHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059