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The map label for this gene is lysA

Identifier: 16079395

GI number: 16079395

Start: 2436947

End: 2438266

Strand: Reverse

Name: lysA

Synonym: BSU23380

Alternate gene names: 16079395

Gene position: 2438266-2436947 (Counterclockwise)

Preceding gene: 255767504

Following gene: 16079393

Centisome position: 57.84

GC content: 45.76

Gene sequence:

>1320_bases
TTGTTCTTACACGGCACAAGCAGACAAAATCAACATGGTCATTTAGAAATCGGAGGTGTGGATGCTCTCTATTTAGCGGA
GAAATATGGTACACCTCTTTACGTATATGATGTGGCTTTAATACGTGAGCGTGCTAAAAGCTTTAAGCAGGCGTTTATTT
CTGCAGGGCTGAAAGCACAGGTGGCATATGCGAGCAAAGCATTCTCATCAGTCGCAATGATTCAGCTCGCTGAGGAAGAG
GGACTTTCTTTAGATGTCGTATCCGGAGGAGAGCTATATACGGCTGTTGCAGCAGGCTTTCCGGCAGAACGCATCCACTT
TCATGGAAACAATAAGAGCAGGGAAGAACTGCGGATGGCGCTTGAGCACCGCATCGGCTGCATTGTGGTGGATAATTTCT
ATGAAATCGCGCTTCTTGAAGACCTATGTAAAGAAACGGGTCACTCCATCGATGTTCTTCTTCGGATCACGCCCGGAGTA
GAAGCGCATACGCATGACTACATTACAACGGGCCAGGAAGATTCAAAGTTTGGTTTCGATCTTCATAACGGACAAACTGA
ACGGGCCATTGAACAAGTATTACAATCGGAACACATTCAGCTGCTGGGTGTCCATTGCCATATCGGCTCGCAAATCTTTG
ATACGGCCGGTTTTGTGTTAGCAGCGGAAAAAATCTTCAAAAAACTAGACGAATGGAGAGATTCATATTCATTTGTATCC
AAGGTGCTGAATCTTGGAGGAGGTTTCGGCATTCGTTATACGGAAGATGATGAACCGCTTCATGCCACTGAATACGTTGA
AAAAATTATCGAAGCTGTGAAAGAAAATGCTTCCCGTTACGGTTTTGACATTCCGGAAATTTGGATCGAACCGGGCCGTT
CTCTCGTGGGAGACGCAGGCACAACTCTTTATACGGTTGGCTCTCAAAAAGAAGTGCCGGGTGTCCGCCAATATGTGGCT
GTAGACGGAGGCATGAACGACAATATTCGTCCTGCGCTTTACCAAGCTAAATATGAAGCTGCGGCAGCCAACAGGATCGG
AGAAGCGCATGACAAAACGGTATCAATTGCCGGAAAGTGCTGTGAAAGCGGAGATATGCTGATTTGGGATATTGACCTGC
CGGAAGTAAAAGAAGGCGATCTTCTTGCCGTTTTTTGTACAGGCGCTTATGGATACAGCATGGCCAACAATTATAACCGT
ATTCCGAGACCCGCCGTTGTATTTGTCGAAAACGGTGAGGCTCATTTAGTCGTGAAGCGAGAAACATACGAAGATATTGT
AAAACTTGATCTGCCATTTAAAACGGGTGTAAAGCAATAA

Upstream 100 bases:

>100_bases
TTGAAACTGACTGAAGAGTATGATAATGTATGTCTTAATTATGAAGGGACAGTCCATAAAACTGTCCTTTCATCCATAAG
CGGAGAAAGAGGGAATGACA

Downstream 100 bases:

>100_bases
AAGAAAGCGCCGATTTTTCGGCGCTTTTCTTATTTGAATATAGATACAATCGCATTCCAGATAGATACGAAGAAATCAAT
GACTTTCTGGATGAAGTTTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRERAKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEE
GLSLDVVSGGELYTAVAAGFPAERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGFVLAAEKIFKKLDEWRDSYSFVS
KVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKENASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVA
VDGGMNDNIRPALYQAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNR
IPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ

Sequences:

>Translated_439_residues
MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRERAKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEE
GLSLDVVSGGELYTAVAAGFPAERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGFVLAAEKIFKKLDEWRDSYSFVS
KVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKENASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVA
VDGGMNDNIRPALYQAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNR
IPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ
>Mature_439_residues
MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRERAKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEE
GLSLDVVSGGELYTAVAAGFPAERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGFVLAAEKIFKKLDEWRDSYSFVS
KVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKENASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVA
VDGGMNDNIRPALYQAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNR
IPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family

Homologues:

Organism=Escherichia coli, GI1789203, Length=422, Percent_Identity=33.4123222748815, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCDA_BACSU (P23630)

Other databases:

- EMBL:   X17013
- EMBL:   L09228
- EMBL:   D90189
- EMBL:   D84432
- EMBL:   AL009126
- PIR:   S45535
- RefSeq:   NP_390219.1
- ProteinModelPortal:   P23630
- SMR:   P23630
- EnsemblBacteria:   EBBACT00000002514
- GeneID:   938931
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU23380
- NMPDR:   fig|224308.1.peg.2343
- GenoList:   BSU23380
- GeneTree:   EBGT00050000002334
- HOGENOM:   HBG672375
- OMA:   HLICFAV
- ProtClustDB:   CLSK887517
- BioCyc:   BSUB:BSU23380-MONOMER
- BioCyc:   MetaCyc:MONOMER-6601
- BRENDA:   4.1.1.20
- ArrayExpress:   P23630
- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR01181
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01048

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.20

Molecular weight: Translated: 48574; Mature: 48574

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRERAKSFKQAFISAGLKAQ
CCCCCCCCCCCCCEEEECCCEEEEEHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEE
VAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPAERIHFHGNNKSREELRMA
HHHHHHHHHHHHEEEECCCCCCEEEEECCCCEEEHHHCCCCHHHEEECCCCCCHHHHHHH
LEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGVEAHTHDYITTGQEDSKFGFD
HHHCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCE
LHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGFVLAAEKIFKKLDEWRDSYSFVS
ECCCCHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKENASRYGFDIPEIWIEPGRSLVGDAG
HHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHCCCCC
TTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALYQAKYEAAAANRIGEAHDKTVSIAGKC
CEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHH
CESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNRIPRPAVVFVENGEAHLVVKR
CCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCCEEEEEECCCEEEEEEC
ETYEDIVKLDLPFKTGVKQ
CCHHHHHEECCCHHCCCCC
>Mature Secondary Structure
MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRERAKSFKQAFISAGLKAQ
CCCCCCCCCCCCCEEEECCCEEEEEHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEE
VAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPAERIHFHGNNKSREELRMA
HHHHHHHHHHHHEEEECCCCCCEEEEECCCCEEEHHHCCCCHHHEEECCCCCCHHHHHHH
LEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGVEAHTHDYITTGQEDSKFGFD
HHHCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCE
LHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGFVLAAEKIFKKLDEWRDSYSFVS
ECCCCHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKENASRYGFDIPEIWIEPGRSLVGDAG
HHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHCCCCC
TTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALYQAKYEAAAANRIGEAHDKTVSIAGKC
CEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHH
CESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNRIPRPAVVFVENGEAHLVVKR
CCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCCEEEEEECCCEEEEEEC
ETYEDIVKLDLPFKTGVKQ
CCHHHHHEECCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377