Definition Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
Accession NC_000964
Length 4,215,606

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The map label for this gene is aroB

Identifier: 16079327

GI number: 16079327

Start: 2378012

End: 2379100

Strand: Reverse

Name: aroB

Synonym: BSU22700

Alternate gene names: 16079327

Gene position: 2379100-2378012 (Counterclockwise)

Preceding gene: 255767489

Following gene: 16079326

Centisome position: 56.44

GC content: 44.81

Gene sequence:

>1089_bases
ATGAAGACACTGCATGTTCAAACTGCTTCCTCGTCATATCCTGTTTTTATCGGACAAGGTATCAGAAAAAAGGCTTGCGA
ACTATTAACCTCTTTAAACAGGCCTTTAACAAGGATTATGTTTGTCACGGATGAAGAAGTGGACCGCCTGTATGGTGATG
AAATGCTCCATTTGCTGCAAGAAAAATGGCCTGTGAAAAAAGTGACGGTACCGAGTGGAGAGCAGGCAAAATCCATGGAC
ATGTACACAAAATTGCAGAGTGAAGCGATTCGTTTTCATATGGATCGCTCCTCATGCATCATCGCATTCGGTGGCGGTGT
TGTAGGGGATCTTGCCGGTTTTGTGGCTGCCACTTTTATGCGCGGCATTGATTTCATCCAAATGCCTACGACGCTCTTGG
CGCATGACAGCGCAGTCGGAGGAAAAGTAGCCGTGAACCATCCGCTTGGAAAAAATCTAATCGGTGCGTTTTATCAGCCG
AAAGCCGTGCTCTATGATACAGATTTCCTGCGTTCTCTGCCTGAAAAAGAGCTTAGGTCCGGAATGGCAGAAGTGATTAA
ACACGCTTTTATCTATGACAGAGCGTTTCTGGAGGAGCTGCTGAATATCCACTCACTGCGTGATATCACTAATGATCAGC
TGAATGACATGATTTTTAAAGGCATTTCAATTAAAGCGTCTGTCGTTCAGCAGGATGAAAAAGAAGAGGGGATAAGAGCT
TACTTAAACTTTGGGCATACGCTCGGCCATGCCGTTGAGGCGGAATATGGATATGGGCAGATCACTCACGGTGATGCCGT
AGCCCTCGGAATGCAGTTTGCTTTATATATAAGCGAAAAGACTGTAGGCTGTGAAATGGACAGAAAACGTTTGGTCAGCT
GGCTAAAAAGCCTGGGTTATCCAAGTCAAATCAGAAAAGAGACGGAAACTTCGGTTCTCTTGAACCGTATGATGAATGAT
AAGAAAACCCGTGGCGGGAAGATTCAGTTTATTGTGCTCAACGAATTAGGGAAAGTTGCTGATCATACATTTTCCAGAAA
TGAACTTGAGAGCTGGCTGAACAAATGGCGATTGGAGGAGACATCATGA

Upstream 100 bases:

>100_bases
GGGAAATTGCGAACGCAGTCGTTGAACAATTCGGATTAGATCAAATTGACCGCATTAGAGAAAATGTGGAGAATATGAGA
AAACTGTCGAGGGAATTTTA

Downstream 100 bases:

>100_bases
TGATTCGCGGAATTCGCGGAGCAACTACAGTTGAACGGGATACTGAAGAAGAAATTTTACAAAAAACTAAACAGCTGTTA
GAGAAAATCATAGAAGAAAA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTDEEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMD
MYTKLQSEAIRFHMDRSSCIIAFGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP
KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMIFKGISIKASVVQQDEKEEGIRA
YLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALYISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMND
KKTRGGKIQFIVLNELGKVADHTFSRNELESWLNKWRLEETS

Sequences:

>Translated_362_residues
MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTDEEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMD
MYTKLQSEAIRFHMDRSSCIIAFGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP
KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMIFKGISIKASVVQQDEKEEGIRA
YLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALYISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMND
KKTRGGKIQFIVLNELGKVADHTFSRNELESWLNKWRLEETS
>Mature_362_residues
MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTDEEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMD
MYTKLQSEAIRFHMDRSSCIIAFGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP
KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMIFKGISIKASVVQQDEKEEGIRA
YLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALYISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMND
KKTRGGKIQFIVLNELGKVADHTFSRNELESWLNKWRLEETS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=348, Percent_Identity=42.5287356321839, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320332, Length=313, Percent_Identity=35.7827476038339, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_BACSU (P31102)

Other databases:

- EMBL:   M80245
- EMBL:   AL009126
- PIR:   G69589
- RefSeq:   NP_390151.1
- ProteinModelPortal:   P31102
- SMR:   P31102
- EnsemblBacteria:   EBBACT00000000923
- GeneID:   939001
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU22700
- NMPDR:   fig|224308.1.peg.2274
- GenoList:   BSU22700
- GeneTree:   EBGT00050000002325
- HOGENOM:   HBG632303
- OMA:   EHAIATS
- PhylomeDB:   P31102
- ProtClustDB:   PRK00002
- BioCyc:   BSUB:BSU22700-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 40818; Mature: 40818

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTDEEVDRLYGDEMLHLLQ
CCEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCHHEEEEECHHHHHHHHHHHHHHHHH
EKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIAFGGGVVGDLAGFVAATFM
HCCCCEEEECCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEECCCHHHHHHHHHHHHHH
RGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQPKAVLYDTDFLRSLPEKELRS
HCCHHHHCCHHHHHCCCCCCCEEEECCCCCHHHHHHHCCCCEEEEECHHHHHCCHHHHHH
GMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMIFKGISIKASVVQQDEKEEGIRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHCCHHHHHHHH
YLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALYISEKTVGCEMDRKRLVSWLKSLGY
HHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCC
PSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLNELGKVADHTFSRNELESWLNKWRLEE
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHCCCC
TS
CC
>Mature Secondary Structure
MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTDEEVDRLYGDEMLHLLQ
CCEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCHHEEEEECHHHHHHHHHHHHHHHHH
EKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIAFGGGVVGDLAGFVAATFM
HCCCCEEEECCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEECCCHHHHHHHHHHHHHH
RGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQPKAVLYDTDFLRSLPEKELRS
HCCHHHHCCHHHHHCCCCCCCEEEECCCCCHHHHHHHCCCCEEEEECHHHHHCCHHHHHH
GMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMIFKGISIKASVVQQDEKEEGIRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHCCHHHHHHHH
YLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALYISEKTVGCEMDRKRLVSWLKSLGY
HHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCC
PSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLNELGKVADHTFSRNELESWLNKWRLEE
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHCCCC
TS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377