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The map label for this gene is yngH

Identifier: 16078885

GI number: 16078885

Start: 1953181

End: 1954515

Strand: Reverse

Name: yngH

Synonym: BSU18240

Alternate gene names: 16078885

Gene position: 1954515-1953181 (Counterclockwise)

Preceding gene: 16078886

Following gene: 255767427

Centisome position: 46.36

GC content: 47.27

Gene sequence:

>1335_bases
ATGTTTACAAAAGTACTGATCGCCAACCGCGGTGAAATTGCAATGAGAATTATCCGAACATGCAGCCGTCTCGGCATTAA
AACGGTCGCTGTTTATTCAGAAGCAGACAAGGACGCGCCCCATACAAAAGCCGCTACAGAGGCATATTTGATCGGGGAAT
CGAGAGTCAGTGAAAGTTATTTAAATATAGAGAGAATCATAAAGACGGCGAAAAAAGCAAAAGCCGACGCGATCCACCCG
GGATATGGATTGTTATCAGAAAACAGCCGGTTCGCTGAACGCTGCAAGCAAGAAAACATCGTGTTTATCGGACCTTCCCC
TGATATCATCGCAAAGATGGGCAGCAAAATTGAAGCGCGAAAAGCAATGGAGGCTGCAGGTGTCCCTGTGGTGCCGGGCG
TTTCTGAATCCCTCGGAGATATAGAGGCAGCCTGCCGCACCGCAAGTCAAATCGGCTATCCTGTCATGCTGAAAGCTTCA
GCGGGCGGAGGCGGCATCGGAATGCAGCGTGTTGAAAATGAAGAAGCATTAAAAAAAGCGTACGAGGGAAACAAAAAGCG
CGCAGCAGATTTTTTCGGTGACGGGTCTATGTATATAGAAAAAGTTATTGAACATGCGCGCCACATCGAGGTTCAGCTTT
TGGCCGATCAACACGGCCATACAGTACATCTGTTTGAACGTGATTGCTCTGTTCAGAGGCGCCACCAAAAAGTCATTGAA
GAAGCACCGTCTCCATTTGTAGACGATGAACTAAGAATGAAGATCGGTCAAACAGCGGTAAAAGCAGCGAAGGCAATCGG
CTATACGAACGCAGGCACCATCGAATTTATAGTTGACCAGAAACAAAATTTTTATTTCCTCGAAATGAATACGAGACTGC
AAGTTGAACACCCCGTGACTGAAGAAATAACAGGCCTGGACTTAGTTGAGCAGCAGCTGCGGATTGCTGCGGGCCATACA
CTCACATTCTCCCAAAAAGACATCCAACGGAACGGGCATGCGATAGAGGTTCGAATATACGCGGAAGATCCCAAGACCTT
CTTCCCGTCACCAGGTACGATCACTGCGTTTTCACTTCCTGACCAAAAAGGAGTCAGACACGAATGTGCGGTAGCAAAAG
ACAGCACCGTTACCCCTTTTTATGACCCGATGATCGCTAAGATGATTGTCAAAGGCCAAACCAGAACAGAAGCAATTGAA
AAACTAGAGACAGCGCTTCGCGACTATCGTGTAGAGGGAATCAAAACAAACCTTCCGCTCCTCATACAGGCTGCGGCAAC
AAAGGCATTTAAAGAAGGGGATGTCACGACTGACTTTTTGAAACAGCACCTATAA

Upstream 100 bases:

>100_bases
TGACTATCCGATGACGGCCTCAGGCAAAATTCAAAAATATAAACTGCGAGAAAAAACGATTGAAATGTTCAACTTATCAT
CAAGTCAATGAGGTGAAATC

Downstream 100 bases:

>100_bases
AGGAGGCAGTTGTCATGACGGTTAGCATACAAATGGCAGGAAACCTGTGGAAAGTCCACGTCAAAGCCGGCGACCAAATC
GAAAAGGGCCAGGAGGTAGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 2; ACC 2

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKAATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHP
GYGLLSENSRFAERCKQENIVFIGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS
AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQHGHTVHLFERDCSVQRRHQKVIE
EAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEFIVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHT
LTFSQKDIQRNGHAIEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKGQTRTEAIE
KLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL

Sequences:

>Translated_444_residues
MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKAATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHP
GYGLLSENSRFAERCKQENIVFIGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS
AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQHGHTVHLFERDCSVQRRHQKVIE
EAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEFIVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHT
LTFSQKDIQRNGHAIEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKGQTRTEAIE
KLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL
>Mature_444_residues
MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKAATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHP
GYGLLSENSRFAERCKQENIVFIGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS
AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQHGHTVHLFERDCSVQRRHQKVIE
EAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEFIVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHT
LTFSQKDIQRNGHAIEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKGQTRTEAIE
KLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=52.2522522522522, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=49.3212669683258, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=49.3212669683258, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=49.3212669683258, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=45.7399103139013, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=45.7399103139013, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=45.7399103139013, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI38679960, Length=501, Percent_Identity=31.7365269461078, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679977, Length=501, Percent_Identity=31.7365269461078, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI38679967, Length=501, Percent_Identity=31.7365269461078, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI38679971, Length=501, Percent_Identity=31.7365269461078, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679974, Length=501, Percent_Identity=31.7365269461078, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI134142062, Length=500, Percent_Identity=31, Blast_Score=243, Evalue=2e-64,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=49.438202247191, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=47.2972972972973, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71987519, Length=443, Percent_Identity=49.2099322799097, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=48.2142857142857, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=31.211498973306, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71997168, Length=440, Percent_Identity=31.3636363636364, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=440, Percent_Identity=31.3636363636364, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=45.6179775280899, Blast_Score=402, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=43.9461883408072, Blast_Score=352, Evalue=5e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=44.3946188340807, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6323863, Length=434, Percent_Identity=33.8709677419355, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6324343, Length=509, Percent_Identity=31.6306483300589, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=47.9820627802691, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=46.0674157303371, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=47.4201474201474, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=31.1871227364185, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=31.1871227364185, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=31.1871227364185, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=31.1871227364185, Blast_Score=242, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACCC2_BACSU (O34544)

Other databases:

- EMBL:   Y13917
- EMBL:   AL009126
- PIR:   E69893
- RefSeq:   NP_389706.1
- HSSP:   P24182
- ProteinModelPortal:   O34544
- SMR:   O34544
- EnsemblBacteria:   EBBACT00000000111
- GeneID:   939474
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU18240
- NMPDR:   fig|224308.1.peg.1828
- GenoList:   BSU18240
- GeneTree:   EBGT00050000001329
- HOGENOM:   HBG535236
- OMA:   DPKTFFP
- ProtClustDB:   PRK06111
- BioCyc:   BSUB:BSU18240-MONOMER
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- SMART:   SM00878

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.3.4.14; =6.4.1.2

Molecular weight: Translated: 49088; Mature: 49088

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS50975 ATP_GRASP; PS50979 BC; PS00866 CPSASE_1; PS00867 CPSASE_2

Important sites: ACT_SITE 292-292 BINDING 116-116 BINDING 200-200 BINDING 235-235

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKAATEAYLIGESRVSESY
CCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHEEEECHHHHHHHH
LNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVFIGPSPDIIAKMGSKIEAR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHHCCHHHHH
KAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKASAGGGGIGMQRVENEEALKKA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHHHH
YEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQHGHTVHLFERDCSVQRRHQKVIE
HCCCCHHHHHHCCCCHHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEFIVDQKQNFYFLEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHAIEVRIYAEDPKTFFPSPGTITAFSLP
HHHCCHHHHHHHHHHHCCCEEEECHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEECC
DQKGVRHECAVAKDSTVTPFYDPMIAKMIVKGQTRTEAIEKLETALRDYRVEGIKTNLPL
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
LIQAAATKAFKEGDVTTDFLKQHL
EEEHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure
MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKAATEAYLIGESRVSESY
CCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHEEEECHHHHHHHH
LNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVFIGPSPDIIAKMGSKIEAR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHHCCHHHHH
KAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKASAGGGGIGMQRVENEEALKKA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHHHH
YEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQHGHTVHLFERDCSVQRRHQKVIE
HCCCCHHHHHHCCCCHHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEFIVDQKQNFYFLEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHAIEVRIYAEDPKTFFPSPGTITAFSLP
HHHCCHHHHHHHHHHHCCCEEEECHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEECC
DQKGVRHECAVAKDSTVTPFYDPMIAKMIVKGQTRTEAIEKLETALRDYRVEGIKTNLPL
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
LIQAAATKAFKEGDVTTDFLKQHL
EEEHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377