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The map label for this gene is mutL

Identifier: 16078768

GI number: 16078768

Start: 1778337

End: 1780220

Strand: Direct

Name: mutL

Synonym: BSU17050

Alternate gene names: 16078768

Gene position: 1778337-1780220 (Clockwise)

Preceding gene: 255767391

Following gene: 16078770

Centisome position: 42.18

GC content: 47.93

Gene sequence:

>1884_bases
GTGGCAAAAGTCATCCAACTGTCAGATGAGCTTTCAAATAAAATAGCGGCGGGCGAGGTTGTGGAACGGCCCGCCTCAGT
CGTCAAAGAATTGGTGGAAAATGCGATCGACGCTGACAGCACAGTCATTGAAATCGATATTGAGGAAGCAGGCCTTGCAT
CCATTCGGGTCTTGGATAACGGCGAAGGAATGGAGAATGAAGATTGCAAGCGAGCTTTCCGGCGCCACGCAACGAGTAAA
ATAAAAGATGAAAATGATTTATTCAGGGTGAGAACGCTCGGTTTCAGGGGAGAAGCCCTGCCGAGTATCGCGTCAGTCTC
TCATCTGGAGATTACAACAAGCACTGGTGAAGGAGCTGGGACGAAGCTCGTCCTCCAAGGAGGAAACATCATTTCCGAAT
CGCGTTCCTCAAGCAGGAAGGGAACTGAAATTGTCGTTTCCAACCTGTTTTTTAACACACCGGCCCGTTTGAAATATATG
AAAACCGTTCATACAGAGCTTGGAAACATTACAGATGTGGTTAACCGTATTGCTCTGGCGCATCCAGAGGTATCGATCCG
CCTGCGCCATCATGGGAAAAACCTGCTTCAAACGAACGGAAACGGAGATGTGCGCCATGTACTGGCAGCGATTTACGGCA
CGGCTGTCGCCAAAAAAATGCTTCCGCTGCATGTGAGCTCCTTGGATTTTGAAGTAAAGGGATATATCGCCCTCCCAGAG
ATTACACGGGCGTCGAGAAACTATATGTCGTCTGTGGTCAATGGCCGTTACATTAAAAATTTCCCGCTCGTCAAAGCGGT
TCATGAAGGCTATCATACGCTTCTGCCGATCGGACGCCATCCGATTACTTTTATAGAAATTACGATGGACCCGATTTTAG
TCGATGTCAACGTGCATCCATCGAAGCTTGAGGTCCGGCTCAGCAAGGAAACAGAGCTTCATGACTTAATACGTGACGGA
ATTAAAGATGTGTTTAAACAGCAGCAGCTGATTCCTAGTGCCCAGGTCCCGAAAAAATCAGCACCTGCCATCAAAAATGA
GCAGCAGTTTATAACCTTTGATGAAAAGCCTCCGGAAAAAAAAGTTCCGGAAAAATCGACTGCGCCATCTTATTCACCGA
TGAAGCTCAGCTCAGTCGTAAAAGAGCCGGTTGATGCGGAGGAAAAATTGCCCCCTCTCCAATTTGATGCTCCTCCTATC
GTTGATCAGGAACAAACCCTTGAGGTGTCCGATGTTTCAGCAGAACAGCCTGAAACATTTGAGCAGGAATGCCATGAGGA
ACAGCCGCAGCCAGCGTCTGATCGGGTTCCAATTATGTACCCGATTGGCCAGATGCACGGGACTTATATATTGGCACAAA
ACGAAAACGGCCTATATATTATCGACCAGCACGCCGCCCAAGAACGTATTAAATATGAGTACTTCCGTGAAAAGGTGGGG
GAGGTTGAGCCTGAGGTGCAGGAGATGATTGTACCGCTGACGTTCCACTACTCCACAAATGAGGCTTTGATTATTGAACA
GCACAAACAAGAGCTCGAAAGCGTCGGTGTCTTTTTAGAGTCATTCGGCTCTAACAGTTACATCGTCCGCTGCCACCCAG
CCTGGTTTCCAAAGGGAGAAGAAGCAGAGCTTATAGAAGAAATCATTCAGCAGGTGCTCGACTCCAAAAATATAGATATT
AAAAAACTTCGCGAGGAAGCGGCGATTATGATGAGCTGCAAAGGCTCCATCAAAGCAAATCGCCACCTCAGAAACGACGA
AATCAAAGCGCTTCTGGACGACCTCCGAAGCACATCAGACCCATTTACATGCCCGCACGGCCGCCCGATCATCATTCACC
ACTCGACATATGAGATGGAAAAGATGTTCAAACGCGTGATGTAG

Upstream 100 bases:

>100_bases
TGCTTTCAAATCACTTAATATACTGGATATGACACCGCTTGAAGCGATGAATGAAATGTACAAGCTGCAAAAGAAATTAC
ATTAAAACGGGGTGATGAAT

Downstream 100 bases:

>100_bases
CGGGGGTGGTAGGCATTGATCCATTCTCTGAATGGATCAATGCTTTTTTTGTACTCCTTCGAGTGTCAGATTATAAGAAA
CGGTTGTAAACGTGTGAGCA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIEIDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSK
IKDENDLFRVRTLGFRGEALPSIASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM
KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAKKMLPLHVSSLDFEVKGYIALPE
ITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLPIGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDG
IKDVFKQQQLIPSAQVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPPLQFDAPPI
VDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKYEYFREKVG
EVEPEVQEMIVPLTFHYSTNEALIIEQHKQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDI
KKLREEAAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFKRVM

Sequences:

>Translated_627_residues
MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIEIDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSK
IKDENDLFRVRTLGFRGEALPSIASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM
KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAKKMLPLHVSSLDFEVKGYIALPE
ITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLPIGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDG
IKDVFKQQQLIPSAQVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPPLQFDAPPI
VDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKYEYFREKVG
EVEPEVQEMIVPLTFHYSTNEALIIEQHKQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDI
KKLREEAAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFKRVM
>Mature_626_residues
AKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIEIDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKI
KDENDLFRVRTLGFRGEALPSIASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYMK
TVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAKKMLPLHVSSLDFEVKGYIALPEI
TRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLPIGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGI
KDVFKQQQLIPSAQVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPPLQFDAPPIV
DQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKYEYFREKVGE
VEPEVQEMIVPLTFHYSTNEALIIEQHKQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIK
KLREEAAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=353, Percent_Identity=32.2946175637394, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI4505911, Length=317, Percent_Identity=29.6529968454259, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI189458898, Length=317, Percent_Identity=29.6529968454259, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI4505913, Length=355, Percent_Identity=27.887323943662, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI310128478, Length=353, Percent_Identity=27.4787535410765, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI189458896, Length=308, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI91992160, Length=354, Percent_Identity=25.9887005649718, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI91992162, Length=354, Percent_Identity=25.9887005649718, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI263191589, Length=255, Percent_Identity=27.0588235294118, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI310128480, Length=307, Percent_Identity=25.0814332247557, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1790612, Length=568, Percent_Identity=31.1619718309859, Blast_Score=229, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=32.5, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17562796, Length=359, Percent_Identity=27.5766016713092, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=321, Percent_Identity=32.398753894081, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=388, Percent_Identity=28.8659793814433, Blast_Score=151, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325093, Length=714, Percent_Identity=21.4285714285714, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=340, Percent_Identity=24.7058823529412, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17136968, Length=328, Percent_Identity=33.5365853658537, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17136970, Length=346, Percent_Identity=28.9017341040462, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_BACSU (P49850)

Other databases:

- EMBL:   U27343
- EMBL:   AL009126
- PIR:   A69663
- RefSeq:   NP_389587.1
- PDB:   3GAB
- PDB:   3KDG
- PDB:   3KDK
- PDBsum:   3GAB
- PDBsum:   3KDG
- PDBsum:   3KDK
- ProteinModelPortal:   P49850
- EnsemblBacteria:   EBBACT00000001153
- GeneID:   939455
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU17050
- NMPDR:   fig|224308.1.peg.1708
- GenoList:   BSU17050
- GeneTree:   EBGT00050000002475
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   P49850
- ProtClustDB:   PRK00095
- BioCyc:   BSUB:BSU17050-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70432; Mature: 70301

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIEIDIEEAGLASIRVLDN
CCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEEC
GEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPSIASVSHLEITTSTGEGAG
CCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCCEEEEEEECCCCCCC
TKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYMKTVHTELGNITDVVNRIALA
CEEEEECCCEECCCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHC
HPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAKKMLPLHVSSLDFEVKGYIALPE
CCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEEEECCH
ITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLPIGRHPITFIEITMDPILVDVNVHP
HHHHHHHHHHHHHCCCEECCCHHHHHHHCCCHHCCCCCCCCEEEEEEEECEEEEEEECCC
SKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSAQVPKKSAPAIKNEQQFITFDEKPPEK
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
KVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPPLQFDAPPIVDQEQTLEVSDVSAEQPETF
CCCCCCCCCCCCCHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHH
EQECHEEQPQPASDRVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKYEYFREKVG
HHHHHHCCCCCCCCCCCEEEECCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHC
EVEPEVQEMIVPLTFHYSTNEALIIEQHKQELESVGVFLESFGSNSYIVRCHPAWFPKGE
CCCCCHHHEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
EAELIEEIIQQVLDSKNIDIKKLREEAAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSD
HHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCC
PFTCPHGRPIIIHHSTYEMEKMFKRVM
CCCCCCCCEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
AKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIEIDIEEAGLASIRVLDN
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEEC
GEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPSIASVSHLEITTSTGEGAG
CCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCCEEEEEEECCCCCCC
TKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYMKTVHTELGNITDVVNRIALA
CEEEEECCCEECCCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHC
HPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAKKMLPLHVSSLDFEVKGYIALPE
CCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEEEECCH
ITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLPIGRHPITFIEITMDPILVDVNVHP
HHHHHHHHHHHHHCCCEECCCHHHHHHHCCCHHCCCCCCCCEEEEEEEECEEEEEEECCC
SKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSAQVPKKSAPAIKNEQQFITFDEKPPEK
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
KVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPPLQFDAPPIVDQEQTLEVSDVSAEQPETF
CCCCCCCCCCCCCHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHH
EQECHEEQPQPASDRVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKYEYFREKVG
HHHHHHCCCCCCCCCCCEEEECCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHC
EVEPEVQEMIVPLTFHYSTNEALIIEQHKQELESVGVFLESFGSNSYIVRCHPAWFPKGE
CCCCCHHHEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
EAELIEEIIQQVLDSKNIDIKKLREEAAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSD
HHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCC
PFTCPHGRPIIIHHSTYEMEKMFKRVM
CCCCCCCCEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760914; 9384377