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The map label for this gene is uppS

Identifier: 16078716

GI number: 16078716

Start: 1721214

End: 1721996

Strand: Direct

Name: uppS

Synonym: BSU16530

Alternate gene names: 16078716

Gene position: 1721214-1721996 (Clockwise)

Preceding gene: 16078715

Following gene: 16078717

Centisome position: 40.83

GC content: 42.66

Gene sequence:

>783_bases
ATGCTCAACATACTCAAAAATTGGAAGAATCAGCAAACTGCGGCTTCCAACTTAGAACGTTATACAAAAGAAGACATACT
TAAGGGAGAAATTCCCGAACACATCGCCATTATCATGGATGGAAATGGCCGTTGGGCTAAAAAACGCTCTCTTCCCAGAA
TTGCAGGCCACCATGAAGGGATGAAGGTGGTAAAAAGGACCACGAAGCTCGCAAACGAATTAGGTGTCAAAGTACTGACA
TTGTATGCATTTTCAACAGAAAACTGGAAAAGACCGAAAATGGAGGTCGATTTTTTAATGAAGCTTCCGGAAGAATTTTT
GAATACGTATCTTCCAGAGCTTGTTGAGGAAAATGTACAGGTTCGGATCATTGGGGATGAAACGGCTTTGCCGGCGCACA
CATTACGTGCGATTGAAAAAGCTGTACAGGACACGGCGCAAAACGACGGAATGATCCTTAATTTTGCTCTTAACTATGGA
GGCCGTACTGAAATTGTCAGTGCTGCAAAATCACTCGCGGAAAAAGTGAAGGAAGGCTCTTTGAATATTGAAGACATTGA
TGAATCGCTTTTTTCTACTTATTTGATGACTGAATCTTTGCAGGATCCTGAACTTTTAATTCGAACGAGCGGCGAGATAA
GGCTGAGTAATTTTATGCTATGGCAGGTTGCCTACAGTGAATTTGTCTTTACTGACGTCTTGTGGCCTGACTTTAAAGAA
GATCACTTCTTGCAGGCGTTAGGAGAGTTTCAGCAGAGAGGCCGGAGGTTTGGCGGAATTTAG

Upstream 100 bases:

>100_bases
AAAGACCCTCTCATGTTTACAGGGGGTTTTTTTGTTAATACTGTTGATTACATTGATTATCAGCAGGGAATGTAACCTTT
TTGGGTGACGGAGGAATCTC

Downstream 100 bases:

>100_bases
AGGATGGTGGACATGAAACAAAGAATTTTGACAGGTGTTCTGGCAGCAATTGTATTTTTATTTTTGGTTATTGTCGGGAA
ATTGCCGTTCACCATATTAA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGRWAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLT
LYAFSTENWKRPKMEVDFLMKLPEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG
GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNFMLWQVAYSEFVFTDVLWPDFKE
DHFLQALGEFQQRGRRFGGI

Sequences:

>Translated_260_residues
MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGRWAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLT
LYAFSTENWKRPKMEVDFLMKLPEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG
GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNFMLWQVAYSEFVFTDVLWPDFKE
DHFLQALGEFQQRGRRFGGI
>Mature_260_residues
MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGRWAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLT
LYAFSTENWKRPKMEVDFLMKLPEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG
GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNFMLWQVAYSEFVFTDVLWPDFKE
DHFLQALGEFQQRGRRFGGI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=236, Percent_Identity=40.6779661016949, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI45580738, Length=236, Percent_Identity=40.6779661016949, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=49.5575221238938, Blast_Score=224, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=231, Percent_Identity=35.4978354978355, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=38.0281690140845, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=231, Percent_Identity=33.7662337662338, Blast_Score=126, Evalue=3e-30,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=36.6812227074236, Blast_Score=154, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_BACSU (O31751)

Other databases:

- EMBL:   AL009126
- PIR:   A69881
- RefSeq:   NP_389535.1
- ProteinModelPortal:   O31751
- SMR:   O31751
- EnsemblBacteria:   EBBACT00000002998
- GeneID:   939640
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU16530
- NMPDR:   fig|224308.1.peg.1656
- GenoList:   BSU16530
- GeneTree:   EBGT00050000002230
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   O31751
- ProtClustDB:   PRK14830
- BioCyc:   BSUB:BSU16530-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29778; Mature: 29778

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 40-40

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGRWAKKRSLPRIAGHHEG
CCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCCHHHCCHHH
MKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKLPEEFLNTYLPELVEENVQ
HHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCE
VRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYGGRTEIVSAAKSLAEKVKEGS
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
LNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNFMLWQVAYSEFVFTDVLWPDFKE
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCH
DHFLQALGEFQQRGRRFGGI
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGRWAKKRSLPRIAGHHEG
CCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCCHHHCCHHH
MKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKLPEEFLNTYLPELVEENVQ
HHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCE
VRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYGGRTEIVSAAKSLAEKVKEGS
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
LNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNFMLWQVAYSEFVFTDVLWPDFKE
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCH
DHFLQALGEFQQRGRRFGGI
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377