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The map label for this gene is ffh

Identifier: 16078661

GI number: 16078661

Start: 1672174

End: 1673514

Strand: Direct

Name: ffh

Synonym: BSU15980

Alternate gene names: 16078661

Gene position: 1672174-1673514 (Clockwise)

Preceding gene: 16078660

Following gene: 16078662

Centisome position: 39.67

GC content: 47.05

Gene sequence:

>1341_bases
ATGGCATTTGAAGGATTAGCCGACCGACTGCAGCAGACGATTTCTAAAATCCGCGGAAAAGGGAAAGTCAGCGAACAAGA
TGTAAAAGAGATGATGCGTGAGGTCCGTCTTGCGCTGCTTGAGGCTGACGTTAACTTTAAAGTAGTCAAGGATTTTGTCA
AAAAAGTAAGTGAACGCGCTGTAGGCCAAGACGTCATGAAAAGTCTGACGCCCGGCCAGCAGGTCATTAAAGTTGTTCAA
GAGGAACTGACTGAGCTGATGGGCGGCGAAGAGAGCAAAATCGCCGTCGCAAAAAGGCCGCCGACTGTTATTATGATGGT
CGGTCTCCAAGGTGCCGGTAAAACGACAACAAGCGGTAAGCTTGCGAATCTGCTGCGCAAAAAGCATAATCGCAAACCGA
TGCTGGTTGCTGCCGATATTTACCGCCCAGCCGCAATTAAGCAGCTGGAAACACTCGGCAAACAGCTTGATATGCCTGTT
TTCTCTCTTGGCGATCAGGTCAGTCCTGTAGAAATAGCTAAACAGGCTATTGAGAAAGCCAAGGAAGAACATTATGACTA
CGTCATTTTGGATACGGCAGGGCGCTTGCATATCGACCATGAACTGATGGATGAACTGACCAACGTCAAAGAAATCGCGA
ATCCGGAAGAAATTTTCCTGGTTGTCGATTCAATGACCGGTCAGGACGCTGTGAATGTTGCCAAAAGCTTTAATGAACAG
CTCGGTTTAACCGGTGTTGTGTTGACTAAGCTGGATGGAGACACACGCGGCGGGGCTGCGCTTTCTATTCGCGCTGTCAC
AAACACGCCAATTAAGTTTGCAGGTTTGGGCGAAAAGCTTGATGCGTTAGAGCCGTTCCATCCTGAACGCATGGCATCAA
GGATTCTCGGCATGGGCGACGTGCTGACATTGATTGAAAAAGCACAGGCCAGCGTTGATGAAGACAAAGCCAAAGAGCTG
GAACAAAAAATGAGAACGATGAGCTTCACATTGGACGATTTTCTGGAGCAGCTCGGGCAAGTCAGAAACATGGGGCCGCT
TGATGAGCTTCTGCAAATGATGCCGGGTGCAGGTAAAATGAAGGGCCTGAAAAACATCCAAGTTGATGAAAAACAGCTGA
ATCATGTGGAAGCAATCATCAAATCAATGACTGTTCTTGAAAAAGAACAGCCGGATATTATCAATGCCAGCCGGCGGAAG
CGGATTGCAAAAGGAAGCGGGACATCCGTACAGGAAGTCAACCGTCTGCTTAAGCAGTTTGATGAAATGAAAAAAATGAT
GAAGCAGATGACAAACATGTCAAAAGGCAAGAAAAAAGGGTTTAAGCTACCTTTTATGTAA

Upstream 100 bases:

>100_bases
TTTAATAAGCTGAAGGAGCTTGCTTCCGGTTCAAAAGAAGAGGAAGAAATTACAGCTCTGATTGAAGCGCTTGAGAAATT
AGATTAGGAGGCGGCAAACT

Downstream 100 bases:

>100_bases
TCGGTTATACATGATAAAACCGTTGTTAAGAAAAAACACTTTACAAACACTTTTATCATTGTTAATATACTATCTTGTTG
AAATATTTTCGGAGGTGCTA

Product: signal recognition particle-like (SRP) GTPase

Products: NA

Alternate protein names: Fifty-four homolog

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQ
EELTELMGGEESKIAVAKRPPTVIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV
FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEIFLVVDSMTGQDAVNVAKSFNEQ
LGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGLGEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKEL
EQKMRTMSFTLDDFLEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPDIINASRRK
RIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM

Sequences:

>Translated_446_residues
MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQ
EELTELMGGEESKIAVAKRPPTVIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV
FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEIFLVVDSMTGQDAVNVAKSFNEQ
LGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGLGEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKEL
EQKMRTMSFTLDDFLEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPDIINASRRK
RIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM
>Mature_445_residues
AFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQE
ELTELMGGEESKIAVAKRPPTVIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPVF
SLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEIFLVVDSMTGQDAVNVAKSFNEQL
GLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGLGEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELE
QKMRTMSFTLDDFLEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPDIINASRRKR
IAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=34.075723830735, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI226371618, Length=348, Percent_Identity=37.0689655172414, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI89061728, Length=142, Percent_Identity=40.1408450704225, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI23308697, Length=310, Percent_Identity=24.8387096774194, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI295424842, Length=310, Percent_Identity=24.8387096774194, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=54.2452830188679, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=35.4581673306773, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=441, Percent_Identity=30.6122448979592, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI193206261, Length=295, Percent_Identity=28.8135593220339, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=416, Percent_Identity=34.6153846153846, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=28.1645569620253, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17647949, Length=419, Percent_Identity=31.7422434367542, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24641198, Length=243, Percent_Identity=27.5720164609054, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_BACSU (P37105)

Other databases:

- EMBL:   D14356
- EMBL:   AL009126
- PIR:   B47154
- RefSeq:   NP_389480.1
- ProteinModelPortal:   P37105
- SMR:   P37105
- EnsemblBacteria:   EBBACT00000001545
- GeneID:   937104
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU15980
- NMPDR:   fig|224308.1.peg.1600
- GenoList:   BSU15980
- GeneTree:   EBGT00050000001995
- HOGENOM:   HBG562580
- OMA:   IINGSRR
- PhylomeDB:   P37105
- ProtClustDB:   PRK10867
- BioCyc:   BSUB:BSU15980-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- PANTHER:   PTHR11564:SF7
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963
- TIGRFAMs:   TIGR00959

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 49542; Mature: 49411

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERA
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPTVIMMVGLQGAGKTTTSGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCCHH
LANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPVFSLGDQVSPVEIAKQAIEKA
HHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEIFLVVDSMTGQDAVNVAKSFNEQ
HHHCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
LGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGLGEKLDALEPFHPERMASRILGMGD
CCCCEEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCHHHHCCCCCHHHHHHHHHCCHH
VLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDFLEQLGQVRNMGPLDELLQMMPGAGKM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
KGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPDIINASRRKRIAKGSGTSVQEVNRLLKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
DEMKKMMKQMTNMSKGKKKGFKLPFM
HHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERA
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPTVIMMVGLQGAGKTTTSGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCCHH
LANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPVFSLGDQVSPVEIAKQAIEKA
HHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEIFLVVDSMTGQDAVNVAKSFNEQ
HHHCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
LGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGLGEKLDALEPFHPERMASRILGMGD
CCCCEEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCHHHHCCCCCHHHHHHHHHCCHH
VLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDFLEQLGQVRNMGPLDELLQMMPGAGKM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
KGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPDIINASRRKRIAKGSGTSVQEVNRLLKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
DEMKKMMKQMTNMSKGKKKGFKLPFM
HHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896