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The map label for this gene is rnc

Identifier: 16078656

GI number: 16078656

Start: 1665710

End: 1666459

Strand: Direct

Name: rnc

Synonym: BSU15930

Alternate gene names: 16078656

Gene position: 1665710-1666459 (Clockwise)

Preceding gene: 16078655

Following gene: 255767364

Centisome position: 39.51

GC content: 41.73

Gene sequence:

>750_bases
ATGTCAAAACACTCACATTATAAAGATAAAAAAAAGTTCTATAAAAAAGTAGAACAATTTAAAGAGTTTCAAGAACGGAT
TTCGGTTCACTTTCAAAATGAAAAGCTTTTGTATCAAGCATTTACACATTCATCTTATGTGAATGAGCATCGGAAAAAGC
CGTATGAAGATAATGAAAGGCTTGAATTTTTAGGTGACGCTGTTTTGGAACTGACGATCTCCAGATTCTTATTTGCCAAA
TACCCGGCTATGAGTGAAGGAGATTTGACGAAATTGAGAGCCGCAATTGTTTGCGAACCGTCTCTCGTTTCATTGGCTCA
CGAGCTGTCATTCGGCGATCTTGTCCTGTTGGGTAAAGGCGAGGAAATGACAGGCGGAAGAAAGCGTCCTGCTCTATTGG
CGGATGTTTTTGAGGCATTTATCGGAGCCTTGTACCTTGACCAAGGATTAGAGCCGGTCGAAAGTTTCTTAAAAGTTTAT
GTGTTCCCTAAAATTAACGATGGTGCTTTTTCTCATGTGATGGATTTCAAAAGCCAGCTGCAGGAATACGTGCAGCGGGA
CGGCAAAGGCTCTCTGGAGTATAAAATCTCCAACGAAAAAGGACCTGCGCACAACCGTGAATTTGAAGCCATCGTATCTC
TAAAAGGTGAACCACTCGGAGTCGGAAACGGCCGTTCAAAGAAAGAAGCCGAACAGCACGCTGCTCAGGAAGCTTTAGCT
AAATTGCAAAAACACCATACGAAACAATAA

Upstream 100 bases:

>100_bases
CCTTTATTCGTGCAGTTATTACAGCATGCCGCTTTTACGCGCGCTGTATCCGGTTTAGTCAGAGAAGCGCGGTGAACCTG
ATGTGCCTATGGAGGTTACT

Downstream 100 bases:

>100_bases
AATCCCCCTTATGACTCAGGGGGATTTCAGTATGTATGCCGTCTTATTTGACCAATGTTTATGATAGAATTGAAATACTT
ATTACATAAGGAGGATCGCT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHSSYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAK
YPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY
VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEPLGVGNGRSKKEAEQHAAQEALA
KLQKHHTKQ

Sequences:

>Translated_249_residues
MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHSSYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAK
YPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY
VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEPLGVGNGRSKKEAEQHAAQEALA
KLQKHHTKQ
>Mature_248_residues
SKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHSSYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKY
PAMSEGDLTKLRAAIVCEPSLVSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVYV
FPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEPLGVGNGRSKKEAEQHAAQEALAK
LQKHHTKQ

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=236, Percent_Identity=34.7457627118644, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI155030234, Length=236, Percent_Identity=34.7457627118644, Blast_Score=120, Evalue=9e-28,
Organism=Escherichia coli, GI1788920, Length=227, Percent_Identity=35.6828193832599, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17506883, Length=236, Percent_Identity=33.4745762711864, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193202651, Length=236, Percent_Identity=33.4745762711864, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17552834, Length=167, Percent_Identity=32.3353293413174, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323895, Length=219, Percent_Identity=30.1369863013699, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137682, Length=234, Percent_Identity=31.1965811965812, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28426; Mature: 28294

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHSSYVNEHRKKPYEDNER
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
LEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGDLVLLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECC
EEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVYVFPKINDGAFSHVMDFKSQL
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEPLGVGNGRSKKEAEQHAAQEALA
HHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KLQKHHTKQ
HHHHHCCCC
>Mature Secondary Structure 
SKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHSSYVNEHRKKPYEDNER
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
LEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGDLVLLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECC
EEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVYVFPKINDGAFSHVMDFKSQL
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEPLGVGNGRSKKEAEQHAAQEALA
HHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KLQKHHTKQ
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA