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The map label for this gene is sipT

Identifier: 16078505

GI number: 16078505

Start: 1511308

End: 1511889

Strand: Direct

Name: sipT

Synonym: BSU14410

Alternate gene names: 16078505

Gene position: 1511308-1511889 (Clockwise)

Preceding gene: 16078504

Following gene: 16078507

Centisome position: 35.85

GC content: 41.92

Gene sequence:

>582_bases
TTGACCGAGGAAAAAAATACGAATACTGAGAAAACGGCGAAGAAAAAAACCAATACGTACCTGGAATGGGGTAAAGCGAT
TGTCATCGCTGTTCTGCTGGCTCTCCTGATCCGTCACTTTTTGTTTGAACCGTATTTAGTTGAAGGTTCATCTATGTATC
CCACATTACATGACGGAGAAAGGCTGTTTGTGAATAAAACAGTCAACTATATCGGCGAGCTGAAGCGCGGAGATATCGTT
ATTATCAACGGTGAAACTTCTAAAATCCATTATGTAAAAAGATTGATCGGAAAGCCTGGAGAAACCGTTCAAATGAAGGA
TGACACGCTTTATATAAACGGTAAAAAAGTAGCCGAGCCTTACTTGTCTAAAAACAAGAAGGAAGCAGAAAAACTTGGTG
TCAGTCTGACAGGAGACTTTGGACCGGTTAAGGTTCCGAAAGGCAAATACTTTGTCATGGGAGATAACCGGCTGAATTCT
ATGGACAGCCGAAACGGGCTGGGACTGATCGCGGAAGATCGAATTGTCGGCACATCGAAGTTTGTCTTTTTCCCGTTTAA
CGAAATGCGTCAAACAAAATAA

Upstream 100 bases:

>100_bases
GCCGGCAGGGAGCGCGGTTAAGTTATGTATTTTATTCTTTTTTATGATAAAGTAAAAGAAGAGAAACAACTGACATAGCA
ATTGTCTAGGAGGAAACACT

Downstream 100 bases:

>100_bases
AAACGCCTTGCTGGCCTAGGACAGCAGGCGTTTTTATTTTGAAAAAGAAGCGACCAATGCAATGCATAAAACCGTGATGA
ACACTGAACCGATAATAGCC

Product: type I signal peptidase

Products: NA

Alternate protein names: SPase I; Leader peptidase I

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEPYLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIV
IINGETSKIHYVKRLIGKPGETVQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS
MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK

Sequences:

>Translated_193_residues
MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEPYLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIV
IINGETSKIHYVKRLIGKPGETVQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS
MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK
>Mature_192_residues
TEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEPYLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVI
INGETSKIHYVKRLIGKPGETVQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNSM
DSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEPT_BACSU (P71013)

Other databases:

- EMBL:   U45883
- EMBL:   AF012285
- EMBL:   AL009126
- PIR:   G69707
- RefSeq:   NP_389324.1
- ProteinModelPortal:   P71013
- SMR:   P71013
- MEROPS:   S26.004
- EnsemblBacteria:   EBBACT00000002159
- GeneID:   938763
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU14410
- NMPDR:   fig|224308.1.peg.1443
- GenoList:   BSU14410
- GeneTree:   EBGT00070000031959
- HOGENOM:   HBG596607
- OMA:   KLVPQKF
- ProtClustDB:   CLSK862274
- BioCyc:   BSUB:BSU14410-MONOMER
- BRENDA:   3.4.21.89
- GO:   GO:0006508
- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- Gene3D:   G3DSA:2.10.109.10
- PRINTS:   PR00727
- TIGRFAMs:   TIGR02227

Pfam domain/function: PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.89

Molecular weight: Translated: 21855; Mature: 21723

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00501 SPASE_I_1; PS00760 SPASE_I_2; PS00761 SPASE_I_3

Important sites: ACT_SITE 51-51 ACT_SITE 93-93

Signals:

None

Transmembrane regions:

HASH(0xeb7c670)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEPYLVEGSSMYPTLHDGE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCC
RLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGETVQMKDDTLYINGKKVAEP
EEEEEHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEECCEEEECCHHHHCH
YLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNSMDSRNGLGLIAEDRIVGTSK
HHHCCHHHHHHCCCEEECCCCCEECCCCCEEEEECCCCCCCCCCCCCEEEECCCEECCCE
FVFFPFNEMRQTK
EEEECHHHHHCCH
>Mature Secondary Structure 
TEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEPYLVEGSSMYPTLHDGE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCC
RLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGETVQMKDDTLYINGKKVAEP
EEEEEHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEECCEEEECCHHHHCH
YLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNSMDSRNGLGLIAEDRIVGTSK
HHHCCHHHHHHCCCEEECCCCCEECCCCCEEEEECCCCCCCCCCCCCEEEECCCEECCCE
FVFFPFNEMRQTK
EEEECHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969500; 9384377; 9823656