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The map label for this gene is yjcI

Identifier: 16078252

GI number: 16078252

Start: 1258492

End: 1259613

Strand: Direct

Name: yjcI

Synonym: BSU11870

Alternate gene names: 16078252

Gene position: 1258492-1259613 (Clockwise)

Preceding gene: 255767267

Following gene: 16078253

Centisome position: 29.85

GC content: 47.95

Gene sequence:

>1122_bases
ATGTCACAGCACGTTGAAACGAAATTAGCTCAAATTGGGAACCGTAGCGATGAAGTCACGGGAACAGTGAGTGCTCCTAT
CTATTTATCAACAGCATACCGCCACAGAGGGATCGGAGAATCTACCGGATTTGATTATGTCCGCACAAAAAATCCGACAC
GCCAGCTTGTTGAGGACGCGATCGCTAACTTAGAAAACGGCGCGAGAGGGCTTGCCTTTAGTTCGGGAATGGCTGCTATC
CAAACGATTATGGCGCTGTTTAAAAGCGGAGATGAACTGATCGTTTCATCGGACCTATATGGCGGCACGTACCGTTTATT
TGAAAATGAATGGAAAAAATACGGATTGACTTTTCATTATGATGATTTCAGCGATGAGGACTGTTTACGCTCTAAGATTA
CGCCGAATACAAAAGCGGTGTTTGTGGAAACGCCGACAAACCCCCTCATGCAGGAGGCGGACATTGAACATATTGCCCGG
ATTACAAAGGAGCACGGTCTTCTGCTGATCGTAGATAATACATTTTATACACCGGTCTTGCAGCGGCCGCTTGAGCTGGG
AGCTGACATTGTCATTCACAGCGCAACCAAGTATTTAGGCGGGCATAACGATCTGCTTGCTGGACTTGTCGTGGTGAAGG
ATGAGCGGCTCGGAGAGGAAATGTTTCAGCATCAAAATGCAATCGGCGCCGTCCTGCCGCCATTTGATTCGTGGCTTCTG
ATGAGAGGAATGAAGACGCTGAGCCTCAGAATGCGCCAGCATCAGGCAAACGCGCAGGAGCTTGCGGCGTTTTTAGAAGA
GCAGGAAGAAATTTCGGATGTGCTGTATCCCGGAAAAGGCGGCATGCTGTCCTTCCGTCTGCAAAAAGAAGAATGGGTCA
ATCCGTTTTTAAAAGCACTGAAGACCATTTGTTTTGCAGAAAGCCTCGGCGGGGTGGAAAGCTTTATTACATACCCTGCG
ACCCAGACGCACATGGATATTCCTGAAGAGATCCGCATCGCAAACGGGGTGTGCAATCGGTTGCTGCGCTTTTCTGTCGG
TATTGAACATGCGGAAGATTTAAAAGAGGATCTAAAACAGGCATTATGTCAGGTCAAAGAGGGAGCTGTTTCATTTGAGT
AA

Upstream 100 bases:

>100_bases
CAGCAAGCGTTTTTTATGCTTGGAAGATAAGAAGAAGCGTTAAACCCCTTCTTCTTATGAAGAAGGGGTTTTTATTTTGA
AAAGGGAAGGTGTCAGCTAT

Downstream 100 bases:

>100_bases
ACACAATTGGACGCTGGAAACCCAGCTCGTGCACAATCCATTTAAAACAGACGGCGGAACCGGGGCAGTCAGTGTACCGA
TTCAGCACGCCTCGACTTTT

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CGS; O-acetylhomoserine (thiol)-lyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGFDYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAI
QTIMALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR
ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLL
MRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLYPGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPA
TQTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE

Sequences:

>Translated_373_residues
MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGFDYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAI
QTIMALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR
ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLL
MRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLYPGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPA
TQTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE
>Mature_372_residues
SQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGFDYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQ
TIMALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIARI
TKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLLM
RGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLYPGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPAT
QTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE

Specific function: Catalyzes the transformation of O-succinylhomoserine into cystathionine, as well as O-acetylhomoserine and sulfide into homocysteine

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family

Homologues:

Organism=Homo sapiens, GI21361334, Length=379, Percent_Identity=42.4802110817942, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI299473759, Length=379, Percent_Identity=38.2585751978892, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI25453487, Length=378, Percent_Identity=36.7724867724868, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1790375, Length=386, Percent_Identity=40.6735751295337, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1789383, Length=399, Percent_Identity=26.5664160401003, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17538055, Length=360, Percent_Identity=41.9444444444444, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17560056, Length=380, Percent_Identity=40, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI71980708, Length=390, Percent_Identity=34.1025641025641, Blast_Score=211, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6319307, Length=390, Percent_Identity=41.5384615384615, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6321254, Length=404, Percent_Identity=32.1782178217822, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6323333, Length=450, Percent_Identity=31.1111111111111, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6321904, Length=389, Percent_Identity=30.3341902313625, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321170, Length=278, Percent_Identity=32.3741007194245, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19922554, Length=378, Percent_Identity=41.7989417989418, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): METB_BACSU (O31631)

Other databases:

- EMBL:   AL009126
- PIR:   A69847
- RefSeq:   NP_389069.1
- HSSP:   P13254
- ProteinModelPortal:   O31631
- SMR:   O31631
- EnsemblBacteria:   EBBACT00000000679
- GeneID:   939812
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU11870
- NMPDR:   fig|224308.1.peg.1188
- GenoList:   BSU11870
- GeneTree:   EBGT00070000031827
- HOGENOM:   HBG754729
- OMA:   LEIRESY
- PhylomeDB:   O31631
- ProtClustDB:   PRK08247
- BioCyc:   BSUB:BSU11870-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11808
- PIRSF:   PIRSF001434

Pfam domain/function: PF01053 Cys_Met_Meta_PP; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.5.1.48; =2.5.1.49

Molecular weight: Translated: 41706; Mature: 41575

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGFDYVRTKNPTRQLVEDA
CCCHHHHHHHHHCCCCCCCEEEEECCEEEEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
IANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHY
HHHHCCCCCCCCHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEE
DDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIARITKEHGLLLIVDNTFYTPVL
CCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHH
QRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLL
HHHHHCCCCEEEEHHHHHHCCCHHHHHHHHEEECHHHHHHHHHHHCCCCCCCCCHHHHHH
MRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLYPGKGGMLSFRLQKEEWVNPFLKAL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHH
KTICFAESLGGVESFITYPATQTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQ
HHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ALCQVKEGAVSFE
HHHHHHCCCCCCC
>Mature Secondary Structure 
SQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGFDYVRTKNPTRQLVEDA
CCHHHHHHHHHCCCCCCCEEEEECCEEEEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
IANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHY
HHHHCCCCCCCCHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEE
DDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIARITKEHGLLLIVDNTFYTPVL
CCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHH
QRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLL
HHHHHCCCCEEEEHHHHHHCCCHHHHHHHHEEECHHHHHHHHHHHCCCCCCCCCHHHHHH
MRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLYPGKGGMLSFRLQKEEWVNPFLKAL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHH
KTICFAESLGGVESFITYPATQTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQ
HHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ALCQVKEGAVSFE
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377