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The map label for this gene is mecA

Identifier: 16078217

GI number: 16078217

Start: 1229068

End: 1229724

Strand: Direct

Name: mecA

Synonym: BSU11520

Alternate gene names: 16078217

Gene position: 1229068-1229724 (Clockwise)

Preceding gene: 16078215

Following gene: 16078218

Centisome position: 29.16

GC content: 40.03

Gene sequence:

>657_bases
ATGGAAATTGAAAGAATTAACGAGCATACAGTAAAATTTTATATGTCTTACGGAGATATTGAAGATCGCGGTTTTGACAG
AGAAGAAATTTGGTATAACCGTGAGCGCAGTGAAGAACTTTTCTGGGAAGTCATGGATGAAGTTCATGAAGAAGAGGAAT
TCGCTGTGGAAGGCCCACTTTGGATTCAAGTTCAGGCACTGGACAAAGGATTAGAAATCATCGTCACAAAAGCCCAGCTT
TCCAAAGACGGACAAAAGCTCGAACTGCCGATTCCTGAGGATAAAAAGCAAGAACCAGCATCTGAGGATCTTGACGCCTT
GCTGGATGATTTCCAGAAAGAAGAGCAAGCCGTCAATCAGGAAGAGAAGGAGCAAAAGCTTCAATTTGTCTTGCGATTTG
GCGATTTTGAGGATGTTATTTCTCTATCTAAATTGAACGTTAACGGAAGCAAAACGACTTTATATTCGTTTGAGAACCGA
TATTATTTATATGTAGATTTTTGCAATATGACTGATGAAGAGGTTGAAAATCAGCTAAGCATCCTGCTGGAGTACGCAAC
TGAATCCTCAATCAGCATACACCGTCTTGAAGAGTACGGCAAGCTGATTATTTCAGAGCATGCTCTAGAAACGATAAAAA
AACACTTTGCATCATAG

Upstream 100 bases:

>100_bases
AGGTTAAGATGTGGACGGAATGGGTAAAGTGTAGTAAAGTACAATTAATCGGGAGCTTAGATGTCCCTTCAACATCTTAT
ATAGAAGGGAAGGTTGGCAA

Downstream 100 bases:

>100_bases
CAAACCGATTTCCTTCCGGAAATCGGTTTTTTTTATGCACGAAAATGCCATTTTAGAGATGTGAAAAATCAAAAACATAT
AGACAAGCAGAAAATACAGC

Product: adaptor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEVMDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQL
SKDGQKLELPIPEDKKQEPASEDLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR
YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS

Sequences:

>Translated_218_residues
MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEVMDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQL
SKDGQKLELPIPEDKKQEPASEDLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR
YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS
>Mature_218_residues
MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEVMDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQL
SKDGQKLELPIPEDKKQEPASEDLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR
YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS

Specific function: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When ove

COG id: COG4862

COG function: function code OTN; Negative regulator of genetic competence, sporulation and motility

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mecA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MECA1_BACSU (P37958)

Other databases:

- EMBL:   L06059
- EMBL:   AL009126
- PIR:   S35289
- RefSeq:   NP_389034.1
- PDB:   3JTP
- PDBsum:   3JTP
- ProteinModelPortal:   P37958
- SMR:   P37958
- MINT:   MINT-2838776
- EnsemblBacteria:   EBBACT00000002282
- GeneID:   936406
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU11520
- NMPDR:   fig|224308.1.peg.1153
- GenoList:   BSU11520
- GeneTree:   EBGT00050000001420
- HOGENOM:   HBG491202
- OMA:   IHRLEEY
- ProtClustDB:   PRK02315
- BioCyc:   BSUB:BSU11520-MONOMER
- HAMAP:   MF_01124
- InterPro:   IPR008681
- PIRSF:   PIRSF029008

Pfam domain/function: PF05389 MecA

EC number: NA

Molecular weight: Translated: 25764; Mature: 25764

Theoretical pI: Translated: 4.12; Mature: 4.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEVMDEVHEEEEFAVEGPL
CCCCHHCCCEEEEEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHEEECCCE
WIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASEDLDALLDDFQKEEQAVNQ
EEEEEECCCCEEEEEEHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCH
EEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENRYYLYVDFCNMTDEEVENQLS
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCEEEEEEEECCCCHHHHHHHHH
ILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEVMDEVHEEEEFAVEGPL
CCCCHHCCCEEEEEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHEEECCCE
WIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASEDLDALLDDFQKEEQAVNQ
EEEEEECCCCEEEEEEHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCH
EEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENRYYLYVDFCNMTDEEVENQLS
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCEEEEEEEECCCCHHHHHHHHH
ILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412687; 9384377