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The map label for this gene is serC

Identifier: 16078066

GI number: 16078066

Start: 1075289

End: 1076368

Strand: Reverse

Name: serC

Synonym: BSU10020

Alternate gene names: 16078066

Gene position: 1076368-1075289 (Counterclockwise)

Preceding gene: 16078067

Following gene: 255767234

Centisome position: 25.53

GC content: 45.46

Gene sequence:

>1080_bases
ATGGAACGTACAACGAATTTTAACGCAGGTCCTGCAGCGCTGCCACTGGAAGTTCTGCAAAAAGCACAGAAAGAATTTAT
TGATTTTAACGAATCCGGCATGTCTGTTATGGAGCTTTCCCACCGCAGCAAAGAGTATGAAGCGGTGCACCAAAAAGCGA
AAAGCCTCTTAATCGAACTGATGGGCATTCCGGAAGATTACGATATCTTGTTTCTTCAAGGCGGGGCAAGCCTTCAATTC
TCAATGCTTCCGATGAACTTTTTAACACCTGAAAAAACCGCACATTTTGTGATGACCGGCGCTTGGTCTGAAAAAGCACT
GGCAGAAACGAAACTGTTCGGGAACACGTCTATCACCGCTACAAGTGAAACAGACAATTACAGTTATATTCCAGAGGTTG
ACCTTACGGATGTAAAAGACGGCGCATATTTACATATCACATCCAACAATACAATTTTCGGCACTCAGTGGCAGGAGTTT
CCGAATTCTCCAATTCCGCTCGTAGCCGACATGTCCAGCGATATTTTAAGCAGAAAAATCGATGTGTCCAAATTTGATGT
GATCTACGGAGGCGCCCAAAAGAACCTCGGCCCTTCCGGCGTGACTGTAGTCATCATGAAAAAAAGCTGGCTGCAAAATG
AAAATGCGAACGTCCCAAAAATCTTGAAATATTCCACGCATGTCAAAGCGGATTCACTCTACAACACTCCGCCGACATTT
GCGATTTATATGCTGAGCCTCGTTCTGGAATGGCTCAAGGAAAACGGCGGTGTGGAAGCTGTTGAACAGCGCAATGAACA
AAAAGCGCAGGTTCTCTACAGCTGTATTGATGAAAGCAACGGCTTCTATAAAGGACATGCCAGAAAAGACAGCCGCTCAC
GCATGAATGTCACATTCACGCTTCGGGATGACGAATTAACGAAAACATTCGTTCAGAAAGCAAAAGATGCGAAGATGATC
GGCCTTGGCGGACACCGTTCGGTGGGAGGCTGCCGCGCTTCTATTTATAACGCGGTCTCTCTCGAAGACTGTGAAAAATT
AGCTGCGTTCATGAAGAAATTCCAGCAGGAAAATGAGTAA

Upstream 100 bases:

>100_bases
TTCTTTTGATAATTCTAATTTTTTATCAAAAAACTGAATTTTTGTGATAGGATAATTGTATTATTTTATACATTAACGTG
GAAAACAGGGAGAGATCATA

Downstream 100 bases:

>100_bases
AAAGTCTGGCTATGCAAACCGTCCGTTTGGTATACTGTTTGCATAACACATTCTGTAAAGCCTTCGCAATAAATGATGAG
CATATTATTGGAGGGCAAAA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT; Vegetative protein 234; VEG234

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSKEYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQF
SMLPMNFLTPEKTAHFVMTGAWSEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF
PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANVPKILKYSTHVKADSLYNTPPTF
AIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCIDESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMI
GLGGHRSVGGCRASIYNAVSLEDCEKLAAFMKKFQQENE

Sequences:

>Translated_359_residues
MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSKEYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQF
SMLPMNFLTPEKTAHFVMTGAWSEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF
PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANVPKILKYSTHVKADSLYNTPPTF
AIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCIDESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMI
GLGGHRSVGGCRASIYNAVSLEDCEKLAAFMKKFQQENE
>Mature_359_residues
MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSKEYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQF
SMLPMNFLTPEKTAHFVMTGAWSEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF
PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANVPKILKYSTHVKADSLYNTPPTF
AIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCIDESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMI
GLGGHRSVGGCRASIYNAVSLEDCEKLAAFMKKFQQENE

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=366, Percent_Identity=43.7158469945355, Blast_Score=314, Evalue=8e-86,
Organism=Homo sapiens, GI10863955, Length=362, Percent_Identity=39.5027624309392, Blast_Score=265, Evalue=4e-71,
Organism=Escherichia coli, GI1787136, Length=364, Percent_Identity=43.4065934065934, Blast_Score=295, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17506897, Length=364, Percent_Identity=42.5824175824176, Blast_Score=296, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6324758, Length=389, Percent_Identity=39.3316195372751, Blast_Score=272, Evalue=5e-74,
Organism=Drosophila melanogaster, GI21356589, Length=361, Percent_Identity=42.9362880886427, Blast_Score=301, Evalue=5e-82,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_BACSU (P80862)

Other databases:

- EMBL:   Y14077
- EMBL:   AL009126
- PIR:   D69705
- RefSeq:   NP_388883.1
- ProteinModelPortal:   P80862
- SMR:   P80862
- EnsemblBacteria:   EBBACT00000003828
- GeneID:   936304
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU10020
- NMPDR:   fig|224308.1.peg.1002
- GenoList:   BSU10020
- GeneTree:   EBGT00050000002587
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- PhylomeDB:   P80862
- ProtClustDB:   PRK05355
- BioCyc:   BSUB:BSU10020-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40136; Mature: 40136

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 151-151 BINDING 170-170 BINDING 193-193

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSKEYEAVHQKAKSLLIEL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
MGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAWSEKALAETKLFGNTSITA
HCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEE
TSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEFPNSPIPLVADMSSDILSRKI
ECCCCCCEECCCCCCCCCCCCEEEEEECCCEEECCCHHHCCCCCCCEEECCHHHHHHHCC
DVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANVPKILKYSTHVKADSLYNTPPTF
CCCCEEEEECCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHH
AIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCIDESNGFYKGHARKDSRSRMNVTFT
HHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEE
LRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRASIYNAVSLEDCEKLAAFMKKFQQENE
EECHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSKEYEAVHQKAKSLLIEL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
MGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAWSEKALAETKLFGNTSITA
HCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEE
TSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEFPNSPIPLVADMSSDILSRKI
ECCCCCCEECCCCCCCCCCCCEEEEEECCCEEECCCHHHCCCCCCCEEECCHHHHHHHCC
DVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANVPKILKYSTHVKADSLYNTPPTF
CCCCEEEEECCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHH
AIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCIDESNGFYKGHARKDSRSRMNVTFT
HHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEE
LRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRASIYNAVSLEDCEKLAAFMKKFQQENE
EECHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659