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The map label for this gene is dck

Identifier: 16077082

GI number: 16077082

Start: 22496

End: 23149

Strand: Reverse

Name: dck

Synonym: BSU00140

Alternate gene names: 16077082

Gene position: 23149-22496 (Counterclockwise)

Preceding gene: 16077083

Following gene: 16077076

Centisome position: 0.55

GC content: 37.61

Gene sequence:

>654_bases
ATGAAGGAACATCATATCCCTAAGAATTCAATTATTACAGTAGCAGGAACAGTAGGTGTCGGAAAATCGACTTTAACAAA
AACTTTAGCTAAACGGCTTGGATTTAAAACATCGTTGGAGGAAGTCGATCATAATCCATATTTGGAAAAGTTCTATCATG
ATTTTGAACGTTGGAGCTTTCACCTTCAAATTTACTTCTTAGCTGAACGCTTCAAAGAACAGAAAACAATTTTTGAAGCC
GGCGGAGGTTTTGTACAGGATCGTTCGATTTATGAAGATACAGGAATTTTCGCAAAAATGCATGCTGATAAAGGGACAAT
GTCAAAGGTTGATTATAAGACTTACACAAGCCTTTTCGAAGCAATGGTAATGACACCGTATTTCCCACATCCAGATGTGT
TGATCTATTTAGAAGGAGATCTGGAGAACATTTTAAACCGGATTGAACAACGCGGCCGTGAGATGGAGCTTCAGACAAGC
CGGTCTTATTGGGAAGAAATGCATACACGCTACGAGAACTGGATAAGCGGTTTTAATGCCTGCCCTGTTTTAAAACTTCG
CATTGAAGATTATGATCTTCTGAACGACGAAAACTCGATTGAAAATATTGTAGATCAAATTGCTTCAGTTATTCATGATA
ATCAAAAAAAGTGA

Upstream 100 bases:

>100_bases
CTGAACTTACAGTGTTAACCGTAGATGGTGATTCAAAGGATTTCGTTTTGAATAAGAGCGACTTTGAACGCATTGCCGCC
CATGTAAAGGAGCTTATCGT

Downstream 100 bases:

>100_bases
ATCTCAGTCGAGATTCACTTTTTCTTTAAAATAAAAAATCCGCCGCACCGAATGCAACGGACAAAACAATCTCCAATATA
TGCTTGTGTTTCATTAGAAT

Product: deoxyadenosine/deoxycytidine kinase

Products: NA

Alternate protein names: dAK/dCK

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDHNPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEA
GGGFVQDRSIYEDTGIFAKMHADKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS
RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK

Sequences:

>Translated_217_residues
MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDHNPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEA
GGGFVQDRSIYEDTGIFAKMHADKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS
RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK
>Mature_217_residues
MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDHNPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEA
GGGFVQDRSIYEDTGIFAKMHADKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS
RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK

Specific function: Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the n

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family

Homologues:

Organism=Homo sapiens, GI290656975, Length=194, Percent_Identity=28.8659793814433, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI290656936, Length=194, Percent_Identity=28.8659793814433, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCK_BACSU (P37529)

Other databases:

- EMBL:   D26185
- EMBL:   AL009126
- PIR:   S66044
- RefSeq:   NP_387895.1
- ProteinModelPortal:   P37529
- SMR:   P37529
- EnsemblBacteria:   EBBACT00000003435
- GeneID:   936793
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU00140
- NMPDR:   fig|224308.1.peg.14
- GenoList:   BSU00140
- GeneTree:   EBGT00050000000907
- HOGENOM:   HBG725501
- OMA:   FFLNKRF
- ProtClustDB:   CLSK884721
- BioCyc:   BSUB:BSU00140-MONOMER
- InterPro:   IPR002624
- PANTHER:   PTHR10513

Pfam domain/function: PF01712 dNK

EC number: =2.7.1.74; =2.7.1.76

Molecular weight: Translated: 25444; Mature: 25444

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: ACT_SITE 87-87 BINDING 40-40 BINDING 52-52 BINDING 63-63 BINDING 88-88 BINDING 93-93 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDHNPYLEKFYHDFERWSF
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHEE
HLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHADKGTMSKVDYKTYTSLFE
HEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
AMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTSRSYWEEMHTRYENWISGFNA
HHHHCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
CPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDHNPYLEKFYHDFERWSF
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHEE
HLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHADKGTMSKVDYKTYTSLFE
HEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
AMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTSRSYWEEMHTRYENWISGFNA
HHHHCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
CPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377