Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 159901446

GI number: 159901446

Start: 6265044

End: 6265700

Strand: Direct

Name: adk [H]

Synonym: Haur_4935

Alternate gene names: 159901446

Gene position: 6265044-6265700 (Clockwise)

Preceding gene: 159901445

Following gene: 159901447

Centisome position: 98.72

GC content: 49.92

Gene sequence:

>657_bases
ATGAACATCATTTTGCTTGGTTCGCCTGGAGCGGGCAAAGGAACCCAGGCAACTGAGTTGGAAGCAGCAACCGGCATGAA
GCATATTGCCAGCGGCGATATGTTTCGGGCGGCTGTGCGTGAAGGCACACCACTGGGCAAACTCGCCCAATCGTATCTCG
ATAAAGGCGAGCTTGTGCCCGATGATGTTGTGATTGGCATGGTTTTGGAACGGGTACGCCAACCCGATTGTGAAAATGGG
GTGATTTTCGATGGGTTTCCACGAACGCCTCAACAAGCCGAAGCCCTGCAAGCAGCCCTAGCTGAACATAACGATGCGAT
CAACGCCGTGTTGTTGCTGCATGTCGATAAAGATGTGTTGATTCAACGGGTGATTGGGCGCTGGACTTGCAGAAAATGTC
AAGCTGTATATAATACATACTTCCGAGCACCAAAAGTCGAGGGTGTTTGTGATCTCTGCGAAGGCGATTTGTACCAACGC
AGCGATGACAACCTTGAGACGATCAACCATCGACTTGATGTTTACGAAGCCCAAACATCGCCATTAATTGCCCATTATCG
CACGCAAGGAATCTTGCACGAAATTGATGGCCTTGGCGATATCGACGATATTACTGCACGCATGGTTCAAGCAATTGAAT
CGGCAAAGCCGTGCTAA

Upstream 100 bases:

>100_bases
TCATCTCGCGCTAAGAAACGCTAACTGCTGTGGGCAGGCGGCGCTATGGCGAACAACGGCGTTCGCCATCCTTTGCTGAC
TCACCGAGGAGCACTGACCT

Downstream 100 bases:

>100_bases
ATTTGTGGTATAGTAATAGGTACCGATGCAGAAGCATGGGCCGACGGCCTATGCTTCTAGCTTGCTGCGTATGCTATACA
CCGTCTGCTGGCGTATTGCA

Product: nucleoside-triphosphate--adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MNIILLGSPGAGKGTQATELEAATGMKHIASGDMFRAAVREGTPLGKLAQSYLDKGELVPDDVVIGMVLERVRQPDCENG
VIFDGFPRTPQQAEALQAALAEHNDAINAVLLLHVDKDVLIQRVIGRWTCRKCQAVYNTYFRAPKVEGVCDLCEGDLYQR
SDDNLETINHRLDVYEAQTSPLIAHYRTQGILHEIDGLGDIDDITARMVQAIESAKPC

Sequences:

>Translated_218_residues
MNIILLGSPGAGKGTQATELEAATGMKHIASGDMFRAAVREGTPLGKLAQSYLDKGELVPDDVVIGMVLERVRQPDCENG
VIFDGFPRTPQQAEALQAALAEHNDAINAVLLLHVDKDVLIQRVIGRWTCRKCQAVYNTYFRAPKVEGVCDLCEGDLYQR
SDDNLETINHRLDVYEAQTSPLIAHYRTQGILHEIDGLGDIDDITARMVQAIESAKPC
>Mature_218_residues
MNIILLGSPGAGKGTQATELEAATGMKHIASGDMFRAAVREGTPLGKLAQSYLDKGELVPDDVVIGMVLERVRQPDCENG
VIFDGFPRTPQQAEALQAALAEHNDAINAVLLLHVDKDVLIQRVIGRWTCRKCQAVYNTYFRAPKVEGVCDLCEGDLYQR
SDDNLETINHRLDVYEAQTSPLIAHYRTQGILHEIDGLGDIDDITARMVQAIESAKPC

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=212, Percent_Identity=38.2075471698113, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI7524346, Length=212, Percent_Identity=38.2075471698113, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=37.5634517766497, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=31.9796954314721, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=31.9796954314721, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=31.9796954314721, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=31.9796954314721, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI4502011, Length=217, Percent_Identity=29.0322580645161, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=24.4239631336406, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI28144897, Length=213, Percent_Identity=26.2910798122066, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI28144899, Length=213, Percent_Identity=26.2910798122066, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI22749187, Length=178, Percent_Identity=26.9662921348315, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786680, Length=189, Percent_Identity=43.9153439153439, Blast_Score=159, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=35.377358490566, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=28.3720930232558, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=191, Percent_Identity=32.9842931937173, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=214, Percent_Identity=23.8317757009346, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=24.1860465116279, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=39.5939086294416, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321018, Length=207, Percent_Identity=32.8502415458937, Blast_Score=122, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=24.0740740740741, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI22026816, Length=218, Percent_Identity=35.3211009174312, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17737899, Length=194, Percent_Identity=38.1443298969072, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24645822, Length=194, Percent_Identity=38.1443298969072, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24663208, Length=212, Percent_Identity=27.8301886792453, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647141, Length=212, Percent_Identity=27.8301886792453, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221459597, Length=203, Percent_Identity=26.1083743842365, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356893, Length=203, Percent_Identity=26.1083743842365, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR001878 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23900; Mature: 23900

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILLGSPGAGKGTQATELEAATGMKHIASGDMFRAAVREGTPLGKLAQSYLDKGELVP
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DDVVIGMVLERVRQPDCENGVIFDGFPRTPQQAEALQAALAEHNDAINAVLLLHVDKDVL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHH
IQRVIGRWTCRKCQAVYNTYFRAPKVEGVCDLCEGDLYQRSDDNLETINHRLDVYEAQTS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCC
PLIAHYRTQGILHEIDGLGDIDDITARMVQAIESAKPC
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIILLGSPGAGKGTQATELEAATGMKHIASGDMFRAAVREGTPLGKLAQSYLDKGELVP
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DDVVIGMVLERVRQPDCENGVIFDGFPRTPQQAEALQAALAEHNDAINAVLLLHVDKDVL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHH
IQRVIGRWTCRKCQAVYNTYFRAPKVEGVCDLCEGDLYQRSDDNLETINHRLDVYEAQTS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCC
PLIAHYRTQGILHEIDGLGDIDDITARMVQAIESAKPC
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA