Click here to switch to the map view.

The map label for this gene is dck [H]

Identifier: 159901405

GI number: 159901405

Start: 6230750

End: 6231430

Strand: Reverse

Name: dck [H]

Synonym: Haur_4894

Alternate gene names: 159901405

Gene position: 6231430-6230750 (Counterclockwise)

Preceding gene: 159901406

Following gene: 159901399

Centisome position: 98.19

GC content: 49.63

Gene sequence:

>681_bases
ATGGGACATACATTTTTCGGCCAGCACTTATATTTGAGTGTGGCGGGCAATATTGGGGTGGGCAAAAGCACCCTCGTCGA
AACTTTAGCCGCCGCCTTTGGCTGGCAGCCCTACTACGAATTTGTGGCCGATCATCCCTATCTCGATGATTTTTATGCCG
ATAAACATCGCTGGGGCTTTCATTCGCAAATGTGGTTTTTGGCCCAGCGCTTCGAGCAACAACGCGAAATTGCCGATACG
CCGATCTCATTAATTCAAGATCGCTCGATTTATGAAGATTATGAGGTGTTTGCCAAGGGTTTGTTGGAGCAGGGGATTAT
GAGCCATCGCGATTTTCGCACCTATCGCAAACTCTACCAAGCGCTGATTCAATCGACTACCCCGCCAACCTTGATGGTCT
ATCTGCGCGGCTCGGTTCCCACGTTATTGGAGCGCATCAAAAAACGCGCTCGGCCAAGCGAGATGAATATTAGTGCCGAT
TATTTGAGCCATCTGAACAATCGGTATGATGAATGGCTCCGCCGTTTCGAGTTATGTCCAGTGCTTACAATCGAAACTGA
CGATCTGGATGTGGTCAATCGCGACGACCATCGCCAGCAAGTGATTGAAATCATCGGTCAGGCGGTGGGCCGACGCAGCA
ATTTTCAATATCGCTTGCCACTCAATGGCGATAAAGCCTAG

Upstream 100 bases:

>100_bases
CTTTGCTCTATGTTCTTTTGCCTTCTGCCTTTTGATTTTTGACTTTATAATGGATTGGTTGCAGAACAACGATTCGCCTG
GTAACAAGGATTGAAGCACA

Downstream 100 bases:

>100_bases
CTTATGTAGCCCAAGTCTCAACGGAAACTTGGGCTTAATCTTAGCCCTCAACCCGCACGGTGATGGTTGTACCCGCTTGA
GGTTGCGATTGAACTTCAAA

Product: deoxynucleoside kinase

Products: NA

Alternate protein names: dAK/dCK [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MGHTFFGQHLYLSVAGNIGVGKSTLVETLAAAFGWQPYYEFVADHPYLDDFYADKHRWGFHSQMWFLAQRFEQQREIADT
PISLIQDRSIYEDYEVFAKGLLEQGIMSHRDFRTYRKLYQALIQSTTPPTLMVYLRGSVPTLLERIKKRARPSEMNISAD
YLSHLNNRYDEWLRRFELCPVLTIETDDLDVVNRDDHRQQVIEIIGQAVGRRSNFQYRLPLNGDKA

Sequences:

>Translated_226_residues
MGHTFFGQHLYLSVAGNIGVGKSTLVETLAAAFGWQPYYEFVADHPYLDDFYADKHRWGFHSQMWFLAQRFEQQREIADT
PISLIQDRSIYEDYEVFAKGLLEQGIMSHRDFRTYRKLYQALIQSTTPPTLMVYLRGSVPTLLERIKKRARPSEMNISAD
YLSHLNNRYDEWLRRFELCPVLTIETDDLDVVNRDDHRQQVIEIIGQAVGRRSNFQYRLPLNGDKA
>Mature_225_residues
GHTFFGQHLYLSVAGNIGVGKSTLVETLAAAFGWQPYYEFVADHPYLDDFYADKHRWGFHSQMWFLAQRFEQQREIADTP
ISLIQDRSIYEDYEVFAKGLLEQGIMSHRDFRTYRKLYQALIQSTTPPTLMVYLRGSVPTLLERIKKRARPSEMNISADY
LSHLNNRYDEWLRRFELCPVLTIETDDLDVVNRDDHRQQVIEIIGQAVGRRSNFQYRLPLNGDKA

Specific function: Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the n

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family [H]

Homologues:

Organism=Homo sapiens, GI290656975, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI18426967, Length=231, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI290656936, Length=203, Percent_Identity=26.1083743842365, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4758768, Length=198, Percent_Identity=26.2626262626263, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI290657203, Length=197, Percent_Identity=25.3807106598985, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002624 [H]

Pfam domain/function: PF01712 dNK [H]

EC number: =2.7.1.74; =2.7.1.76 [H]

Molecular weight: Translated: 26515; Mature: 26384

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHTFFGQHLYLSVAGNIGVGKSTLVETLAAAFGWQPYYEFVADHPYLDDFYADKHRWGF
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHCCCCCCCC
HSQMWFLAQRFEQQREIADTPISLIQDRSIYEDYEVFAKGLLEQGIMSHRDFRTYRKLYQ
HHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIQSTTPPTLMVYLRGSVPTLLERIKKRARPSEMNISADYLSHLNNRYDEWLRRFELCP
HHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
VLTIETDDLDVVNRDDHRQQVIEIIGQAVGRRSNFQYRLPLNGDKA
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
>Mature Secondary Structure 
GHTFFGQHLYLSVAGNIGVGKSTLVETLAAAFGWQPYYEFVADHPYLDDFYADKHRWGF
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHCCCCCCCC
HSQMWFLAQRFEQQREIADTPISLIQDRSIYEDYEVFAKGLLEQGIMSHRDFRTYRKLYQ
HHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIQSTTPPTLMVYLRGSVPTLLERIKKRARPSEMNISADYLSHLNNRYDEWLRRFELCP
HHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
VLTIETDDLDVVNRDDHRQQVIEIIGQAVGRRSNFQYRLPLNGDKA
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]