Click here to switch to the map view.

The map label for this gene is 159901398

Identifier: 159901398

GI number: 159901398

Start: 6222962

End: 6224260

Strand: Reverse

Name: 159901398

Synonym: Haur_4887

Alternate gene names: NA

Gene position: 6224260-6222962 (Counterclockwise)

Preceding gene: 159901399

Following gene: 159901397

Centisome position: 98.07

GC content: 51.89

Gene sequence:

>1299_bases
ATGTTAAACGAAACCCATGATCCAGCTTTGCGCAGTTGGGTAGCCAGCGCCAACCTTGCTGGAGCCGATTTTCCGATTCA
AAATTTACCGTTTGGGGTGTTTCGTCGCCAAGCAAGCCACGAGCAATGGCGCATCGGCGTGGCTATCGGTGCTGAAATTC
TTGATTTAAGCAAAGCTGCTGAGTATTTGGGCGAGCTTGATCAAGCCAGTTTGGCAGCATGTCGGGCTGAAAACCTGAAT
CAATTAATGAGCTTAACGCCTGCGGTTTGGAGCACTATTCGCCTACAACTCAGCCGAATGTTGCGTGAAGGTTCAAGCTT
ACAGGCCGAATTAACTCCACTATTGCTAGCTCAAGCCGAGGCCGAAATGGCATTGCCTGCGGCAATTGGCGATTACACCG
ATTTCTATGCCTCGATTTTTCATGCGACCAATATTGGCTCGATGTTTCGCCCCGACAATCCACTTTTGCCCAATTATAAA
TATGTGCCGATTGGCTACCACGGGCGAGCTTCATCGATTCGAGTCAGTGGCGCAAGCATCAAACGCCCGCATGGTCAAAC
CAAAGCACCCGATGCTGAAGTGCCAACGTTTGGGCCATGTCGCTTGCTTGATTACGAATTAGAATTAGGGTTTTGGGTCG
GCCAAGGTAACGAGTTAGGTCAGCCAGTCAGCATTGAACAGGCCGAACATCATGTCTTTGGGGTTTGCTTGCTCAACGAT
TGGTCGGCACGCGACATTCAAGCCTGGGAATATCAGCCGCTTGGGCCATTTTTGGCTAAAAATTTCATCAGCAGCATCTC
GCCATGGGTCGTTACCCTCGAAGCCCTTGCACCTTATCGCTGCCCAGCCTTCGAGCGACCCGCCGATGATCCTGCGCCAC
TCGCCTACTTGGATAGCCCAGCCAATCGCAGTGCTGGTGGCCTTGATTTAACTCTTGAAGTTAGCCTGCAAACTGCCAGC
ATGCGCCAAGCGGGTCAAGCCGCCGAGGTGCTTAGCCTTGGTAATTTTAGCGATATGTATTGGACATTCGCCCAAATGCT
GACCCATCACACCAGCAACGGCTGTAATCTTGAACCTGGCGATTTATTGGGCAGTGGCACGATTTCAGGCCCAAGCAAAA
ACTCACGCGGCTGTTTGATGGAGCTAACTTGGCGTGGGCAAGAGCCAATTCAGCTCAGCAATGGCGAACAACGCCGCTTC
TTGCAAGCTGGCGATGAGGTGATTATTCGCGGGTGGTGTGGCGCAAGCGATGGCCTGAAAATTGGGCTGGGCGAGTGTCG
CGGCGTTATATTGGATTAA

Upstream 100 bases:

>100_bases
CGGCTTGATCGCCTTTGGTTCATGTTCATTCGAGGAGCCAATCAACGAATTTGCCAGCTTTATCGAGCAGCCAGCCTTGG
CCTATGGAGCAACCAATTAA

Downstream 100 bases:

>100_bases
GCAGCCTAAAGAACGAGGCTATGGGTTCGCTCATAGCCCTAGCACCATTCGTTGTCGAGTACAATAGCAGCCATGTACAA
TGATTATGCAACAATTTATC

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLNETHDPALRSWVASANLAGADFPIQNLPFGVFRRQASHEQWRIGVAIGAEILDLSKAAEYLGELDQASLAACRAENLN
QLMSLTPAVWSTIRLQLSRMLREGSSLQAELTPLLLAQAEAEMALPAAIGDYTDFYASIFHATNIGSMFRPDNPLLPNYK
YVPIGYHGRASSIRVSGASIKRPHGQTKAPDAEVPTFGPCRLLDYELELGFWVGQGNELGQPVSIEQAEHHVFGVCLLND
WSARDIQAWEYQPLGPFLAKNFISSISPWVVTLEALAPYRCPAFERPADDPAPLAYLDSPANRSAGGLDLTLEVSLQTAS
MRQAGQAAEVLSLGNFSDMYWTFAQMLTHHTSNGCNLEPGDLLGSGTISGPSKNSRGCLMELTWRGQEPIQLSNGEQRRF
LQAGDEVIIRGWCGASDGLKIGLGECRGVILD

Sequences:

>Translated_432_residues
MLNETHDPALRSWVASANLAGADFPIQNLPFGVFRRQASHEQWRIGVAIGAEILDLSKAAEYLGELDQASLAACRAENLN
QLMSLTPAVWSTIRLQLSRMLREGSSLQAELTPLLLAQAEAEMALPAAIGDYTDFYASIFHATNIGSMFRPDNPLLPNYK
YVPIGYHGRASSIRVSGASIKRPHGQTKAPDAEVPTFGPCRLLDYELELGFWVGQGNELGQPVSIEQAEHHVFGVCLLND
WSARDIQAWEYQPLGPFLAKNFISSISPWVVTLEALAPYRCPAFERPADDPAPLAYLDSPANRSAGGLDLTLEVSLQTAS
MRQAGQAAEVLSLGNFSDMYWTFAQMLTHHTSNGCNLEPGDLLGSGTISGPSKNSRGCLMELTWRGQEPIQLSNGEQRRF
LQAGDEVIIRGWCGASDGLKIGLGECRGVILD
>Mature_432_residues
MLNETHDPALRSWVASANLAGADFPIQNLPFGVFRRQASHEQWRIGVAIGAEILDLSKAAEYLGELDQASLAACRAENLN
QLMSLTPAVWSTIRLQLSRMLREGSSLQAELTPLLLAQAEAEMALPAAIGDYTDFYASIFHATNIGSMFRPDNPLLPNYK
YVPIGYHGRASSIRVSGASIKRPHGQTKAPDAEVPTFGPCRLLDYELELGFWVGQGNELGQPVSIEQAEHHVFGVCLLND
WSARDIQAWEYQPLGPFLAKNFISSISPWVVTLEALAPYRCPAFERPADDPAPLAYLDSPANRSAGGLDLTLEVSLQTAS
MRQAGQAAEVLSLGNFSDMYWTFAQMLTHHTSNGCNLEPGDLLGSGTISGPSKNSRGCLMELTWRGQEPIQLSNGEQRRF
LQAGDEVIIRGWCGASDGLKIGLGECRGVILD

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=418, Percent_Identity=49.2822966507177, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17568863, Length=420, Percent_Identity=51.1904761904762, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24657182, Length=417, Percent_Identity=48.9208633093525, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47084; Mature: 47084

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNETHDPALRSWVASANLAGADFPIQNLPFGVFRRQASHEQWRIGVAIGAEILDLSKAA
CCCCCCCHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
EYLGELDQASLAACRAENLNQLMSLTPAVWSTIRLQLSRMLREGSSLQAELTPLLLAQAE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AEMALPAAIGDYTDFYASIFHATNIGSMFRPDNPLLPNYKYVPIGYHGRASSIRVSGASI
HHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCC
KRPHGQTKAPDAEVPTFGPCRLLDYELELGFWVGQGNELGQPVSIEQAEHHVFGVCLLND
CCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
WSARDIQAWEYQPLGPFLAKNFISSISPWVVTLEALAPYRCPAFERPADDPAPLAYLDSP
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCCCEEEECCC
ANRSAGGLDLTLEVSLQTASMRQAGQAAEVLSLGNFSDMYWTFAQMLTHHTSNGCNLEPG
CCCCCCCEEEEEEEEEEHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCC
DLLGSGTISGPSKNSRGCLMELTWRGQEPIQLSNGEQRRFLQAGDEVIIRGWCGASDGLK
CCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCHHHHHHCCCEEEEEEECCCCCCCE
IGLGECRGVILD
EEHHHCCEEECC
>Mature Secondary Structure
MLNETHDPALRSWVASANLAGADFPIQNLPFGVFRRQASHEQWRIGVAIGAEILDLSKAA
CCCCCCCHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
EYLGELDQASLAACRAENLNQLMSLTPAVWSTIRLQLSRMLREGSSLQAELTPLLLAQAE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AEMALPAAIGDYTDFYASIFHATNIGSMFRPDNPLLPNYKYVPIGYHGRASSIRVSGASI
HHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCC
KRPHGQTKAPDAEVPTFGPCRLLDYELELGFWVGQGNELGQPVSIEQAEHHVFGVCLLND
CCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
WSARDIQAWEYQPLGPFLAKNFISSISPWVVTLEALAPYRCPAFERPADDPAPLAYLDSP
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCCCEEEECCC
ANRSAGGLDLTLEVSLQTASMRQAGQAAEVLSLGNFSDMYWTFAQMLTHHTSNGCNLEPG
CCCCCCCEEEEEEEEEEHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCC
DLLGSGTISGPSKNSRGCLMELTWRGQEPIQLSNGEQRRFLQAGDEVIIRGWCGASDGLK
CCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCHHHHHHCCCEEEEEEECCCCCCCE
IGLGECRGVILD
EEHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA